Exploring the epigenome to identify biological links between the urban environment and neurodegenerative disease: an evidence review

References

• Adekomi, D., 2017. Lead induces inflammation and neurodegenerative changes in the rat medial prefrontal cortex. Anatomt-an international journal of experimental and clinical anatomy, 11 (2), 79–86. doi:10.2399/ana.17.015.
   Google Scholar
• Ahmad, W., et al., 2021. Toxic and heavy metals contamination assessment in soil and water to evaluate human health risk. Scientific reports, 11 (1), 17006. doi:10.1038/s41598-021-94616-4.
   PubMed Web of Science ®Google Scholar
• Alameda, L., et al., 2022. Can epigenetics shine a light on the biological pathways underlying major mental disorders? Psychological medicine, 52 (9), 1645–1665. doi:10.1017/S0033291721005559.
   PubMed Web of Science ®Google Scholar
• Alemany, S., et al., 2021. Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals. Environment international, 157, 106864. doi:10.1016/j.envint.2021.106864.
   PubMed Web of Science ®Google Scholar
• Alfano, R., et al., 2023. Epigenome-wide analysis of maternal exposure to green space during gestation and cord blood DNA methylation in the ENVIRONAGE cohort. Environmental research, 216, 114828. doi:10.1016/j.envres.2022.114828.
   PubMed Web of Science ®Google Scholar
• Alghamdi, B.S., 2018. The neuroprotective role of melatonin in neurological disorders. Journal of neuroscience research, 96 (7), 1136–1149. doi:10.1002/jnr.24220.
   PubMed Web of Science ®Google Scholar
• Athanasopoulos, D., Karagiannis, G., and Tsolaki, M., 2016. Recent findings in Alzheimer disease and nutrition focusing on epigenetics. Advances in nutrition, 7 (5), 917–927. doi:10.3945/an.116.012229.
   PubMed Web of Science ®Google Scholar
• Atkinson, R.W., et al., 2010. Urban ambient particle metrics and health: a time-series analysis. Epidemiology, 21 (4), 501–511. doi:10.1097/EDE.0b013e3181debc88.
   PubMed Web of Science ®Google Scholar
• Bagepally, B.S., et al., 2021. Association between aluminium exposure and cognitive functions: a systematic review and meta-analysis. Chemosphere, 268, 128831. doi:10.1016/j.chemosphere.2020.128831
   PubMed Web of Science ®Google Scholar
• Bakulski, K.M., et al., 2020. Heavy metals exposure and Alzheimer’s disease and related dementias. Journal of Alzheimer’s disease: JAD, 76 (4), 1215–1242. doi:10.3233/JAD-200282.
   PubMed Web of Science ®Google Scholar
• Baranyi, G., et al., 2022. Life-course exposure to air pollution and biological ageing in the Lothian birth cohort 1936. Environment international, 169, 107501. doi:10.1016/j.envint.2022.107501.
   PubMed Web of Science ®Google Scholar
• Bell, C.G., et al., 2019. DNA methylation aging clocks: challenges and recommendations. Genome biology, 20 (1), 249. doi:10.1186/s13059-019-1824-y.
   PubMed Web of Science ®Google Scholar
• Belsky, D.W., et al., 2020. Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. Elife, 9. doi:10.7554/eLife.54870.
   PubMed Web of Science ®Google Scholar
• Benabed, A. and Boulbair, A., 2022. PM10, PM2.5, PM1, and PM0.1 resuspension due to human walking. Air quality, atmosphere, & health, 15 (9), 1547–1556. doi:10.1007/s11869-022-01201-3.
   PubMed Web of Science ®Google Scholar
• Berson, A., et al., 2018. Epigenetic Regulation in Neurodegenerative Diseases. Trends in neurosciences, 41 (9), 587–598. doi:10.1016/j.tins.2018.05.005.
   PubMed Web of Science ®Google Scholar
• Besser, L., 2021. Outdoor green space exposure and brain health measures related to Alzheimer’s disease: a rapid review. BMJ open, 11 (5), e043456. doi:10.1136/bmjopen-2020-043456.
   PubMed Web of Science ®Google Scholar
• Besser, L.M., et al., 2021. Associations between neighborhood park access and longitudinal change in cognition in older adults: the multi-ethnic study of atherosclerosis. Journal of Alzheimer’s disease, 82 (1), - 233. doi:10.3233/JAD-210370.
   PubMed Web of Science ®Google Scholar
• Beyer, K.M., et al., 2014. Exposure to neighborhood green space and mental health: evidence from the survey of the health of Wisconsin. International journal of environmental research and public health, 11 (3), 3453–3472. doi:10.3390/ijerph110303453.
   PubMed Web of Science ®Google Scholar
• Bondy, S.C. and Campbell, A., 2017. Water quality and brain function. International journal of environmental research and public health, 15 (1), 2. doi:10.3390/ijerph15010002.
   PubMed Web of Science ®Google Scholar
• Burgess, S., et al., 2015. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. European journal of epidemiology, 30 (7), 543–552. doi:10.1007/s10654-015-0011-z.
   PubMed Web of Science ®Google Scholar
• Burgess, S., Thompson, S.G., and Collaboration, C.C.G., 2011. Avoiding bias from weak instruments in Mendelian randomization studies. International journal of epidemiology, 40 (3), 755–764. doi:10.1093/ije/dyr036.
   PubMed Web of Science ®Google Scholar
• Cabral Pinto, M.M.S., et al., 2018. Human predisposition to cognitive impairment and its relation with environmental exposure to potentially toxic elements. Environmental geochemistry and health, 40 (5), 1767–1784. doi:10.1007/s10653-017-9928-3.
   PubMed Web of Science ®Google Scholar
• Caicedo, A., Mayorga, M., and Estrada, M., 2021. Modelling individual perception of barriers to bike use. Transportation Research Procedia, 58, 293–300. doi:10.1016/j.trpro.2021.11.040
   Google Scholar
• Calderón-Garcidueñas, L., et al., 2020. Reduced repressive epigenetic marks, increased DNA damage and Alzheimer’s disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution. Environmental research, 183, 109226. doi:10.1016/j.envres.2020.109226.
   PubMed Web of Science ®Google Scholar
• Campagna, M.P., et al., 2021. Epigenome-wide association studies: current knowledge, strategies and recommendations. Clinical epigenetics, 13 (1), 214. doi:10.1186/s13148-021-01200-8.
   PubMed Web of Science ®Google Scholar
• Carek, P.J., Laibstain, S.E., and Carek, S.M., 2011. Exercise for the treatment of depression and anxiety. The international journal of psychiatry in medicine, 41 (1), 15–28. doi:10.2190/PM.41.1.c.
   PubMed Web of Science ®Google Scholar
• Cartwright, N., 2009. What are randomised controlled trials good for? Philosophical studies, 147 (1), 59. doi:10.1007/s11098-009-9450-2.
   Web of Science ®Google Scholar
• Cazaly, E., et al., 2019. Making sense of the epigenome using data integration approaches. Frontiers in pharmacology, 10, 126. doi:10.3389/fphar.2019.00126.
   PubMed Web of Science ®Google Scholar
• Chandra, M., et al., 2022. Air pollution and cognitive impairment across the life course in humans: a systematic review with specific focus on income level of study area. International journal of environmental research and public health, 19 (3), 1405. doi:10.3390/ijerph19031405.
   PubMed Web of Science ®Google Scholar
• Chen, H., et al., 2017a. Exposure to ambient air pollution and the incidence of dementia: a population-based cohort study. Environment international, 108, 271–277. doi:10.1016/j.envint.2017.08.020.
   PubMed Web of Science ®Google Scholar
• Chen, H., et al., 2017b. Living near major roads and the incidence of dementia, Parkinson’s disease, and multiple sclerosis: a population-based cohort study. Lancet, 389 (10070), 718–726. doi:10.1016/S0140-6736(16)32399-6.
