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Research Article

The emerging tick-borne pathogen Neoehrlichia mikurensis: first French case series and vector epidemiology

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Pages 1731-1738 | Received 20 May 2021, Accepted 23 Aug 2021, Published online: 02 Sep 2021

References

  • Dantas-Torres F, Chomel BB, Otranto D. Ticks and tick-borne diseases: a one health perspective. Trends Parasitol. 2012;28:437–446.
  • Moutailler S, Valiente Moro C, Vaumourin E, et al. Co-infection of ticks: the rule rather than the exception. PLOS Negl Trop Dis. 2016;10(3):e0004539.
  • Nebbak A, Dahmana H, Almeras L, et al. Co-infection of bacteria and protozoan parasites in Ixodes ricinus nymphs collected in the Alsace region. France Ticks Tick-Borne Dis. 2019;10(6):101241. doi:https://doi.org/10.1016/j.ttbdis.2019.06.001
  • Stanek G, Reiter M. The expanding Lyme Borrelia complex—clinical significance of genomic species? Clin Microbiol Infect. 2011;17:487–493.
  • Kawahara M, Rikihisa Y, Isogai E, et al. Ultrastructure and phylogenetic analysis of “Candidatus Neoehrlichia mikurensis” in the family Anaplasmataceae, isolated from wild rats and found in Ixodes ovatus ticks. Int J Syst Evol Microbiol. 2004;54:1837–1843.
  • Raoult D. Uncultured Candidatus neoehrlichia mikurensis. Clin Infect Dis Off Publ Infect Dis Soc Am. 2014;59(7):59–1042.
  • Wennerås C. Infections with the tick-borne bacterium Candidatus Neoehrlichia mikurensis. Clin Microbiol Infect. 2015;21:621–630.
  • Li H, Jiang J-F, Liu W, et al. Human infection with Candidatus Neoehrlichia mikurensis, China. Emerg Infect Dis. 2012;18:1636–1639.
  • Portillo A, Santibáñez P, Palomar AM, et al. ‘Candidatus Neoehrlichia mikurensis’ in Europe. New Microbes New Infect. 2018;22:30–36.
  • Grankvist A, Andersson P-O, Mattsson M, et al. Infections with the tick-borne bacterium “Candidatus Neoehrlichia mikurensis” mimic noninfectious conditions in patients With B cell malignancies or autoimmune diseases. Clin Infect Dis. 2014;58:1716–1722.
  • Höper L, Skoog E, Stenson M, et al. Vasculitis due to Candidatus Neoehrlichia mikurensis: a cohort study of 40 Swedish patients. Clin Infect Dis. 2020;Aug 20:ciaa1217. doi:https://doi.org/10.1093/cid/ciaa1217
  • Wass L, Grankvist A, Bell-Sakyi L, et al. Cultivation of the causative agent of human neoehrlichiosis from clinical isolates identifies vascular endothelium as a target of infection. Emerg Microbes Infect. 2019;8:413–425.
  • Welc-Falęciak R, Siński E, Kowalec M, et al. Asymptomatic “Candidatus Neoehrlichia mikurensis” Infections in immunocompetent humans. J Clin Microbiol. 2014;52:3072–3074.
  • Jahfari S, Hofhuis A, Fonville M, et al. Molecular detection of tick-borne pathogens in humans with tick bites and erythema Migrans, in the Netherlands. PLoS Negl Trop Dis. 2016;10:e0005042.
  • Vandenesch A, Turbelin C, Couturier E, et al. Incidence and hospitalisation rates of Lyme borreliosis, France, 2004 to 2012. Eurosurveillance. 2014;Aug 28;19(34):20883. doi:https://doi.org/10.2807/1560-7917.es2014.19.34.20883.
  • Ferquel E, Garnier M, Marie J, et al. Prevalence of Borrelia burgdorferi sensu lato and Anaplasmataceae members in Ixodes ricinus ticks in Alsace, a focus of Lyme Borreliosis endemicity in France. Appl Environ Microbiol. 2006;72:3074–3078.
  • Strle F, Stanek G. Clinical manifestations and diagnosis of Lyme borreliosis. Curr Probl Dermatol. 2009;37:51–110.
  • Goldstein V, Boulanger N, Schwartz D, et al. Factors responsible for Ixodes ricinus nymph abundance: Are soil features indicators of tick abundance in a French region where Lyme borreliosis is endemic? Ticks Tick-Borne Dis. 2018;9:938–944.
  • Boyer PH, Koetsveld J, Zilliox L, et al. Assessment of Borrelia miyamotoi in febrile patients and ticks in alsace, an endemic area for Lyme borreliosis in France. Parasit Vectors. 2020;Apr 17;13(1):199. doi:https://doi.org/10.1186/s13071-020-04071-9.
  • Guy EC, Stanek G. Detection of Borrelia burgdorferi in patients with Lyme disease by the polymerase chain reaction. J Clin Pathol. 1991;44:610–611.
  • Rijpkema S, Golubić D, Molkenboer M, et al. Identification of four genomic groups of Borrelia burgdorferi sensu lato in Ixodes ricinus ticks collected in a Lyme borreliosis endemic region of northern Croatia. Exp Appl Acarol. 1996;20:23–30.
