Synergistic effects of melatonin and hydrogen sulfide in alleviating cognitive decline and BDNF dysregulation in a rat model of depression

References

• Worthen RJ, Garzon Zighelboim SS, Torres Jaramillo CS, et al. Anti-inflammatory IL-10 administration rescues depression-associated learning and memory deficits in mice. J Neuroinflammation. 2020;17(1):246.
   PubMed Web of Science ®Google Scholar
• Fries GR, Saldana VA, Finnstein J, et al. Molecular pathways of major depressive disorder converge on the synapse. Mol Psychiatry. 2023;28(1):284–297.
   PubMed Web of Science ®Google Scholar
• Tartt AN, B MM, Hen R, et al. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatry. 2022;27:2689–2699. doi: 10.1038/s41380-022-01520-y
   PubMed Web of Science ®Google Scholar
• Tian H, Hu Z, Xu J, et al. The molecular pathophysiology of depression and the new therapeutics. MedComm. 2022 21;3(3):e156. doi: 10.1002/mco2.156
   PubMedGoogle Scholar
• Park SC, Kim D. The centrality of depression and anxiety symptoms in major depressive disorder determined using a network analysis. J Affective Disorders. 2020;271:19–26. doi: 10.1016/j.jad.2020.03.078
   PubMed Web of Science ®Google Scholar
• Kriesche D, Woll CFJ, Tschentscher N, et al. Neurocognitive deficits in depression: a systematic review of cognitive impairment in the acute and remitted state. Eur Arch Psychiatry Clin Neurosci. 2023;273(5):1105–1128.
   PubMed Web of Science ®Google Scholar
• Pan Z, Park C, Brietzke E, et al. Cognitive impairment in major depressive disorder. CNS Spectr. 2019;24(1):22–29.
   PubMed Web of Science ®Google Scholar
• Zhao YT, Zhang L, Yin H, et al. Hydroxytyrosol alleviates oxidative stress and neuroinflammation and enhances hippocampal neurotrophic signaling to improve stress-induced depressive behaviors in mice. Food Funct. 2021;12(12):5478–5487.
   PubMed Web of Science ®Google Scholar
• Tirichen H, Yaigoub H, Xu W, et al. Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress. Front physiol. 2021;12:398. doi: 10.3389/fphys.2021.627837
   Web of Science ®Google Scholar
• Miyanishi H, Nitta A. A role of BDNF in the depression pathogenesis and a potential target as antidepressant: the modulator of stress sensitivity “Shati/Nat8l-BDNF system” in the Dorsal Striatum. Pharmaceuticals. 2021;14(9):889. doi: 10.3390/ph14090889
   Web of Science ®Google Scholar
• Shaohua X, Yiyun L, Juncai P, et al. Chronic stress in a rat model of depression disturbs the Glutamine–Glutamate–GABA cycle in the Striatum, Hippocampus, and Cerebellum. Neuropsychiatr Dis Treat. 2021;16:557–570. doi: 10.2147/NDT.S245282
   Web of Science ®Google Scholar
• Lee BH, Kim YK. The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investigation. 2010 Dec;7(4):231–235. 2010 Nov 23. Epub: 10.4306/pi.2010.7.4.231
   PubMed Web of Science ®Google Scholar
• Chen BH, Park JH, Lee TK, et al. Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus. Chem Biol Interact. 2018;285(285):8–13.
   PubMedGoogle Scholar
• Mohseni F, Bagheri F, Rafaiee R, et al. Hydrogen sulfide improves spatial memory impairment via increases of BDNF expression and hippocampal neurogenesis following early postnatal alcohol exposure. Physiol Behav. 2020;215:112784. doi: 10.1016/j.physbeh.2019.112784
   PubMed Web of Science ®Google Scholar
• Rehman SU, Ikram M, Ullah N, et al. Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB signaling. Cells. 2019;8(7):760. doi: 10.3390/cells8070760
   PubMed Web of Science ®Google Scholar
• Shokri-Mashhadi N, Darand M, Rouhani MH, et al. Effects of melatonin supplementation on BDNF concentrations and depression: A systematic review and meta-analysis of randomized controlled trials. Behav Brain Res. 2023;436:114083. doi: 10.1016/j.bbr.2022.114083
   PubMed Web of Science ®Google Scholar
• Chen W-L, Xie B, Zhang C, et al. Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in behavioral models of depression and anxiety. Behav Pharmacol. 2013;24(7):590–597.