   PubMed Web of Science ®Google Scholar
• Chen, Y., et al., 2022. Long-term exposure to outdoor light at night and mild cognitive impairment: a nationwide study in Chinese veterans. Science of the total environment, 847, 157441. doi:10.1016/j.scitotenv.2022.157441.
   PubMed Web of Science ®Google Scholar
• Cheng, L., et al., 2019. Active travel for active ageing in China: the role of built environment. Journal of transport geography, 76, 142–152. doi:10.1016/j.jtrangeo.2019.03.010.
   Web of Science ®Google Scholar
• Chi, G.C., et al., 2022. Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the multi-ethnic study of atherosclerosis. Epigenetics, 17 (3), 1900028. doi:10.1080/15592294.2021.1900028.
   Web of Science ®Google Scholar
• Chin-Chan, M., Navarro-Yepes, J., and Quintanilla-Vega, B., 2015. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Frontiers in cellular neuroscience, 9, 124. doi:10.3389/fncel.2015.00124
   PubMed Web of Science ®Google Scholar
• Cho, Y., et al., 2015. Effects of artificial light at night on human health: a literature review of observational and experimental studies applied to exposure assessment. Chronobiology international, 32 (9), 1294–1310. doi:10.3109/07420528.2015.1073158.
   PubMed Web of Science ®Google Scholar
• Clifford, A., et al., 2016. Exposure to air pollution and cognitive functioning across the life course – a systematic literature review. Environmental research, 147, 383–398. doi:10.1016/j.envres.2016.01.018.
   PubMed Web of Science ®Google Scholar
• Colwell, M.L., et al., 2023. Epigenetics and the exposome: DNA methylation as a proxy for health impacts of prenatal environmental exposures. Exposome, 3 (1). doi:10.1093/exposome/osad001.
   PubMedGoogle Scholar
• Cooke, P., Janowitz, H., and Dougherty, S.E., 2022. Neuronal redevelopment and the regeneration of neuromodulatory axons in the adult mammalian central nervous system. Frontiers in cellular neuroscience, 16, 872501. doi:10.3389/fncel.2022.872501
   PubMed Web of Science ®Google Scholar
• Crawford, B., et al., 2018. DNA methylation and inflammation marker profiles associated with a history of depression. Human molecular genetics, 27 (16), 2840–2850. doi:10.1093/hmg/ddy199.
   PubMed Web of Science ®Google Scholar
• Crouch, J., et al., 2022. Epigenetic regulation of cellular senescence. Cells, 11 (4), 672. doi:10.3390/cells11040672.
   PubMed Web of Science ®Google Scholar
• Cui, B., et al., 2012. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology, 238 (2), 122–129. doi:10.1016/j.expneurol.2012.08.028.
   PubMed Web of Science ®Google Scholar
• Dadvand, P., et al., 2012. Surrounding greenness and exposure to air pollution during pregnancy: an analysis of personal monitoring data. Environmental health perspectives, 120 (9), 1286–1290. doi:10.1289/ehp.1104609.
   PubMed Web of Science ®Google Scholar
• Daiber, A., et al., 2020. Oxidative stress and inflammation contribute to traffic noise-induced vascular and cerebral dysfunction via uncoupling of nitric oxide synthases. Redox biology, 34, 101506. doi:10.1016/j.redox.2020.101506.
   PubMed Web of Science ®Google Scholar
• Dashtipour, K., et al., 2017. Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) gene in the cerebral cortex of patients with sporadic Parkinson’s disease. Brain sciences, 7 (7), 74. doi:10.3390/brainsci7070074.
   PubMed Web of Science ®Google Scholar
• Dekkers, K.F., et al., 2016. Blood lipids influence DNA methylation in circulating cells. Genome biology, 17 (1), 138. doi:10.1186/s13059-016-1000-6.
   PubMedGoogle Scholar
• Delgado-Morales, R., et al., 2017. Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders. Clinical epigenetics, 9 (1), 67. doi:10.1186/s13148-017-0365-z.
   PubMedGoogle Scholar
• de Paiva Vianna, K.M., Alves Cardoso, M.R., and Rodrigues, R.M., 2015. Noise pollution and annoyance: an urban soundscapes study. Noise & health, 17 (76), 125–133. doi:10.4103/1463-1741.155833.
   PubMed Web of Science ®Google Scholar
• Didelez, V. and Sheehan, N., 2007. Mendelian randomization as an instrumental variable approach to causal inference. Statistical methods in medical research, 16 (4), 309–330. doi:10.1177/0962280206077743.
   PubMed Web of Science ®Google Scholar
• Di Micco, R., et al., 2021. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nature reviews molecular cell biology, 22 (2), 75–95. doi:10.1038/s41580-020-00314-w.
   PubMed Web of Science ®Google Scholar
• Dominguez, L.J., et al., 2021. Nutrition, physical activity, and other lifestyle factors in the prevention of cognitive decline and dementia. Nutrients, 13 (11), 4080. doi:10.3390/nu13114080.
   PubMed Web of Science ®Google Scholar
• Dong, Y.T., et al., 2020. Silent mating-type information regulation 2 homolog 1 attenuates the neurotoxicity associated with Alzheimer disease via a mechanism which may involve regulation of peroxisome proliferator-activated receptor gamma coactivator 1-α. The American journal of pathology, 190 (7), 1545–1564. doi:10.1016/j.ajpath.2020.03.015.
   PubMed Web of Science ®Google Scholar
• Dumax-Vorzet, A.F., et al., 2015. Cytotoxicity and genotoxicity of urban particulate matter in mammalian cells. Mutagenesis, 30 (5), 621–633. doi:10.1093/mutage/gev025.
   PubMed Web of Science ®Google Scholar
• Duran-Aniotz, C., et al., 2021. Amyloid pathology arrangements in Alzheimer’s disease brains modulate in vivo seeding capability. Acta neuropathologica communications, 9 (1), 56. doi:10.1186/s40478-021-01155-0.
   PubMed Web of Science ®Google Scholar
• Escobar, C., et al., 2011. Circadian disruption leads to loss of homeostasis and disease. Sleep disorders, 2011, 1–8. doi:10.1155/2011/964510
   Google Scholar
• Eze, I.C., et al., 2020. Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study. Environmental health perspectives, 128 (6), 67003. doi:10.1289/EHP6174.
   PubMed Web of Science ®Google Scholar
• Fathabadi, B., et al., 2018. Comparison of blood lead levels in patients with Alzheimer’s disease and healthy people. American journal of Alzheimer’s disease and other dementias, 33 (8), 541–547. doi:10.1177/1533317518794032.
   PubMed Web of Science ®Google Scholar
• Fernandes, J., Arida, R.M., and Gomez-Pinilla, F., 2017. Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neuroscience & biobehavioral reviews, 80, 443–456. doi:10.1016/j.neubiorev.2017.06.012
   PubMed Web of Science ®Google Scholar
• Fiorito, G., et al., 2017. Social adversity and epigenetic aging: a multi-cohort study on socioeconomic differences in peripheral blood DNA methylation. Scientific reports, 7 (1), 16266. doi:10.1038/s41598-017-16391-5.
   PubMed Web of Science ®Google Scholar
• Flies, E.J., et al., 2019. Urban-associated diseases: candidate diseases, environmental risk factors, and a path forward. Environment international, 133, 105187. doi:10.1016/j.envint.2019.105187.
   PubMed Web of Science ®Google Scholar
• Fraser, S.D.S. and Lock, K., 2011. Cycling for transport and public health: a systematic review of the effect of the environment on cycling. European journal of public health, 21 (6), 738–743. doi:10.1093/eurpub/ckq145.
