Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin

References

• Agyeman AA, Bergen PJ, Rao GG, et al. A systematic review and meta-analysis of treatment outcomes following antibiotic therapy among patients with carbapenem-resistant Klebsiella pneumoniae infections. Int J Antimicrob Agents. 2020;55:105833.
   PubMed Web of Science ®Google Scholar
• Andrey DO, Pereira Dantas P, Martins WBS, et al. An emerging clone, klebsiellapneumoniae carbapenemase 2-producing K. pneumoniae Sequence Type 16, associated With high mortality rates in a CC258-endemic setting. Clin Infect Dis. 2020;71:e141–e150.
   PubMed Web of Science ®Google Scholar
• Peirano G, Bradford PA, Kazmierczak KM, et al. Importance of clonal complex 258 and IncFK2-like plasmids among a global collection of Klebsiella pneumoniae with blaKPC. Antimicrob Agents Chemother. 2017;61:1–5.
   Google Scholar
• Zhang R, Liu L, Zhou H, et al. Nationwide surveillance of clinical carbapenem-resistant Enterobacteriaceae (CRE) strains in China. EBioMedicine. 2017;19:98–106.
   PubMed Web of Science ®Google Scholar
• Gu D, Dong N, Zheng Z, et al. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. Lancet Infect Dis. 2018;18:37–46.
   PubMed Web of Science ®Google Scholar
• Zhou K, Xiao T, David S, et al. Novel subclone of carbapenem-resistant Klebsiella pneumoniae Sequence Type 11 with enhanced virulence and transmissibility, China. Emerg Infect Dis. 2020;26:289–297.
   PubMed Web of Science ®Google Scholar
• Durante-Mangoni E, Andini R, Zampino R. Management of carbapenem-resistant Enterobacteriaceae infections. Clin Microbiol Infect. 2019;25:943–950.
   PubMed Web of Science ®Google Scholar
• Medeiros GS, Rigatto MH, Falci DR, et al. Combination therapy with polymyxin B for carbapenemase-producing Klebsiella pneumoniae bloodstream infection. Int J Antimicrob Agents. 2019;53:152–157.
   Web of Science ®Google Scholar
• Tsuji BT, Pogue JM, Zavascki AP, et al. International consensus guidelines for the optimal use of the polymyxins: endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDS). Pharmacotherapy. 2019;39:10–39.
   PubMed Web of Science ®Google Scholar
• Rafailidis PI, Falagas ME. Options for treating carbapenem-resistant enterobacteriaceae. Curr Opin Infect Dis. 2014;27:479–483.
   PubMed Web of Science ®Google Scholar
• Du X, He F, Shi Q, et al. The rapid emergence of tigecycline resistance in blaKPC-2 harboring Klebsiella pneumoniae, as mediated in vivo by mutation in tetA during tigecycline treatment. Front Microbiol. 2018;9:648.
   PubMed Web of Science ®Google Scholar
• Chiu S-K, Chan M-C, Huang L-Y, et al. Tigecycline resistance among carbapenem-resistant Klebsiella pneumoniae: Clinical characteristics and expression levels of efflux pump genes. PLoS One. 2017;12:e0175140.
   PubMed Web of Science ®Google Scholar
• Rojas LJ, Salim M, Cober E, et al. Colistin resistance in carbapenem-resistant Klebsiella pneumoniae: Laboratory detection and impact on mortality. Clin Infect Dis. 2017;64:711–718.
   PubMed Web of Science ®Google Scholar
• Pournaras S, Koumaki V, Spanakis N, et al. Current perspectives on tigecycline resistance in enterobacteriaceae: susceptibility testing issues and mechanisms of resistance. Int J Antimicrob Agents. 2016;48:11–18.
   PubMed Web of Science ®Google Scholar
• Chiu S, Huang L, Chen H, et al. Roles of ramR and tet(A) mutations in conferring tigecycline resistance in carbapenem-resistant Klebsiella pneumoniae clinical isolates. Antimicrob Agents Chemother. 2017;61:1–10.
   Web of Science ®Google Scholar
• He F, Shi Q, Fu Y, et al. Tigecycline resistance caused by rpsJ evolution in a 59-year-old male patient infected with KPC-producing Klebsiella pneumoniae during tigecycline treatment. Infect Genet Evol. 2018;66:188–191.