   PubMed Web of Science ®Google Scholar
• Liu SY, Li D, Zeng H-Y, et al. Hydrogen sulfide inhibits chronic unpredictable mild stress-induced depressive-like behavior by upregulation of Sirt-1: involvement in suppression of hippocampal endoplasmic reticulum stress. Int J Neuropsychopharmacol. 2017;20(11):867–876.
   PubMed Web of Science ®Google Scholar
• Xu S, Liu Y, Pu J, et al. Chronic stress in a rat model of depression disturbs the Glutamine-Glutamate-GABA cycle in the striatum, hippocampus, and cerebellum. Neuropsychiatr Dis Treat. 2020;16:557–570. doi: 10.2147/NDT.S245282
   PubMed Web of Science ®Google Scholar
• Bikri S, Talhaoui A, Fath N, et al. Insulin supplemented with phenolic fraction concentrates displays anxiolytic and antidepressant-like properties with reductions of oxidative brain damage in chronically stressed diabetic rats. J Herbmed Pharmacol. 2022a;11(4):562–574.
   Google Scholar
• Bikri S, Fath N, El Aboubi M, et al. Phenolic fraction concentrates supplementation ameliorates learning and memory impairments in chronically stressed streptozotocin-diabetic rats by reducing brain tumor necrosis factor-α. J Herbmed Pharmacol. 2022b;11(4):592–603.
   Google Scholar
• Benmhammed H, El Hayek S, Nassiri A, et al. Effects of lipopolysaccharide administration and maternal deprivation on anxiety and depressive symptoms in male and female Wistar rats: Neurobehavioral and biochemical assessments. Behav Brain Res. 2019;362:46–55. doi: 10.1016/j.bbr.2019.01.005
   PubMed Web of Science ®Google Scholar
• Beauchamp C, Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem. 1971;44(1):276–287. doi: 10.1016/0003-2697(71)90370-8
   PubMed Web of Science ®Google Scholar
• Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990;186:421–431. doi: 10.1016/0076-6879(90)86135-i
   PubMed Web of Science ®Google Scholar
• Chao CC, Hu S, Molitor TW, et al. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol. 1992;149(8):2736–2741.
   PubMed Web of Science ®Google Scholar
• Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72(1–2):248–254. doi: 10.1016/0003-2697(76)90527-3
   PubMed Web of Science ®Google Scholar
• Youssef B, Ramadan KS, ElShebiney S, et al. Antidepressant-like effects of aqueous extracts of miswak (Salvadora persica) and date palm (Phoenix dactylifera) on depression-like behaviors using CUMS model in male rats. J Food Biochem. 2022;46(8):e14164.
   PubMed Web of Science ®Google Scholar
• Wang M, Zhu J, Pan Y, et al. Hydrogen sulfide functions as a neuromodulator to regulate striatal neurotransmission in a mouse model of P arkinson’s disease. J Neurosci Res. 2015;93(3):487–494.
   PubMed Web of Science ®Google Scholar
• Tang ZJ, Zou W, Yuan J, et al. Antidepressant-like and anxiolytic-like effects of hydrogen sulfide in streptozotocin-induced diabetic rats through inhibition of hippocampal oxidative stress. Behav Pharmacol. 2015;26(5):427–435. doi: 10.1097/FBP.0000000000000143
   PubMed Web of Science ®Google Scholar
• Stefanovic B, Spasojevic N, Jovanovic P, et al. Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase a levels. Eur Neuropsychopharmacol. 2016;26(10):1629–1637. doi: 10.1016/j.euroneuro.2016.07.005
   PubMed Web of Science ®Google Scholar
• Detanico BC, Piato AL, Freitas JJ, et al. Antidepressant-like effects of melatonin in the mouse chronic mild stress model. Eur J Pharmacol. 2009;607(1–3):121–125.
   PubMed Web of Science ®Google Scholar
• Vega-Rivera NM, Ortiz-López L, Granados-Juárez A, et al. Melatonin reverses the depression-associated behaviour and regulates microglia, fractalkine expression and neurogenesis in adult mice exposed to chronic mild stress. Neuroscience. 2020;440:316–336. doi: 10.1016/j.neuroscience.2020.05.014
   PubMed Web of Science ®Google Scholar
• Wang YQ, Jiang YJ, Zou MS, et al. Antidepressant actions of melatonin and melatonin receptor agonist: Focus on pathophysiology and treatment. Behav Brain Res. 2022;420:113724. doi: 10.1016/j.bbr.2021.113724
   PubMed Web of Science ®Google Scholar
• Stephens MA, Wand G. Stress and the HPA axis: role of glucocorticoids in alcohol dependence. Alcohol Res. 2012;34(4):468–483.