   PubMed Web of Science ®Google Scholar
• Freydenzon, A., et al., 2022. Association between DNA methylation variability and self-reported exposure to heavy metals. Scientific Reports, 12 (1), 10582. doi:10.1038/s41598-022-13892-w.
   PubMed Web of Science ®Google Scholar
• Fuller, R., et al., 2022. Pollution and health: a progress update. The lancet planet health, 6 (6), e535–e47. doi:10.1016/S2542-5196(22)00090-0.
   PubMedGoogle Scholar
• Gaine, M.E., Chatterjee, S., and Abel, T., 2018. Sleep deprivation and the epigenome. Frontiers in neural circuits, 12, 14. doi:10.3389/fncir.2018.00014
   PubMed Web of Science ®Google Scholar
• Gao, X., et al., 2022. Short-term exposure of PM(2.5) and epigenetic aging: a quasi-experimental study. Environmental science & technology, 56 (20), 14690–14700. doi:10.1021/acs.est.2c05534.
   PubMed Web of Science ®Google Scholar
• Gascon, M., et al., 2015. Mental health benefits of long-term exposure to residential green and blue spaces: a systematic review. International journal of environmental research and public health, 12 (4), 4354–4379. [Internet]. doi:10.3390/ijerph120404354.
   PubMed Web of Science ®Google Scholar
• Gibney, E.R. and Nolan, C.M., 2010. Epigenetics and gene expression. Heredity, 105 (1), 4–13. doi:10.1038/hdy.2010.54.
   PubMed Web of Science ®Google Scholar
• Gidlöf-Gunnarsson, A. and Öhrström, E., 2007. Noise and well-being in urban residential environments: the potential role of perceived availability to nearby green areas. Landscape and urban planning, 83 (2), 115–126. doi:10.1016/j.landurbplan.2007.03.003.
   Web of Science ®Google Scholar
• Gidlow, C.J., et al., 2016a. Natural environments and chronic stress measured by hair cortisol. Landscape and urban planning, 148, 61–67. doi:10.1016/j.landurbplan.2015.12.009.
   Web of Science ®Google Scholar
• Gidlow, C.J., et al., 2016b. Where to put your best foot forward: psycho-physiological responses to walking in natural and urban environments. Journal of environmental psychology, 45, 22–29. doi:10.1016/j.jenvp.2015.11.003.
   Web of Science ®Google Scholar
• Gondalia, R., et al., 2019. Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation. Environment international, 132, 104723. doi:10.1016/j.envint.2019.03.071.
   PubMed Web of Science ®Google Scholar
• Gonzales, M.M., et al., 2022. Biological aging processes underlying cognitive decline and neurodegenerative disease. Journal of clinical investigation, 132 (10). doi:10.1172/JCI158453.
   PubMed Web of Science ®Google Scholar
• Grigoratos, T. and Martini, G., 2015. Brake wear particle emissions: a review. Environmental science and pollution research, 22 (4), 2491–2504. doi:10.1007/s11356-014-3696-8.
   PubMed Web of Science ®Google Scholar
• Grodstein, F., et al., 2021. The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes. Neurobiology of disease, 157, 105428. doi:10.1016/j.nbd.2021.105428.
   PubMed Web of Science ®Google Scholar
• Guillaumet-Adkins, A., et al., 2017. Epigenetics and oxidative stress in aging. Oxidative medicine and cellular longevity, 2017, 9175806. doi:10.1155/2017/9175806
   PubMedGoogle Scholar
• Hahad, O., et al., 2020. Ambient air pollution increases the risk of cerebrovascular and neuropsychiatric disorders through induction of inflammation and oxidative stress. International journal of molecular sciences, 21 (12), 4306. doi:10.3390/ijms21124306.
   PubMed Web of Science ®Google Scholar
• Hajat, A., et al., 2021. Confounding by socioeconomic status in epidemiological studies of air pollution and health: challenges and opportunities. Environmental health perspectives, 129 (6), 65001. doi:10.1289/EHP7980.
   PubMed Web of Science ®Google Scholar
• Halperin, D., 2014. Environmental noise and sleep disturbances: a threat to health? Sleep science, 7 (4), 209–212. doi:10.1016/j.slsci.2014.11.003.
   PubMedGoogle Scholar
• Hannah, C.-C., Eric, T., and Glen, E.D., 2015. Access to green space, physical activity and mental health: a twin study. Journal of epidemiology and community health, 69 (6), 523. doi:10.1136/jech-2014-204667.
   PubMed Web of Science ®Google Scholar
• Hannon, E., et al., 2018. Characterizing genetic and environmental influences on variable DNA methylation using monozygotic and dizygotic twins. PLoS genetics, 14 (8), e1007544. doi:10.1371/journal.pgen.1007544.
   PubMed Web of Science ®Google Scholar
• Hannum, G., et al., 2013. Genome-wide methylation profiles reveal quantitative views of human aging rates. Molecular cell, 49 (2), 359–367. doi:10.1016/j.molcel.2012.10.016.
   PubMed Web of Science ®Google Scholar
• Hara, Y., et al., 2015. Estrogen effects on cognitive and synaptic health over the lifecourse. Physiological reviews, 95 (3), 785–807. doi:10.1152/physrev.00036.2014.
   PubMed Web of Science ®Google Scholar
• Hardeland, R., 2012. Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. Scientific world journal, 2012, 640389. doi:10.1100/2012/640389
   Web of Science ®Google Scholar
• Hasan, M., et al., 2022. Urban green space mediates spatiotemporal variation in land surface temperature: a case study of an urbanized city, Bangladesh. Environmental science and pollution research international, 29 (24), 36376–36391. doi:10.1007/s11356-021-17480-9.
   PubMed Web of Science ®Google Scholar
• He, C., et al., 2021. Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al. Molecular therapy - nucleic acids, 26, 1401–1417. doi:10.1016/j.omtn.2021.11.010.
   Google Scholar
• Heusinkveld, H.J., et al., 2016. Neurodegenerative and neurological disorders by small inhaled particles. NeuroToxicology, 56, 94–106. doi:10.1016/j.neuro.2016.07.007.
   PubMed Web of Science ®Google Scholar
• Hing, B., et al., 2018. Chronic social stress induces DNA methylation changes at an evolutionary conserved intergenic region in chromosome X. Epigenetics, 13 (6), 627–641. doi:10.1080/15592294.2018.1486654.
   PubMed Web of Science ®Google Scholar
• Ho, S.M., et al., 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR journal / national research council, institute of laboratory animal resources, 53 (3–4), 289–305. doi:10.1093/ilar.53.3-4.289.
   PubMed Web of Science ®Google Scholar
• Holliday, K.M., et al., 2022. Gaseous air pollutants and DNA methylation in a methylome-wide association study of an ethnically and environmentally diverse population of U.S. adults. Environmental research, 212 (Pt C), 113360. doi:10.1016/j.envres.2022.113360.
   PubMedGoogle Scholar
• Holmström, K.M. and Finkel, T., 2014. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nature reviews molecular cell biology, 15 (6), 411–421. doi:10.1038/nrm3801.
   PubMed Web of Science ®Google Scholar
• Horvath, S., 2013. DNA methylation age of human tissues and cell types. Genome biology, 14 (10), 3156. doi:10.1186/gb-2013-14-10-r115.
   Web of Science ®Google Scholar
• Horvath, S. and Raj, K., 2018. DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature reviews genetics, 19 (6), 371–384. doi:10.1038/s41576-018-0004-3.
   PubMed Web of Science ®Google Scholar
• Hou, Y., et al., 2019. Ageing as a risk factor for neurodegenerative disease. Nature reviews neurology, 15 (10), 565–581. doi:10.1038/s41582-019-0244-7.
