References
- Alexander DJ. An overview of the epidemiology of avian influenza. Vaccine. 2007 Jul 26;25(30):5637–5644. doi:https://doi.org/10.1016/j.vaccine.2006.10.051. PubMed PMID: 17126960.
- Verhagen JH, Fouchier RAM, Lewis N. Highly Pathogenic Avian Influenza Viruses at the wild-domestic bird Interface in Europe: future directions for Research and surveillance. Viruses-Basel. 2021 Feb;13(2):212, doi: https://doi.org/10.1016/ARTN212.3390/v13020212. PubMed PMID: WOS:000623322700001; English.
- Philippon DAM, Wu P, Cowling BJ, et al. Avian influenza human infections at the human-Animal interface. J Infect Dis. 2020 Jul 23;222(4):528–537. doi: https://doi.org/10.1093/infdis/jiaa105. PubMed PMID: 32157291.
- Reperant LA, Rimmelzwaan GF, Kuiken T. Avian influenza viruses in mammals. Rev Sci Tech. 2009 Apr;28(1):137–159. doi:https://doi.org/10.20506/rst.28.1.1876. PubMed PMID: 19618623; eng.
- Fouchier RA, Munster V, Wallensten A, et al. Characterization of a novel influenza A virus hemagglutinin subtype (H16) obtained from black-headed gulls. J Virol. 2005 Mar;79(5):2814–2822. doi:https://doi.org/10.1128/JVI.79.5.2814-2822.2005. PubMed PMID: 15709000; PubMed Central PMCID: PMCPMC548452.
- Lloren KKS, Lee T, Kwon JJ, et al. Molecular markers for Interspecies Transmission of avian influenza viruses in mammalian hosts. Int J Mol Sci. 2017 Dec 13;18(12):2706, doi:https://doi.org/10.3390/ijms18122706. PubMed PMID: 29236050; PubMed Central PMCID: PMCPMC5751307.
- Herfst S, Imai M, Kawaoka Y, et al. Avian influenza virus transmission to mammals. Curr Top Microbiol Immunol. 2014;385:137–155. PubMed PMID: 25048542; eng.
- Zanin M, Wong SS, Barman S, et al. Molecular basis of mammalian transmissibility of avian H1N1 influenza viruses and their pandemic potential. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11217–11222. doi:https://doi.org/10.1073/pnas.1713974114. PubMed PMID: 28874549; PubMed Central PMCID: PMCPMC5651783.
- Li Z, Jiang Y, Jiao P, et al. The NS1 gene contributes to the virulence of H5N1 avian influenza viruses. J Virol. 2006 Nov;80(22):11115–11123. doi:https://doi.org/10.1128/JVI.00993-06. PubMed PMID: 16971424; PubMed Central PMCID: PMCPMC1642184.
- Ayllon J, Domingues P, Rajsbaum R, et al. A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence. J Virol. 2014 Oct;88(20):12146–12151. doi:https://doi.org/10.1128/JVI.01567-14. PubMed PMID: 25078692; PubMed Central PMCID: PMCPMC4178744.
- Long JX, Peng DX, Liu YL, et al. Virulence of H5N1 avian influenza virus enhanced by a 15-nucleotide deletion in the viral nonstructural gene. Virus Genes. 2008 Jun;36(3):471–478. doi:https://doi.org/10.1007/s11262-007-0187-8. PubMed PMID: 18317917.
- Zhu Q, Yang H, Chen W, et al. A naturally occurring deletion in its NS gene contributes to the attenuation of an H5N1 swine influenza virus in chickens. J Virol. 2008 Jan;82(1):220–228. doi:https://doi.org/10.1128/JVI.00978-07. PubMed PMID: 17942562; PubMed Central PMCID: PMCPMC2224367.