   Web of Science ®Google Scholar
• Poirel L, Jayol A, Nordmann P. Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clin Microbiol Rev. 2017;30:557–596.
   PubMed Web of Science ®Google Scholar
• Quan J, Li X, Chen Y, et al. Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study. Lancet Infect Dis. 2017;17:400–410.
   PubMed Web of Science ®Google Scholar
• Zaidah AR, Mohammad NI, Suraiya S, et al. High burden of carbapenem-resistant enterobacteriaceae (CRE) fecal carriage at a teaching hospital: cost-effectiveness of screening in low-resource setting. Antimicrob Resist Infect Control. 2017;6:1–6.
   Web of Science ®Google Scholar
• Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 30th ed. CLSI supplement M100. Wayne, PA: Clin. Lab. Stand. Inst. 2020.
   Google Scholar
• Wu K-M, Li L-H, Yan J-J, et al. Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis. J Bacteriol. 2009;191:4492–4501.
   PubMed Web of Science ®Google Scholar
• Zhang P, Shi Q, Hu H, et al. Emergence of ceftazidime/avibactam resistance in carbapenem-resistant Klebsiella pneumoniae in China. Clin Microbiol Infect. 2020;26:124.e1–124.e4.
   Web of Science ®Google Scholar
• Poirel L, Walsh TR, Cuvillier V, et al. Multiplex PCR for detection of acquired carbapenemase genes. Diagn Microbiol Infect Dis. 2011;70:119–123.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang L, Li R, et al. Presence and characterization of Klebsiella pneumoniae from the intestinal tract of diarrhoea patients. Lett Appl Microbiol. 2018;66:514–522.
   Web of Science ®Google Scholar
• Wang Q, Zhang P, Zhao D, et al. Emergence of tigecycline resistance in Escherichia coli co-producing MCR-1 and NDM-5 during tigecycline salvage treatment. Infect Drug Resist. 2018;11:2241–2248.
   PubMed Web of Science ®Google Scholar
• Ji S, Jiang S, Wei X, et al. In-host evolution of daptomycin resistance and heteroresistance in methicillin-resistant staphylococcus aureus strains from three endocarditis patients. J Infect Dis. 2020;221:S243–S252.
   PubMed Web of Science ®Google Scholar
• Wick RR, Judd LM, Gorrie CL, et al. Unicycler: resolving bacterial genome assemblies from short and long sequencing reads. PLoS Comput Biol. 2017;13:1–22.
   Web of Science ®Google Scholar
• Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinformatics. 2014;30:2068–2069.
   PubMed Web of Science ®Google Scholar
• Fontana C, Angeletti S, Mirandola W, et al. Whole genome sequencing of carbapenem-resistant Klebsiella pneumoniae: evolutionary analysis for outbreak investigation. Future Microbiol. 2020;15:203–212.
   Web of Science ®Google Scholar
• Grant JR, Stothard P. The CGView server: a comparative genomics tool for circular genomes. Nucleic Acids Res. 2008;36:181–184.
   PubMed Web of Science ®Google Scholar
• Cheng YH, Huang TW, Juan CH, et al. Tigecycline-non-susceptible hypervirulent Klebsiella pneumoniae strains in Taiwan. J Antimicrob Chemother. 2020;75:309–317.
   Web of Science ®Google Scholar
• Li R, Peng K, Li Y, et al. Exploring tet(X)-bearing tigecycline-resistant bacteria of swine farming environments. Sci Total Environ. 2020;733:139306.
   PubMed Web of Science ®Google Scholar
• Zhan L, Wang S, Guo Y, et al. Outbreak by hypermucoviscous Klebsiella pneumoniae ST11 isolates with carbapenem resistance in a tertiary hospital in China. Front Cell Infect Microbiol. 2017;7:182.
   PubMed Web of Science ®Google Scholar
• Dong N, Yang X, Zhang R, et al. Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains. Emerg Microbes Infect. 2018;7:146.
   PubMed Web of Science ®Google Scholar
• Kang H, Zheng W, Kong Z, et al. Disease burden and molecular epidemiology of carbapenem-resistant Klebsiella pneumonia infection in a tertiary hospital in China. Ann Transl Med. 2020;8:605.