   PubMed Web of Science ®Google Scholar
• Liao D, Lv C, Cao L, et al. Curcumin attenuates chronic unpredictable mild stress-induced depressive-like behaviors via restoring changes in oxidative stress and the activation of Nrf2 signaling pathway in rats. Oxidative medicine and cellular longevity 9268083. Oxid Med Cell Longevity. 2020;2020:1–11. doi: 10.1155/2020/9268083
   Web of Science ®Google Scholar
• Quan W, Liu F, Zhang Y, et al. Antidepressant-like effects of magnesium lithospermate B in a rat model of chronic unpredictable stress. Pharm Biol. 2015;53(8):1168–1175. doi: 10.3109/13880209.2014.967783
   PubMed Web of Science ®Google Scholar
• Wang S, Xu X, Ju X, et al. Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus. Neuroreport. 2021;32(1):8–15. doi: 10.1097/WNR.0000000000001554
   PubMed Web of Science ®Google Scholar
• Gomaa AM, Galal HM, Abou-Elgait AT. Neuroprotective effects of melatonin administration against chronic immobilization stress in rats. Int J Physiol Physiol Pharmacol. 2017 Apr 15;9(2):16–27.
   Google Scholar
• Torres-Farfan C, Richter HG, Rojas-Garcia P, et al. mt1 Melatonin receptor in the primate adrenal gland: inhibition of adrenocorticotropin-stimulated cortisol production by melatonin. J Clin Endocrinol Metab. 2003;88:450–458.
   PubMed Web of Science ®Google Scholar
• Dello Russo C, Tringali G, Ragazzoni E, et al. Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: in vitro and in vivo studies in the rat. J Neuroendocrinol. 2000 Mar;12(3):225–233. doi: 10.1046/j.1365-2826.2000.00441.x
   PubMed Web of Science ®Google Scholar
• Chaudhary P, Janmeda P, Docea AO, et al. Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Front Chem. 2023;11:1158198. doi: 10.3389/fchem.2023.1158198
   PubMed Web of Science ®Google Scholar
• Cobley JN, Fiorello ML, Bailey DM. 13 reasons why the brain is susceptible to oxidative stress. Redox Biol. 2018;15:490–503. doi: 10.1016/j.redox.2018.01.008
   PubMed Web of Science ®Google Scholar
• Juszczyk G, Mikulska J, Kasperek K, et al. Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer’s disease: the role of antioxidants in prevention and treatment. Antioxidants (Basel). 2021;10(9):1439.
   PubMedGoogle Scholar
• Hassamal S. Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories. Front Psychiatry. 2023;14:1130989. doi: 10.3389/fpsyt.2023.1130989
   PubMed Web of Science ®Google Scholar
• Harrison NA, Cercignani M, Voon V, et al. Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology. 2015;40(4):831–838.
   PubMed Web of Science ®Google Scholar
• Bakunina N, Pariante CM, Zunszain PA. Immune mechanisms linked to depression via oxidative stress and neuroprogression. Immunology. 2015;144(3):365–373. doi: 10.1111/imm.12443
   PubMed Web of Science ®Google Scholar
• Bajpai A, Verma AK, Srivastava M, et al. Oxidative stress and major depression. J Clin Diagn Res: JCDR. 2014;8(12):CC04–CC7.
   PubMedGoogle Scholar
• Liu Y, Ho RC-M, Mak A. Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affective Disorders. 2012;139(3):230–239. doi: 10.1016/j.jad.2011.08.003
   PubMed Web of Science ®Google Scholar
• Lucca G, Comim CM, Valvassori SS, et al. Effects of chronic mild stress on the oxidative parameters in the rat brain. Neurochem Int. 2009 May-Jun;54(5–6):358–362. doi: 10.1016/j.neuint.2009.01.001
   PubMed Web of Science ®Google Scholar
• Ogłodek EA, Just MJ, Szromek AR, et al. Melatonin and neurotrophins NT-3, BDNF, NGF in patients with varying levels of depression severity. Pharmacol Rep. 2016;68(5):945–951.
   PubMed Web of Science ®Google Scholar
• Rosales-Corral S, Tan DX, Reiter RJ, et al. Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E. J Pineal Res. 2003;35(2):80–84. doi: 10.1034/j.1600-079x.2003.00057.x
   PubMed Web of Science ®Google Scholar
• Hu M, Zou W, Wang CY, et al. Hydrogen sulfide protects against chronic unpredictable mild stress-induced oxidative stress in hippocampus by upregulation of BDNF-TrkB pathway. Oxid Med Cell Longev. 2016;2016:2153745. doi: 10.1155/2016/2153745
   PubMed Web of Science ®Google Scholar
• Sunzini F, De Stefano S, Chimenti MS, et al. Hydrogen sulfide as potential regulatory gasotransmitter in arthritic diseases. Int J Mol Sci. 2020;21(4):1180.