- Wang J, Zeng Y, Xu S, et al. A naturally occurring deletion in the effector domain of H5N1 swine influenza virus nonstructural protein 1 regulates viral fitness and host Innate immunity. J Virol. 2018 Jun 1;92(11). PubMed PMID: 29563291; PubMed Central PMCID: PMCPMC5952131.
- Hutchinson EC, Charles PD, Hester SS, et al. Conserved and host-specific features of influenza virion architecture. Nat Commun. 2014 Sep 16;5:4816, doi:https://doi.org/10.1038/ncomms5816. PubMed PMID: 25226414; PubMed Central PMCID: PMCPMC4167602.
- Hale BG, Randall RE, Ortin J, et al. The multifunctional NS1 protein of influenza A viruses [Research support, Non-U.S. gov’t review]. J Gen Virol. 2008 Oct;89(Pt 10):2359–2376. doi:https://doi.org/10.1099/vir.0.2008/004606-0. PubMed PMID: 18796704; eng.
- Marc D. Influenza virus non-structural protein NS1: interferon antagonism and beyond. J Gen Virol. 2014 Dec;95(Pt 12):2594–2611. doi:https://doi.org/10.1099/vir.0.069542-0. PubMed PMID: 25182164.
- Moltedo B, Lopez CB, Pazos M, et al. Cutting edge: stealth influenza virus replication precedes the initiation of adaptive immunity. J Immunol. 2009 Sep 15;183(6):3569–3573. doi:https://doi.org/10.4049/jimmunol.0900091. PubMed PMID: 19717515; eng.
- Dundon WG, Milani A, Cattoli G, et al. Progressive truncation of the Non-structural 1 gene of H7N1 avian influenza viruses following extensive circulation in poultry. Virus Res. 2006 Aug;119(2):171–176. doi:https://doi.org/10.1016/j.virusres.2006.01.005. PubMed PMID: 16464514.
- Suarez DL, Perdue ML. Multiple alignment comparison of the non-structural genes of influenza A viruses. Virus Res. 1998 Mar;54(1):59–69. doi:https://doi.org/10.1016/s0168-1702(98)00011-2. PubMed PMID: 9660072.
- Abdelwhab el SM, Veits J, Breithaupt A, et al. Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens. Virulence. 2016 Jul 3;7(5):546–557. doi:https://doi.org/10.1080/21505594.2016.1159367. PubMed PMID: 26981790; PubMed Central PMCID: PMCPMC5026787.
- Hale BG, Steel J, Manicassamy B, et al. Mutations in the NS1 C-terminal tail do not enhance replication or virulence of the 2009 pandemic H1N1 influenza A virus. J Gen Virol. 2010 Jul;91(Pt 7):1737–1742. doi:https://doi.org/10.1099/vir.0.020925-0. PubMed PMID: 20237225; PubMed Central PMCID: PMCPMC3052525. eng.
- Blaurock C, Breithaupt A, Scheibner D, et al. Preferential selection and contribution of non-structural protein 1 (NS1) to the efficient transmission of the panzootic avian influenza H5N8 2.3.4.4 clades A and B viruses in chickens and ducks. J Virol. 2021 Jun 23: JVI0044521), doi: https://doi.org/10.1128/JVI.00445-21. PubMed PMID: 34160261.
- Soubies SM, Volmer C, Croville G, et al. Species-specific contribution of the four C-terminal amino acids of influenza A virus NS1 protein to virulence. J Virol. 2010 Jul;84(13):6733–6747. doi:https://doi.org/10.1128/JVI.02427-09. PubMed PMID: 20410267; PubMed Central PMCID: PMCPMC2903243.
- Zielecki F, Semmler I, Kalthoff D, et al. Virulence determinants of avian H5N1 influenza A virus in mammalian and avian hosts: role of the C-terminal ESEV motif in the viral NS1 protein. J Virol. 2010 Oct;84(20):10708–10718. doi:https://doi.org/10.1128/JVI.00610-10. PubMed PMID: 20686040; PubMed Central PMCID: PMCPMC2950580.