   PubMed Web of Science ®Google Scholar
• Huang, Y.T., Hong, F.F., and Yang, S.L., 2021. Atherosclerosis: the culprit and Co-victim of vascular dementia. Frontiers in neuroscience, 15, 673440. doi:10.3389/fnins.2021.673440
   PubMed Web of Science ®Google Scholar
• Hudec, M., et al., 2020. Epigenetic regulation of circadian rhythm and its possible role in diabetes mellitus. International journal of molecular sciences, 21 (8), 3005. doi:10.3390/ijms21083005.
   PubMed Web of Science ®Google Scholar
• Hui, L., 2017. Assessment of the role of ageing and non-ageing factors in death from non-communicable diseases based on a cumulative frequency model. Scientific reports, 7 (1), 8159. doi:10.1038/s41598-017-08539-0.
   PubMedGoogle Scholar
• Hunter, D.J., et al., 2019. Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation. Epigenetics, 14 (3), 294–309. doi:10.1080/15592294.2019.1582276.
   PubMed Web of Science ®Google Scholar
• Hwang, J.Y., Aromolaran, K.A., and Zukin, R.S., 2017. The emerging field of epigenetics in neurodegeneration and neuroprotection. Nature reviews Neuroscience, 18 (6), 347–361. doi:10.1038/nrn.2017.46.
   PubMed Web of Science ®Google Scholar
• Hystad, P., et al., 2019. Green space associations with mental health and cognitive function: results from the Quebec CARTaGENE cohort. Environmental Epidemiology, 3 (1), e040. (no pagination): doi:10.1097/EE9.0000000000000040.
   Google Scholar
• Iso-Markku, P., et al., 2022. Physical activity as a protective factor for dementia and Alzheimer’s disease: systematic review, meta-analysis and quality assessment of cohort and case-control studies. British journal of sports medicine, 56 (12), 701–709. doi:10.1136/bjsports-2021-104981.
   PubMed Web of Science ®Google Scholar
• Iwińska, K., et al., 2018. Cycling in Warsaw, Poland – perceived enablers and barriers according to cyclists and non-cyclists. Transportation research part A: Policy and practice, 113, 291–301. doi:10.1016/j.tra.2018.04.014
   PubMed Web of Science ®Google Scholar
• Jain, P., et al., 2022. Analysis of epigenetic age acceleration and healthy longevity among older US women. JAMA Network Open, 5 (7), e2223285. doi:10.1001/jamanetworkopen.2022.23285.
   PubMed Web of Science ®Google Scholar
• Jennings, V. and Bamkole, O., 2019. The relationship between social cohesion and urban green space: an avenue for health promotion. International journal of environmental research and public health, 16 (3), 452. [Internet]: doi:10.3390/ijerph16030452.
   PubMed Web of Science ®Google Scholar
• Jia, J., et al., 2023. Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study. BMJ: British medical journal, 380, e072691. doi:10.1136/bmj-2022-072691.
   Web of Science ®Google Scholar
• Jirtle, R.L. and Skinner, M.K., 2007. Environmental epigenomics and disease susceptibility. Nature reviews genetics, 8 (4), 253–262. doi:10.1038/nrg2045.
   PubMed Web of Science ®Google Scholar
• Jo, S., et al., 2021. Association of NO2 and other air pollution exposures with the risk of Parkinson disease. JAMA neurology, 78 (7), 800–808. doi:10.1001/jamaneurol.2021.1335.
   PubMed Web of Science ®Google Scholar
• Junior, D.P.M., Bueno, C., and da Silva, C.M., 2022. The effect of urban green spaces on reduction of particulate matter concentration. Bulletin of environmental contamination and toxicology, 108 (6), 1104–1110. doi:10.1007/s00128-022-03460-3.
   PubMed Web of Science ®Google Scholar
• Ju, Y. and Tam, K.Y., 2022. Pathological mechanisms and therapeutic strategies for Alzheimer’s disease. Neural regeneration research, 17 (3), 543–549. doi:10.4103/1673-5374.320970.
   PubMed Web of Science ®Google Scholar
• Kalia, V., et al., 2022. An exposomic framework to uncover environmental drivers of aging. Exposome, 2 (1). doi:10.1093/exposome/osac002.
   PubMedGoogle Scholar
• Kandlur, A., Satyamoorthy, K., and Gangadharan, G., 2020. Oxidative stress in cognitive and epigenetic aging: a retrospective glance. Frontiers in molecular neuroscience, 13, 41. doi:10.3389/fnmol.2020.00041
   PubMed Web of Science ®Google Scholar
• Kanherkar, R.R., Bhatia-Dey, N., and Csoka, A.B., 2014. Epigenetics across the human lifespan. Frontiers in cell and developmental biology, 2, 49. doi:10.3389/fcell.2014.00049
   PubMed Web of Science ®Google Scholar
• Kao, C.F., et al., 2020. Gene-based association analysis suggests association of HTR2A with antidepressant treatment response in depressed patients. Frontiers in pharmacology, 11, 559601. doi:10.3389/fphar.2020.559601.
   PubMed Web of Science ®Google Scholar
• Katayama, O., et al., 2020. The association between neighborhood amenities and cognitive function: role of lifestyle activities. Journal of clinical medicine, 9 (7), 2109. doi:10.3390/jcm9072109.
   PubMed Web of Science ®Google Scholar
• Kawahara, M. and Kato-Negishi, M., 2011. Link between aluminum and the pathogenesis of Alzheimer’s disease: the integration of the aluminum and amyloid cascade hypotheses. International journal of Alzheimer’s disease, 2011, 1–17. doi:10.4061/2011/276393
   Google Scholar
• Kempf, A., et al., 2019. A potassium channel β-subunit couples mitochondrial electron transport to sleep. Nature, 568 (7751), 230–234. doi:10.1038/s41586-019-1034-5.
   PubMed Web of Science ®Google Scholar
• Killin, L.O.J., et al., 2016. Environmental risk factors for dementia: a systematic review. BMC geriatrics, 16 (1), 175. doi:10.1186/s12877-016-0342-y.
   PubMedGoogle Scholar
• Kim, K.-H., Kabir, E., and Kabir, S., 2015. A review on the human health impact of airborne particulate matter. Environment International, 74, 136–143. doi:10.1016/j.envint.2014.10.005
   PubMed Web of Science ®Google Scholar
• Kim, E.J., Kim, J., and Kim, H., 2020. Neighborhood walkability and active transportation: a correlation study in leisure and shopping purposes. International journal of environmental research and public health, 17 (7), 2178. [Internet]: doi:10.3390/ijerph17072178.
   PubMed Web of Science ®Google Scholar
• Knapskog, M., et al., 2019. Exploring ways of measuring walkability. Transportation research procedia, 41, 264–282. doi:10.1016/j.trpro.2019.09.047.
   Google Scholar
• Kular, L. and Jagodic, M., 2020. Epigenetic insights into multiple sclerosis disease progression. Journal of internal medicine, 288 (1), 82–102. doi:10.1111/joim.13045.
   PubMed Web of Science ®Google Scholar
• Lafaille-Magnan, M.E., et al., 2017. Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology, 89 (4), 327–335. doi:10.1212/WNL.0000000000004159.
   PubMed Web of Science ®Google Scholar
• Lahiri, D.K. and Maloney, B., 2010. The “LEARn” (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer’s disease, and proposes remedial steps. Experimental gerontology, 45 (4), 291–296. doi:10.1016/j.exger.2010.01.001.
   PubMed Web of Science ®Google Scholar
• Lahiri, D.K., Maloney, B., and Zawia, N.H., 2009. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Molecular Psychiatry, 14 (11), 992–1003. doi:10.1038/mp.2009.82.