   PubMed Web of Science ®Google Scholar
• Ali M, Fahmy M, Haggag W, et al. Evaluation of cognitive impairment in patients with major depressive disorder in remission. Middle East Curr Psychiatry. 2021;28(1). doi: 10.1186/s43045-021-00149-x
   Google Scholar
• Liu J, Chen Y, Xie X, et al. The percentage of cognitive impairment in patients with major depressive disorder over the course of the depression: A longitudinal study. J Affect Disord. 2023;329(329):511–518.
   PubMedGoogle Scholar
• Dobielska M, Bartosik NK, Zyzik KA, et al. Mechanisms of cognitive impairment in depression. May probiotics help? Front Psychiatry. 2022;13(13):904426.
   PubMedGoogle Scholar
• Alqurashi GK, Hindi EA, Zayed MA, et al. The impact of chronic unpredictable mild stress-induced depression on spatial, recognition and reference memory tasks in mice: behavioral and histological study. Behav Sci (Basel). 2022;12(6):166.
   PubMedGoogle Scholar
• Ulrich-Lai YM, Figueiredo HF, Ostrander MM, et al. Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner. Am J Physiol Endocrinol Metab. 2006;291(5):E965–E973. doi: 10.1152/ajpendo.00070.2006
   PubMed Web of Science ®Google Scholar
• Abe K, Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci. 1996;16(3):1066–1071. doi: 10.1523/JNEUROSCI.16-03-01066.1996
   PubMed Web of Science ®Google Scholar
• Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science. 2012;338(6103):68–72. doi: 10.1126/science.1222939
   PubMed Web of Science ®Google Scholar
• Tan H, Zou W, Jiang J, et al. Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus. Acta Biochim Biophys Sin (Shanghai). 2015;47(4):285–291. doi: 10.1093/abbs/gmv009
   PubMed Web of Science ®Google Scholar
• Wei HJ, Li X, Tang XQ. Therapeutic benefits of H₂S in Alzheimer’s disease. J Clin Neurosci. 2014;21(10):1665–1669. doi: 10.1016/j.jocn.2014.01.006
   PubMed Web of Science ®Google Scholar
• Fang X, Han Q, Li S, et al. Melatonin attenuates spatial learning and memory dysfunction in developing rats by suppressing isoflurane-induced endoplasmic reticulum stress via the SIRT1/Mfn2/PERK signaling pathway. Heliyon. 2022;8(9):e10326. doi: 10.1016/j.heliyon.2022.e10326
   PubMed Web of Science ®Google Scholar
• Dera HA, Alassiri M, Kahtani RA, et al. Melatonin attenuates cerebral hypoperfusion-induced hippocampal damage and memory deficits in rats by suppressing TRPM7 channels. Saudi J Biol Sci. 2022;29(4):2958–2968.
   PubMed Web of Science ®Google Scholar
• Gonzalez MC, Radiske A, Cammarota M. On the involvement of BDNF signaling in memory reconsolidation. Front Cell Neurosci. 2019;13(13):383. doi: 10.3389/fncel.2019.00383
   PubMedGoogle Scholar
• Ávila-Villanueva M, Gómez-Ramírez J, Maestú F, et al. The role of chronic stress as a trigger for the Alzheimer disease continuum. Front Aging Neurosci. 2020;12:561504. doi: 10.3389/fnagi.2020.561504
   PubMed Web of Science ®Google Scholar
• Miranda-Riestra A, Estrada-Reyes R, Torres-Sanchez ED, et al. Melatonin: a neurotrophic factor? Molecules (Basel, Switzerland). 2022;27(22):7742. doi: 10.3390/molecules27227742
   PubMed Web of Science ®Google Scholar
• Labban S, Alshehri FS, Kurdi M, et al. Melatonin improves short-term spatial memory in a mouse model of Alzheimer’s disease. Degener Neurol Neuromuscul Dis. 2021;11:15–27. doi: 10.2147/DNND.S291172
   PubMed Web of Science ®Google Scholar
• Shu-Yun L, Dan L, Hai-Ying Z, et al. Hydrogen sulfide inhibits chronic unpredictable mild stress-induced depressive-like behavior by upregulation of Sirt-1: involvement in suppression of hippocampal endoplasmic reticulum stress. Int J Neuropsychopharmacol. 2017;20(11):867–876.
   PubMed Web of Science ®Google Scholar