- Kong W, Liu L, Wang Y, et al. C-terminal elongation of NS1 of H9N2 influenza virus induces a high level of inflammatory cytokines and increases transmission. J Gen Virol. 2015 Feb;96(Pt 2):259–268. doi: https://doi.org/10.1099/vir.0.071001-0. PubMed PMID: 25326314; eng.
- Guan Y, Smith GJ. The emergence and diversification of panzootic H5N1 influenza viruses. Virus Res. 2013 Dec 5;178(1):35–43. doi:https://doi.org/10.1016/j.virusres.2013.05.012. PubMed PMID: 23735533; PubMed Central PMCID: PMCPMC4017639.
- Ip HS, Torchetti MK, Crespo R, et al. Novel Eurasian highly pathogenic avian influenza A H5 viruses in wild birds, Washington, USA, 2014. Emerg Infect Dis. 2015 May;21(5):886-90. doi: https://doi.org/10.3201/eid2105.142020. PubMed PMID: 25898265; PubMed Central PMCID: PMCPMC4412248.
- Pasick J, Berhane Y, Joseph T, et al. Reassortant highly pathogenic influenza A H5N2 virus containing gene segments related to Eurasian H5N8 in British Columbia, Canada, 2014. Sci Rep. 2015 Mar 25;5:9484. doi: https://doi.org/10.1038/srep09484. PubMed PMID: 25804829; PubMed Central PMCID: PMCPMC4372658.
- WHO. Human infection with avian influenza A (H5N8) – the Russian Federation. Available online at: https://www.who.int/csr/don/26-feb-2021-influenza-a-russian-federation/en/ (Accessed 26-03-2021). 2021.
- Shin DL, Siebert U, Lakemeyer J, et al. Highly Pathogenic Avian Influenza a(H5N8) virus in gray seals, baltic Sea. Emerg Infect Dis. 2019 Dec;25(12):2295–2298. doi:https://doi.org/10.3201/eid2512.181472. PubMed PMID: 31742519; PubMed Central PMCID: PMCPMC6874272. eng.
- Yamaji R, Saad MD, Davis CT, et al. Pandemic potential of highly pathogenic avian influenza clade 2.3.4.4 A(H5) viruses. Rev Med Virol. 2020 May;30(3):e2099, doi: https://doi.org/10.1002/rmv.2099. PubMed PMID: 32135031; eng.
- Katoh K, Standley DM. MAFFT multiple sequence alignment software version 7: improvements in performance and usability. Mol Biol Evol. 2013 Apr;30(4):772–780. doi:https://doi.org/10.1093/molbev/mst010. PubMed PMID: 23329690; PubMed Central PMCID: PMCPMC3603318.
- Mostafa A, Blaurock C, Scheibner D, et al. Genetic incompatibilities and reduced transmission in chickens may limit the evolution of reassortants between H9N2 and panzootic H5N8 clade 2.3.4.4 avian influenza virus showing high virulence for mammals. Virus Evol. 2020 Jul;6(2):veaa077, doi: https://doi.org/10.1093/ve/veaa077. PubMed PMID: 33343923; PubMed Central PMCID: PMCPMC7733613.
- Hennion RM, Hill G. The preparation of chicken kidney cell cultures for virus propagation. Methods Mol Biol. 2015;1282:57–62. doi:https://doi.org/10.1007/978-1-4939-2438-7_6. PubMed PMID: 25720471; PubMed Central PMCID: PMCPMC7122669.
- Blaurock C, Scheibner D, Landmann M, et al. Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys. Sci Rep. 2020 Dec 4;10(1):21226, doi:https://doi.org/10.1038/s41598-020-78210-8. PubMed PMID: 33277593; PubMed Central PMCID: PMCPMC7718272.