   PubMed Web of Science ®Google Scholar
• Landgrave-Gómez, J., Mercado-Gómez, O., and Guevara-Guzmán, R., 2015. Epigenetic mechanisms in neurological and neurodegenerative diseases. Frontiers in cellular neuroscience, 9, 58. doi:10.3389/fncel.2015.00058
   PubMed Web of Science ®Google Scholar
• Le, T.N., et al., 2017. Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. Journal of otolaryngology-head & neck surgery, 46 (1), 41. doi:10.1186/s40463-017-0219-x.
   Google Scholar
• Lee, J., et al., 2023. Particulate matter exposure and neurodegenerative diseases: a comprehensive update on toxicity and mechanisms. Ecotoxicology and environmental safety, 266, 115565. doi:10.1016/j.ecoenv.2023.115565.
   PubMed Web of Science ®Google Scholar
• Lee, M.K., et al., 2019. Genome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults. Clinical epigenetics, 11 (1), 37. doi:10.1186/s13148-019-0635-z.
   PubMed Web of Science ®Google Scholar
• Levine, M.E., et al., 2015. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning. Aging (Albany NY), 7 (12), 1198–1211. doi:10.18632/aging.100864.
   PubMedGoogle Scholar
• Levine, M.E., et al., 2018. An epigenetic biomarker of aging for lifespan and healthspan. Aging (Albany NY), 10 (4), 573–591. doi:10.18632/aging.101414.
   PubMedGoogle Scholar
• Li, B., et al., 2021. Developmental angiogenesis requires the mitochondrial phenylalanyl-tRNA synthetase. Frontiers in cardiovascular medicine, 8, 724846. doi:10.3389/fcvm.2021.724846.
   PubMed Web of Science ®Google Scholar
• Li, J., et al., 2023. Landscape fire smoke enhances the association between fine particulate matter exposure and acute respiratory infection among children under 5 years of age: findings of a case-crossover study for 48 low- and middle-income countries. Environment international, 171, 107665. doi:10.1016/j.envint.2022.107665.
   PubMed Web of Science ®Google Scholar
• Li, A., Koch, Z., and Ideker, T., 2022. Epigenetic aging: biological age prediction and informing a mechanistic theory of aging. Journal of internal medicine, 292 (5), 733–744. doi:10.1111/joim.13533.
   PubMed Web of Science ®Google Scholar
• Lin, F.C., et al., 2022. Air pollution is associated with cognitive deterioration of Alzheimer’s disease. Gerontology, 68 (1), 53–61. doi:10.1159/000515162.
   PubMed Web of Science ®Google Scholar
• Li, Q.S., Sun, Y., and Wang, T., 2020. Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regions. Clinical epigenetics, 12 (1), 149. doi:10.1186/s13148-020-00944-z.
   PubMed Web of Science ®Google Scholar
• Liu, C.C., et al., 2019. Association of environmental features and the risk of Alzheimer’s dementia in older adults: a nationwide longitudinal case-control study. International journal of environmental research and public health, 16 (16), 2828. doi:10.3390/ijerph16162828.
   PubMed Web of Science ®Google Scholar
• Liu, J., et al., 2017. Assessment of relationship on excess arsenic intake from drinking water and cognitive impairment in adults and elders in arsenicosis areas. International journal of hygiene and environmental health, 220 (2 Pt B), 424–430. doi:10.1016/j.ijheh.2016.12.004.
   PubMed Web of Science ®Google Scholar
• Liu, R.M., 2022. Aging, cellular senescence, and Alzheimer’s disease. International journal of molecular sciences, 23 (4), 1989. doi:10.3390/ijms23041989.
   PubMed Web of Science ®Google Scholar
• Liu, Z., et al., 2020. Underlying features of epigenetic aging clocks in vivo and in vitro. Aging cell, 19 (10), e13229. doi:10.1111/acel.13229.
   PubMed Web of Science ®Google Scholar
• Livingston, G., et al., 2020. Dementia prevention, intervention, and care: 2020 report of the lancet commission. The lancet, 396 (10248), 413–446. doi:10.1016/S0140-6736(20)30367-6.
   PubMed Web of Science ®Google Scholar
• Lu, A.T., et al., 2019. DNA methylation GrimAge strongly predicts lifespan and healthspan. Aging (Albany NY), 11 (2), 303–327. doi:10.18632/aging.101684.
   PubMedGoogle Scholar
• Lu, A.T., et al., 2023. Universal DNA methylation age across mammalian tissues. Nature aging, 3 (9), 1144–1166. doi:10.1038/s43587-023-00462-6.
   PubMedGoogle Scholar
• Lupolt, S.N., et al., 2022. Key considerations for assessing soil ingestion exposures among agricultural workers. Journal of exposure science & environmental epidemiology, 32 (3), 481–492. doi:10.1038/s41370-021-00339-z.
   PubMed Web of Science ®Google Scholar
• Maas, J., et al., 2009. Social contacts as a possible mechanism behind the relation between green space and health. Health & place, 15 (2), 586–595. doi:10.1016/j.healthplace.2008.09.006.
   PubMed Web of Science ®Google Scholar
• Maasar, M.F., et al., 2021. The comparative methylome and transcriptome after change of direction compared to straight line running exercise in human skeletal muscle. Frontiers in physiology, 12, 619447. doi:10.3389/fphys.2021.619447.
   PubMed Web of Science ®Google Scholar
• Maher, B.A., et al., 2016. Magnetite pollution nanoparticles in the human brain. Proceedings of the national academy of sciences, 113 (39), 10797–10801. doi:10.1073/pnas.1605941113.
   PubMed Web of Science ®Google Scholar
• Maitre, L., et al., 2022. Multi-omics signatures of the human early life exposome. Nature communications, 13 (1), 7024. doi:10.1038/s41467-022-34422-2.
   PubMed Web of Science ®Google Scholar
• Marin, C., et al., 2018. Olfactory dysfunction in neurodegenerative diseases. Current allergy and asthma reports, 18 (8), 42. doi:10.1007/s11882-018-0796-4.
   PubMed Web of Science ®Google Scholar
• Marini, M., et al., 2021. Daily intake of heavy metals and minerals in food – a case study of four Danish dietary profiles. Journal of cleaner production, 280, 124279. doi:10.1016/j.jclepro.2020.124279.
   Web of Science ®Google Scholar
• Mazzoleni, E., et al., 2023. Outdoor artificial light at night and risk of early-onset dementia: a case-control study in the Modena population, Northern Italy. Heliyon, 9 (7), e17837. doi:10.1016/j.heliyon.2023.e17837.
   PubMed Web of Science ®Google Scholar
• McCrory, C., et al., 2021. GrimAge outperforms other epigenetic clocks in the prediction of age-related clinical phenotypes and all-cause mortality. Journals of gerontology: series A, 76 (5), 741–749. doi:10.1093/gerona/glaa286.
   PubMed Web of Science ®Google Scholar
• McGowan, P.O. and Roth, T.L., 2015. Epigenetic pathways through which experiences become linked with biology. Development & psychopathology, 27 (2), 637–648. doi:10.1017/S0954579415000206.
   PubMed Web of Science ®Google Scholar
• Meng, L., et al., 2022. Chronic noise exposure and risk of dementia: a systematic review and dose-response meta-analysis. Frontiers in public health, 10, 832881. doi:10.3389/fpubh.2022.832881.
   PubMed Web of Science ®Google Scholar
• Meng, Y., Kelly, F.J., and Wright, S.L., 2020. Advances and challenges of microplastic pollution in freshwater ecosystems: a UK perspective. Environmental pollution, 256, 113445. doi:10.1016/j.envpol.2019.113445
   PubMed Web of Science ®Google Scholar
• Mielke, M.M., Vemuri, P., and Rocca, W.A., 2014. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clinical epidemiology, 6, 37–48. doi:10.2147/CLEP.S37929
   PubMed Web of Science ®Google Scholar
• Millan, M.J., 2014. The epigenetic dimension of Alzheimer’s disease: causal, consequence, or curiosity? Dialogues in clinical neuroscience, 16 (3), 373–393. doi:10.31887/DCNS.2014.16.3/mmillan.