   Web of Science ®Google Scholar
• Zheng B, Dai Y, Liu Y, et al. Molecular epidemiology and risk factors of carbapenem-resistant Klebsiella pneumoniae infections in Eastern China. Front Microbiol. 2017;8:1–11.
   PubMed Web of Science ®Google Scholar
• Lai Y-C, Lu M-C, Hsueh P-R. Hypervirulence and carbapenem resistance: two distinct evolutionary directions that led high-risk Klebsiella pneumoniae clones to epidemic success. Expert Rev Mol Diagn. 2019;19:825–837.
   PubMed Web of Science ®Google Scholar
• Clegg S, Murphy CN. Epidemiology and virulence of Klebsiella pneumoniae. Microbiol Spectr. 2016;4; DOI:https://doi.org/10.1128/microbiolspec.UTI-0005-2012.
   Google Scholar
• Russo TA, Marr CM. Hypervirulent Klebsiella pneumoniae. Clin Microbiol Rev. 2019;32:1–42.
   PubMed Web of Science ®Google Scholar
• Russo TA, Olson R, Macdonald U, et al. Aerobactin mediates virulence and accounts for increased siderophore production under iron-limiting conditions by hypervirulent (hypermucoviscous) Klebsiella pneumoniae. Infect Immun. 2014;82:2356–2367.
   PubMed Web of Science ®Google Scholar
• Shu L, Dong N, Lu J, et al. Emergence of OXA-232 carbapenemase-producing Klebsiella pneumoniae that carries a pLVPK-like virulence plasmid among elderly patients in China. Antimicrob Agents Chemother. 2019;63:1–6.
   Web of Science ®Google Scholar
• Roy S, Datta S, Viswanathan R, et al. Tigecycline susceptibility in Klebsiella pneumoniae and Escherichia coli causing neonatal septicaemia (2007-10) and role of an efflux pump in tigecycline non-susceptibility. J Antimicrob Chemother. 2013;68:1036–1042.
   Web of Science ®Google Scholar
• Sheng Z-K, Hu F, Wang W, et al. Mechanisms of tigecycline resistance among Klebsiella pneumoniae clinical isolates. Antimicrob Agents Chemother. 2014;58:6982–6985.
   Web of Science ®Google Scholar
• Fang L, Chen Q, Shi K, et al. Step-wise increase in tigecycline resistance in Klebsiella pneumoniae associated with mutations in ramR, lon and rpsJ. PLoS One. 2016;11:e0165019.
   Web of Science ®Google Scholar
• Dong N, Lin D, Zhang R, et al. Carriage of blaKPC-2 by a virulence plasmid in hypervirulent Klebsiella pneumoniae. J Antimicrob Chemother. 2018;73:3317–3321.
   PubMed Web of Science ®Google Scholar
• Porse A, Schønning K, Munck C, et al. Survival and evolution of a large multidrug resistance plasmid in new clinical bacterial hosts. Mol Biol Evol. 2016;33:2860–2873.
   Web of Science ®Google Scholar
• Ye M, Ding B, Qian H, et al. In vivo development of tigecycline resistance in Klebsiella pneumoniae owing to deletion of the ramR ribosomal binding site. Int J Antimicrob Agents. 2017;50:523–528.
   Web of Science ®Google Scholar
• Qin X, Wu S, Hao M, et al. The colonization of carbapenem-resistant Klebsiella pneumoniae: epidemiology, resistance mechanisms, and risk factors in patients admitted to intensive care units in China. J Infect Dis. 2020;221:S206–S214.
   PubMed Web of Science ®Google Scholar
• Zhen X, Stålsby Lundborg C, Sun X, et al. Clinical and economic burden of carbapenem-resistant infection or colonization caused by Klebsiella pneumoniae, pseudomonas aeruginosa, acinetobacter baumannii: a multicenter study in China. Antibiot (Basel, Switzerland). 2020;9:1–13.
   Web of Science ®Google Scholar
• Zhang R, Dong N, Huang Y, et al. Evolution of tigecycline- and colistin-resistant CRKP (carbapenem-resistant Klebsiella pneumoniae) in vivo and its persistence in the GI tract. Emerg Microbes Infect. 2018;7:127.
   Web of Science ®Google Scholar