- Petersen H, Mostafa A, Tantawy MA, et al. NS segment of a 1918 influenza A virus-descendent enhances replication of H1N1pdm09 and virus-induced cellular immune response in mammalian and avian systems. Front Microbiol. 2018;9:526, doi:https://doi.org/10.3389/fmicb.2018.00526. PubMed PMID: 29623073; PubMed Central PMCID: PMCPMC5874506.
- Peters MA, Browning GF, Washington EA, et al. Embryonic age influences the capacity for cytokine induction in chicken thymocytes. Immunology. 2003;110(3):358–367. doi:https://doi.org/10.1046/j.1365-2567.2003.01744.x. PubMed PMID: 14632664; eng.
- Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 2001 Dec;25(4):402–408. doi:https://doi.org/10.1006/meth.2001.1262. PubMed PMID: 11846609.
- Hoffmann B, Hoffmann D, Henritzi D, et al. Riems influenza a typing array (RITA): An RT-qPCR-based low density array for subtyping avian and mammalian influenza a viruses. Sci Rep. 2016 Jun 3;6:27211, doi:https://doi.org/10.1038/srep27211. PubMed PMID: 27256976; PubMed Central PMCID: PMCPMC4891686.
- Tu J, Guo J, Zhang A, et al. Effects of the C-terminal truncation in NS1 protein of the 2009 pandemic H1N1 influenza virus on host gene expression. PloS one. 2011;6(10):e26175, doi:https://doi.org/10.1371/journal.pone.0026175. PubMed PMID: 22022552; PubMed Central PMCID: PMCPMC3192165. eng.
- Jackson D, Hossain MJ, Hickman D, et al. A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4381–4386. doi:https://doi.org/10.1073/pnas.0800482105. PubMed PMID: 18334632; PubMed Central PMCID: PMCPMC2393797.
- Lam WY, Tang JW, Yeung AC, et al. Avian influenza virus A/HK/483/97(H5N1) NS1 protein induces apoptosis in human airway epithelial cells. J Virol. 2008 Mar;82(6):2741–2751. doi:https://doi.org/10.1128/JVI.01712-07. PubMed PMID: 18199656; PubMed Central PMCID: PMCPMC2258969.
- Liu H, Golebiewski L, Dow EC, et al. The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting scribble. J Virol. 2010 Nov;84(21):11164–11174. doi:https://doi.org/10.1128/JVI.01278-10. PubMed PMID: 20702615; PubMed Central PMCID: PMCPMC2953166.
- Jackson D, Killip MJ, Galloway CS, et al. Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3 K). Virology. 2010 Jan 5;396(1):94–105. doi:https://doi.org/10.1016/j.virol.2009.10.004. PubMed PMID: 19880155.
- Nogales A, Martinez-Sobrido L, Topham DJ, et al. Modulation of Innate immune responses by the influenza A NS1 and PA-X proteins. Viruses. 2018 Dec 12;10(12):708, doi:https://doi.org/10.3390/v10120708. PubMed PMID: 30545063; PubMed Central PMCID: PMCPMC6315843. eng.
- Liedmann S, Hrincius ER, Anhlan D, et al. New virulence determinants contribute to the enhanced immune response and reduced virulence of an influenza A virus A/PR8/34 variant. J Infect Dis. 2014 Feb 15;209(4):532–541. doi:https://doi.org/10.1093/infdis/jit463. PubMed PMID: 23983213; eng.
- Ozawa M, Basnet S, Burley LM, et al. Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses. J Virol. 2011 May;85(9):4596–4601. doi: https://doi.org/10.1128/JVI.00029-11. PubMed PMID: 21325408; PubMed Central PMCID: PMCPMC3126221. eng.
- Reperant LA, Kuiken T, Osterhaus AD. Adaptive pathways of zoonotic influenza viruses: from exposure to establishment in humans. Vaccine. 2012 Jun 22;30(30):4419–4434. doi:https://doi.org/10.1016/j.vaccine.2012.04.049. PubMed PMID: 22537992.