  • Jahfari S, Fonville M, Hengeveld P, et al. Prevalence of Neoehrlichia mikurensis in ticks and rodents from north-west Europe. Parasit Vectors. 2012;Apr 19;5:74. doi:https://doi.org/10.1186/1756-3305-5-74.
  • Eisen L, Lane RS. Vectors of Borrelia burgdorferi sensu lato. Lyme Borreliosis Biol Epidemiol Control. CABI. Oxon, UK ; New York: CABI Pub; 2002. p. 91–116.
  • Richter D, Matuschka F-R. Candidatus Neoehrlichia mikurensis,” Anaplasma phagocytophilum, and Lyme disease spirochetes in questing European vector ticks and in feeding ticks removed from people. J Clin Microbiol. 2012;50:943–947.
  • Michelet L, Delannoy S, Devillers E, et al. High-throughput screening of tick-borne pathogens in Europe. Front Cell Infect Microbiol [Internet]. 2014 [cited 2020 Jul 30];4. Available from: https://www.frontiersin.org/articles/https://doi.org/10.3389/fcimb.2014.00103/full.
  • Boulanger N, Zilliox L, Goldstein V, et al. Surveillance du vecteur de la borréliose de lyme, Ixodes ricinus, en Alsace de 2013 à 2016. Bull Epidémiologique Hebd. 2018;19–20:400–405.
  • Burri C, Schumann O, Schumann C, et al. Are Apodemus spp. mice and Myodes glareolus reservoirs for Borrelia miyamotoi, Candidatus Neoehrlichia mikurensis, Rickettsia helvetica, R. monacensis and Anaplasma phagocytophilum? Ticks Tick-Borne Dis. 2014;5:245–251.
  • Kurtenbach K, Hanincová K, Tsao JI, et al. Fundamental processes in the evolutionary ecology of Lyme borreliosis. Nat Rev Microbiol. 2006;4:660–669.
  • Ostfeld RS, Canham CD, Oggenfuss K, et al. Climate, deer, rodents, and acorns as determinants of variation in lyme-disease risk. PLoS Biol. 2006;4:e145.
  • Okeyo M, Hepner S, Rollins RE, et al. Longitudinal study of prevalence and spatio-temporal distribution of Borrelia burgdorferi sensu lato in ticks from three defined habitats in Latvia, 1999-2010. Environ Microbiol. 2020;Dec;22(12):5033–5047.
  • Bestehorn M, Weigold S, Kern WV, et al. Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper rhine region in France and Germany. PLOS ONE. 2018;13:e0204790.
  • Velay A, Solis M, Kack-Kack W, et al. A new hot spot for tick-borne encephalitis (TBE): a marked increase of TBE cases in France in 2016. Ticks Tick-Borne Dis. 2018;9:120–125.
  • Grankvist A, Sandelin LL, Andersson J, et al. Infections with Candidatus Neoehrlichia mikurensis and cytokine responses in 2 persons bitten by ticks, Sweden. Emerg Infect Dis. 2015;21:1462–1465.
  • Quarsten H, Salte T, Lorentzen ÅR, et al. Tick-Borne pathogens detected in the blood of immunosuppressed Norwegian patients living in a tick-endemic area. Clin Infect Dis Off Publ Infect Dis Soc Am. 2020;Jul 14;ciaa971. doi:https://doi.org/10.1093/cid/ciaa971
  • von Loewenich FD, Geissdörfer W, Disqué C, et al. Detection of “Candidatus Neoehrlichia mikurensis” in two patients with severe febrile illnesses: evidence for a European sequence variant. J Clin Microbiol. 2010;48:2630–2635.
  • Maurer FP, Keller PM, Beuret C, et al. Close geographic association of human neoehrlichiosis and tick populations carrying “Candidatus Neoehrlichia mikurensis” in eastern Switzerland. J Clin Microbiol. 2013;51:169–176.
  • Pekova S, Vydra J, Kabickova H, et al. Candidatus Neoehrlichia mikurensis infection identified in 2 hematooncologic patients: benefit of molecular techniques for rare pathogen detection. Diagn Microbiol Infect Dis. 2011;69:266–270.
  • Markowicz M, Schötta A-M, Höss D, et al. Infections with Tickborne pathogens after tick bite, Austria, 2015-2018. Emerg Infect Dis. 2021;Apr;27(4):1048–1056. doi:https://doi.org/10.3201/eid2704.203366
  • Hansmann Y, Jaulhac B, Kieffer P, et al. Value of PCR, serology, and blood smears for human granulocytic anaplasmosis diagnosis, France. Emerg Infect Dis. 2019;25:996–998.
  • Welinder-Olsson C, Kjellin E, Vaht K, et al. First case of human “Candidatus Neoehrlichia mikurensis” infection in a febrile patient with chronic lymphocytic leukemia. J Clin Microbiol. 2010;48:1956–1959.
  • Wass L, Grankvist A, Mattsson M, et al. Serological reactivity to Anaplasma phagocytophilum in neoehrlichiosis patients. Eur J Clin Microbiol Infect Dis. 2018;37:1673–1678.