   PubMed Web of Science ®Google Scholar
• Millán-Zambrano, G., et al., 2022. Histone post-translational modifications — cause and consequence of genome function. Nature reviews genetics, 23 (9), 563–580. doi:10.1038/s41576-022-00468-7.
   PubMed Web of Science ®Google Scholar
• Morgensztern, D. et al., 2018. Mutational events in lung cancer: present and developing technologies. In: H.I. Pass, D. Ball, and G.V. Scagliotti, eds. IASLC thoracic oncology 2nd ed. Philadelphia: Elsevier, 95–103.e2.
   Google Scholar
• Morley, J.F., et al., 2018. Optimizing olfactory testing for the diagnosis of Parkinson’s disease: item analysis of the university of Pennsylvania smell identification test. Npj Parkinson’s Disease, 4 (1), 2. doi:10.1038/s41531-017-0039-8.
   PubMedGoogle Scholar
• Mostafavi, N., et al., 2018. Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: a panel study in four European countries. Environment international, 120, 11–21. doi:10.1016/j.envint.2018.07.026.
   PubMed Web of Science ®Google Scholar
• Mueller, B., Figueroa, A., and Robinson-Papp, J., 2022. Structural and functional connections between the autonomic nervous system, hypothalamic–pituitary–adrenal axis, and the immune system: a context and time dependent stress response network. Neurological sciences, 43 (2), 951–960. doi:10.1007/s10072-021-05810-1.
   PubMed Web of Science ®Google Scholar
• Müller, A., et al., 2020. The pollution conveyed by urban runoff: a review of sources. Science of the total environment, 709, 136125. doi:10.1016/j.scitotenv.2019.136125
   PubMed Web of Science ®Google Scholar
• Münzel, T., et al., 2022. Soil and water pollution and human health: what should cardiologists worry about? Cardiovascular research, 119 (2), 440–449. doi:10.1093/cvr/cvac082.
   Web of Science ®Google Scholar
• Murata, H., Barnhill, L.M., and Bronstein, J.M., 2022. Air pollution and the risk of Parkinson’s disease: a review. Movement disorders: official journal of the movement disorder society, 37 (5), 894–904. doi:10.1002/mds.28922.
   PubMed Web of Science ®Google Scholar
• Nichols, E., 2022. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet public health, 7 (2), e105–e125. doi:10.1016/S2468-2667(21)00249-8.
   PubMed Web of Science ®Google Scholar
• Noroozi, R., et al., 2021. DNA methylation-based age clocks: from age prediction to age reversion. Aging research reviews, 68, 101314. doi:10.1016/j.arr.2021.101314.
   PubMed Web of Science ®Google Scholar
• Nous, A., Engelborghs, S., and Smolders, I., 2021. Melatonin levels in the Alzheimer’s disease continuum: a systematic review. Alzheimer’s research & therapy, 13 (1), 52. doi:10.1186/s13195-021-00788-6.
   PubMed Web of Science ®Google Scholar
• Oppenheim, H.A., et al., 2013. Exposure to vehicle emissions results in altered blood brain barrier permeability and expression of matrix metalloproteinases and tight junction proteins in mice. Particle and fibre toxicology, 10 (1), 62. doi:10.1186/1743-8977-10-62.
   PubMedGoogle Scholar
• Pan, X., et al., 2022a. Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS. BMC Geriatrics, 22 (1). doi:10.1186/s12877-022-03375-y.
   Web of Science ®Google Scholar
• Pan, X., et al., 2022b. Associations among drinking water quality, dyslipidemia, and cognitive function for older adults in China: evidence from CHARLS. BMC geriatrics, 22 (1), 683. doi:10.1186/s12877-022-03375-y.
   PubMed Web of Science ®Google Scholar
• Pandics, T., et al., 2023. Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures. GeroScience, 45 (6), 3381–3408. doi:10.1007/s11357-023-00913-3.
   PubMed Web of Science ®Google Scholar
• Panes, J.D., et al., 2022. Deciphering the role of PGC-1α in neurological disorders: from mitochondrial dysfunction to synaptic failure. Neural regeneration research, 17 (2), 237–245. doi:10.4103/1673-5374.317957.
   PubMed Web of Science ®Google Scholar
• Pankhurst, Q., et al., 2008. Increased levels of magnetic iron compounds in Alzheimer’s disease. Journal of Alzheimer’s disease: JAD, 13 (1), 49–52. doi:10.3233/JAD-2008-13105.
   PubMed Web of Science ®Google Scholar
• Panni, S., et al., 2020. Non-coding RNA regulatory networks. Biochimica et biophysica acta (BBA)-Gene regulatory mechanisms, 1863 (6), 194417. doi:10.1016/j.bbagrm.2019.194417.
   PubMed Web of Science ®Google Scholar
• Parade, S.H., et al., 2017. Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers. Development & psychopathology, 29 (5), 1619–1626. doi:10.1017/S0954579417001274.
   PubMed Web of Science ®Google Scholar
• Patel, P.C., 2019. Light pollution and insufficient sleep: evidence from the United States. American journal of human biology, 31 (6), e23300. doi:10.1002/ajhb.23300.
   PubMed Web of Science ®Google Scholar
• Paul, D.S. and Beck, S., 2014. Advances in epigenome-wide association studies for common diseases. Trends in molecular medicine, 20 (10), 541–543. doi:10.1016/j.molmed.2014.07.002.
   PubMed Web of Science ®Google Scholar
• Peters, R., et al., 2019. Air pollution and dementia: a systematic review. Journal of Alzheimer’s disease: JAD, 70 (s1), S145–s63. doi:10.3233/JAD-180631.
   PubMedGoogle Scholar
• Pierce, B.L. and Burgess, S., 2013. Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators. American journal of epidemiology, 178 (7), 1177–1184. doi:10.1093/aje/kwt084.
   PubMed Web of Science ®Google Scholar
• Pirooznia, S.K., et al., 2012. Epigenetic regulation of axonal growth of drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. Genetics, 192 (4), 1327–1345. doi:10.1534/genetics.112.144667.
   PubMed Web of Science ®Google Scholar
• Plaza-Diaz, J., et al., 2022. Impact of physical activity and exercise on the epigenome in skeletal muscle and effects on systemic metabolism. Biomedicines, 10 (1), 126. doi:10.3390/biomedicines10010126.
   PubMed Web of Science ®Google Scholar
• Poprac, P., et al., 2017. Targeting free radicals in oxidative stress-related human diseases. Trends in pharmacological sciences, 38 (7), 592–607. doi:10.1016/j.tips.2017.04.005.
   PubMed Web of Science ®Google Scholar
• Rakyan, V.K., et al., 2011. Epigenome-wide association studies for common human diseases. Nature reviews genetics, 12 (8), 529–541. doi:10.1038/nrg3000.
   PubMed Web of Science ®Google Scholar
• Rao, P., Belanger, M.J., and Robbins, J.M., 2022. Exercise, physical activity, and cardiometabolic health: insights into the prevention and treatment of cardiometabolic diseases. Cardiology in review, 30 (4), 167–178. doi:10.1097/CRD.0000000000000416.
   PubMed Web of Science ®Google Scholar
• Rasmussen, M., Zierath, J.R., and Barrès, R., 2014. Dynamic epigenetic responses to muscle contraction. Drug discovery today, 19 (7), 1010–1014. doi:10.1016/j.drudis.2014.03.003.