- Zhirnov OP, Konakova TE, Wolff T, et al. NS1 protein of influenza A virus down-regulates apoptosis. J Virol. 2002 Feb;76(4):1617–1625. doi:https://doi.org/10.1128/jvi.76.4.1617-1625.2002. PubMed PMID: 11799156; PubMed Central PMCID: PMCPMC135891.
- Ehrhardt C, Wolff T, Pleschka S, et al. Influenza A virus NS1 protein activates the PI3 K/Akt pathway to mediate antiapoptotic signaling responses. J Virol. 2007 Apr;81(7):3058–3067. doi:https://doi.org/10.1128/jvi.02082-06. PubMed PMID: 17229704; PubMed Central PMCID: PMCPMC1866065. eng.
- Hale BG, Steel J, Medina RA, et al. Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein. J Virol. 2010 Jul;84(14):6909–6922. doi:https://doi.org/10.1128/JVI.00081-10. PubMed PMID: 20444891; PubMed Central PMCID: PMCPMC2898253. eng.
- Clark AM, Nogales A, Martinez-Sobrido L, et al. Functional Evolution of influenza virus NS1 protein in currently circulating human 2009 pandemic H1N1 viruses. J Virol. 2017 Sep 1;91(17). doi:https://doi.org/10.1128/JVI.00721-17. PubMed PMID: 28637754; PubMed Central PMCID: PMCPMC5553169. eng.
- Nogales A, Martinez-Sobrido L, Chiem K, et al. Functional Evolution of the 2009 pandemic H1N1 influenza virus NS1 and PA in humans. J Virol. 2018 Oct 1;92(19). doi:https://doi.org/10.1128/JVI.01206-18. PubMed PMID: 30021892; PubMed Central PMCID: PMCPMC6146824. eng.
- Vigeveno RM, Poen MJ, Parker E, et al. Outbreak severity of highly Pathogenic Avian Influenza A(H5N8) viruses Is inversely correlated to polymerase complex activity and interferon induction. J Virol. 2020 May 18;94(11):e00375–20. doi:https://doi.org/10.1128/JVI.00375-20. PubMed PMID: 32238581; PubMed Central PMCID: PMCPMC7269427.
- Penski N, Härtle S, Rubbenstroth D, et al. Highly Pathogenic Avian Influenza Viruses do Not inhibit interferon Synthesis in infected chickens but Can override the interferon-induced antiviral state. J Virol. 2011;85(15):7730–7741. doi: https://doi.org/10.1128/JVI.00063-11.
- Mi Z, Ma Y, Tong Y. Avian influenza virus H5N1 induces rapid interferon-beta production but shows more potent inhibition to retinoic acid-inducible gene I expression than H1N1 in vitro. Virol J. 2012 Aug 3;9:145, doi:https://doi.org/10.1186/1743-422x-9-145. PubMed PMID: 22862800; PubMed Central PMCID: PMCPMC3464129. eng.
- Wurzer WJ, Planz O, Ehrhardt C, et al. Caspase 3 activation is essential for efficient influenza virus propagation. EMBO J. 2003;22(11):2717–2728. doi:https://doi.org/10.1093/emboj/cdg279. PubMed PMID: 12773387; eng.
- Grund C, Hoffmann D, Ulrich R, et al. A novel European H5N8 influenza A virus has increased virulence in ducks but low zoonotic potential. Emerg Microbes Infect. 2018 Jul 19;7(1):132, doi:https://doi.org/10.1038/s41426-018-0130-1. PubMed PMID: 30026505; PubMed Central PMCID: PMCPMC6053424.
- Kim YI, Pascua PN, Kwon HI, et al. Pathobiological features of a novel, highly pathogenic avian influenza A(H5N8) virus. Emerg Microbes Infect. 2014 Oct;3(10):e75, PubMed PMID: 26038499; PubMed Central PMCID: PMCPMC4217095. eng.