   PubMed Web of Science ®Google Scholar
• Relton, C. and Smith, G., 2015. Mendelian randomization: applications and limitations in epigenetic studies. Epigenomics, 7 (8), 1239–1243. doi:10.2217/epi.15.88.
   PubMed Web of Science ®Google Scholar
• Rey, R., et al., 2019. Distinct expression pattern of epigenetic machinery genes in blood leucocytes and brain cortex of depressive patients. Molecular neurobiology, 56 (7), 4697–4707. doi:10.1007/s12035-018-1406-0.
   PubMed Web of Science ®Google Scholar
• Richardson, E.A., et al., 2013. Role of physical activity in the relationship between urban green space and health. Public health, 127 (4), 318–324. doi:10.1016/j.puhe.2013.01.004.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Loureiro, L., et al., 2022. Long-term exposure to residential greenness and neurodegenerative disease mortality among older adults: a 13-year follow-up cohort study. Environmental health, 21 (1). doi:10.1186/s12940-022-00863-x.
   PubMed Web of Science ®Google Scholar
• Roe, J.J., et al., 2013. Green space and stress: evidence from cortisol measures in deprived urban communities. International journal of environmental research and public health, 10 (9), 4086–4103. Internet. doi:10.3390/ijerph10094086.
   PubMed Web of Science ®Google Scholar
• Ryu, H.W., et al., 2015. Influence of toxicologically relevant metals on human epigenetic regulation. Toxicological research, 31 (1), 1–9. doi:10.5487/TR.2015.31.1.001.
   PubMedGoogle Scholar
• Ryu, Y.S., et al., 2019. Particulate matter-induced senescence of skin keratinocytes involves oxidative stress-dependent epigenetic modifications. Experimental & molecular medicine, 51 (9), 1–14. doi:10.1038/s12276-019-0305-4.
   Google Scholar
• Schirmer, L., et al., 2019. Neuronal vulnerability and multilineage diversity in multiple sclerosis. Nature, 573 (7772), 75–82. doi:10.1038/s41586-019-1404-z.
   PubMed Web of Science ®Google Scholar
• Scorza, F. and Fortunato, G., 2021. Cyclable cities: building feasible scenario through urban space morphology assessment. Journal of urban planning and development, 147 (4). doi:10.1061/(ASCE)UP.1943-5444.0000713.
   Web of Science ®Google Scholar
• Sharma, V.K., Mehta, V., and Singh, T.G., 2020. Alzheimer’s disorder: epigenetic connection and associated risk factors. Current neuropharmacology, 18 (8), 740–753. doi:10.2174/1570159X18666200128125641.
   PubMed Web of Science ®Google Scholar
• Shen, X.L., et al., 2014. Positive relationship between mortality from Alzheimer’s disease and soil metal concentration in mainland China. Journal of Alzheimer’s disease: JAD, 42 (3), 893–900. doi:10.3233/JAD-140153.
   PubMed Web of Science ®Google Scholar
• Shireby, G.L., et al., 2020. Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex. Brain A journal of neurology, 143 (12), 3763–3775. doi:10.1093/brain/awaa334.
   PubMedGoogle Scholar
• Shukla, M., et al., 2017. Mechanisms of melatonin in alleviating Alzheimer’s disease. Current neuropharmacology, 15 (7), 1010–1031. doi:10.2174/1570159X15666170313123454.
   PubMed Web of Science ®Google Scholar
• Skinner, M.K., 2011. Role of epigenetics in developmental biology and transgenerational inheritance. Birth defects research Part C, embryo today: Reviews, 93 (1), 51–55. doi:10.1002/bdrc.20199.
   PubMedGoogle Scholar
• Slawsky, E.D., et al., 2022. Neighborhood greenspace exposure as a protective factor in dementia risk among U.S. adults 75 years or older: a cohort study. Environmental health: a global access science source, 21 (1), (no pagination). doi:10.1186/s12940-022-00830-6.
   PubMed Web of Science ®Google Scholar
• Smith, R.G., et al., 2021. A meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights novel differentially methylated loci across cortex. Nature Communications, 12 (1), 3517. doi:10.1038/s41467-021-23243-4.
   PubMed Web of Science ®Google Scholar
• Smith, G.D. and Ebrahim, S., 2003. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease? International journal of epidemiology, 32 (1), 1–22. doi:10.1093/ije/dyg070.
   PubMed Web of Science ®Google Scholar
• Stefanova, N.A., et al., 2015. Melatonin attenuates impairments of structural hippocampal neuroplasticity in OXYS rats during active progression of Alzheimer’s disease-like pathology. Journal of pineal research, 59 (2), 163–177. doi:10.1111/jpi.12248.
   PubMed Web of Science ®Google Scholar
• Su, D., et al., 2018. Chronic noise exposure exacerbates AD-like neuropathology in SAMP8 mice in relation to wnt signaling in the PFC and hippocampus. Scientific reports, 8 (1), 14622. doi:10.1038/s41598-018-32948-4.
   PubMedGoogle Scholar
• Sumien, N., et al., 2021. Neurodegenerative disease: roles for sex, hormones, and oxidative stress. Endocrinology, 162 (11). doi:10.1210/endocr/bqab185.
   PubMed Web of Science ®Google Scholar
• Suresh, S., Singh, S.A., and Vellapandian, C., 2022. Bisphenol a exposure links to exacerbation of memory and cognitive impairment: a systematic review of the literature. Neuroscience & biobehavioral reviews, 143, 104939. doi:10.1016/j.neubiorev.2022.104939
   PubMed Web of Science ®Google Scholar
• Światowy, W.J., et al., 2021. Physical activity and DNA methylation in humans. International journal of molecular sciences, 22 (23), 12989. doi:10.3390/ijms222312989.
   PubMed Web of Science ®Google Scholar
• Sylvers, D.L., et al., 2022. Walkable neighborhoods and cognition: implications for the design of health promoting communities. Journal of aging and health, 34 (6–8), 893–904. doi:10.1177/08982643221075509.
   PubMed Web of Science ®Google Scholar
• Tai, X.Y., et al., 2022. Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet healthy longevity, 3 (6), e428–e36. doi:10.1016/S2666-7568(22)00117-9.
   PubMedGoogle Scholar
• Takasugi, T., et al., 2021. Community-level educational attainment and dementia: a 6-year longitudinal multilevel study in Japan. BMC Geriatrics, 21 (1), 661. doi:10.1186/s12877-021-02615-x.
   PubMed Web of Science ®Google Scholar
• Takiguchi, M., et al., 2003. Effects of cadmium on DNA-(cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Experimental cell research, 286 (2), 355–365. doi:10.1016/S0014-4827(03)00062-4.
   PubMed Web of Science ®Google Scholar
• Tang, B.L., 2020. Neuropathological mechanisms associated with pesticides in Alzheimer’s disease. Toxics, 8 (2), 21. doi:10.3390/toxics8020021.
   PubMed Web of Science ®Google Scholar
• Tang, X., et al., 2022. Epigenetic clock acceleration is linked to age at onset of Parkinson’s disease. Movement disorders: official journal of the movement disorder society, 37 (9), 1831–1840. doi:10.1002/mds.29157.
   PubMed Web of Science ®Google Scholar
• Terada, T., et al., 2020. In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease. Neurology, 94 (15), e1592–e604. doi:10.1212/WNL.0000000000009249.
   PubMed Web of Science ®Google Scholar
• Thanassoulis, G. and O’Donnell, C.J., 2009. Mendelian randomization: nature’s randomized trial in the post-genome era. Jama, 3012009 (22), 2386–2388. doi:10.1001/jama.2009.812.
   Google Scholar
• Thompson, R.C., et al., 2009. Plastics, the environment and human health: current consensus and future trends. Philosophical transactions of the royal society B: Biological sciences, 364 (1526), 2153–2166. doi:10.1098/rstb.2009.0053.
   PubMed Web of Science ®Google Scholar
• Timmermans, E.J., et al., 2023. Neighbourhood walkability in relation to cognitive functioning in patients with disorders along the heart-brain axis. Health & place, 79, 102956. doi:10.1016/j.healthplace.2022.102956.
   PubMed Web of Science ®Google Scholar
• Umberson, D. and Karas Montez, J., 2010. Social relationships and health: a flashpoint for health policy. Journal of health and social behavior, 51 (1_suppl), S54–S66. doi:10.1177/0022146510383501.
   PubMed Web of Science ®Google Scholar
• United Nations Population Division, 2019. World urbanization prospects: 2018 revision. doi:10.18356/b9e995fe-en.
   Google Scholar
• Valavanidis, A., Fiotakis, K., and Vlachogianni, T., 2008. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms. Journal of environmental science and health, part C, 26 (4), 339–362. doi:10.1080/10590500802494538.
   Web of Science ®Google Scholar
• Villafuerte, G., et al., 2015. Sleep deprivation and oxidative stress in animal models: a systematic review. Oxidative medicine and cellular longevity, 2015, 234952. doi:10.1155/2015/234952
   PubMedGoogle Scholar
• Walker, V.M., et al., 2019. Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes. Wellcome open research, 4, 113. doi:10.12688/wellcomeopenres.15334.1.
   PubMedGoogle Scholar
• Walker, W.H., et al., 2020. Circadian rhythm disruption and mental health. Translational psychiatry, 10 (1), 28. doi:10.1038/s41398-020-0694-0.
   PubMed Web of Science ®Google Scholar
• Wang, C., et al., 2020. Associations of annual ambient PM(2.5) components with DNAm PhenoAge acceleration in elderly men: the normative aging study. Environmental pollution, 258, 113690. doi:10.1016/j.envpol.2019.113690
   PubMed Web of Science ®Google Scholar
• Wang, K., et al., 2022. Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal transduction and targeted therapy, 7 (1), 374. doi:10.1038/s41392-022-01211-8.
   PubMed Web of Science ®Google Scholar
• Wang, R.Z., et al., 2021. Genetically determined low income modifies Alzheimer’s disease risk. Annals of translational medicine, 9 (15), 1222. doi:10.21037/atm-21-344.
   PubMed Web of Science ®Google Scholar
• Wang, Y., et al., 2020. Independent effect of main components in particulate matter on DNA methylation and DNA methyltransferase: a molecular epidemiology study. Environment international, 134, 105296. doi:10.1016/j.envint.2019.105296.
   PubMed Web of Science ®Google Scholar
• Wang, Z., et al., 2016. Chronic exposure to aluminum and risk of Alzheimer’s disease: a meta-analysis. Neuroscience letters, 610, 200–206. doi:10.1016/j.neulet.2015.11.014.
   PubMed Web of Science ®Google Scholar
• Warraich, U.E., Hussain, F., and Kayani, H.U.R., 2020. Aging - oxidative stress, antioxidants and computational modeling. Heliyon, 6 (5), e04107. doi:10.1016/j.heliyon.2020.e04107.
   PubMed Web of Science ®Google Scholar
• Wei, J., et al., 2021. DNA methyltransferase 3A is involved in the sustained effects of chronic stress on synaptic functions and behaviors. Cerebral cortex (New York, NY: 1991), 31 (4), 1998–2012. doi:10.1093/cercor/bhaa337.
   PubMed Web of Science ®Google Scholar
• White, A.J., et al., 2019. Air pollution, particulate matter composition and methylation-based biologic age. Environment international, 132, 105071. doi:10.1016/j.envint.2019.105071.
   PubMed Web of Science ®Google Scholar
• White, L., et al., 2020. Dementia is associated with earlier mortality for men and women in the United States. Gerontology and geriatric medicine, 6, 2333721420945922. doi:10.1177/2333721420945922
   Web of Science ®Google Scholar
• White, M.P., et al., 2020. Blue space, health and well-being: a narrative overview and synthesis of potential benefits. Environmental research, 191, 110169. doi:10.1016/j.envres.2020.110169.
   PubMed Web of Science ®Google Scholar
• Wiegand, A., et al., 2021. DNA methylation differences associated with social anxiety disorder and early life adversity. Translational psychiatry, 11 (1), 104. doi:10.1038/s41398-021-01225-w.
   PubMed Web of Science ®Google Scholar
• Williams, M.E., et al., 2023. Higher cortical thickness/volume in Alzheimer’s-related regions: protective factor or risk factor? Neurobiology of aging, 129, 185–194. doi:10.1016/j.neurobiolaging.2023.05.004.
   PubMed Web of Science ®Google Scholar
• Wilson, J. and Xiao, X., 2023. The economic value of health benefits associated with urban park investment. International journal of environmental research and public health, 20 (6), 4815. doi:10.3390/ijerph20064815.
   PubMedGoogle Scholar
• Wittenberg, R., et al., 2020. Projections of care for older people with dementia in England: 2015 to 2040. Age and ageing, 49 (2), 264–269. doi:10.1093/ageing/afz154.
   PubMed Web of Science ®Google Scholar
• Wittfeld, K., et al., 2020. Cardiorespiratory fitness and gray matter volume in the temporal, frontal, and cerebellar regions in the general population. Mayo clinic proceedings, 95 (1), 44–56. doi:10.1016/j.mayocp.2019.05.030.
   PubMed Web of Science ®Google Scholar
• World Health Organisation, 2013. Health effects of particulate matter: policy implications for countries in eastern Europe. Caucasus and central Asia.
   Google Scholar
• World Health Organisation, 2021. Urban health. Available from: https://www.who.int/news-room/fact-sheets/detail/urban-health.
   Google Scholar
• World Health Organisation, 2021. WHO global air quality guidelines: Particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide.
   Google Scholar
• Wu, J., et al., 2022. Air pollution as a risk factor for Cognitive Impairment No Dementia (CIND) and its progression to dementia: a longitudinal study. Environment international, 160, 107067. doi:10.1016/j.envint.2021.107067.
   PubMed Web of Science ®Google Scholar
• Wu, J.W., et al., 2021. Biological age in healthy elderly predicts aging-related diseases including dementia. Scientific reports, 11 (1), 15929. doi:10.1038/s41598-021-95425-5.
   PubMed Web of Science ®Google Scholar
• Wu, Y.T., et al., 2020. Neighbourhood environment and dementia in older people from high-, middle- and low-income countries: results from two population-based cohort studies. Bmc public health, 20 (1). doi:10.1186/s12889-020-09435-5.
   Web of Science ®Google Scholar
• Wu, Z., et al., 2021. Gray matter deterioration pattern during Alzheimer’s disease progression: a regions-of-interest based surface morphometry study. Frontiers in aging neuroscience, 13, 593898. doi:10.3389/fnagi.2021.593898.
   PubMed Web of Science ®Google Scholar
• Wu, H., Eckhardt, C.M., and Baccarelli, A.A., 2023. Molecular mechanisms of environmental exposures and human disease. Nature reviews genetics, 24 (5), 332–344. doi:10.1038/s41576-022-00569-3.
   PubMed Web of Science ®Google Scholar
• Xu, R., et al., 2021. Residential surrounding greenness and DNA methylation: an epigenome-wide association study. Environment international, 154, 106556. doi:10.1016/j.envint.2021.106556.
   PubMed Web of Science ®Google Scholar
• Xu, S., Akioma, M., and Yuan, Z., 2021. Relationship between circadian rhythm and brain cognitive functions. Frontiers of optoelectronics, 14 (3), 278–287. doi:10.1007/s12200-021-1090-y.
   PubMed Web of Science ®Google Scholar
• Yang, N. and Sen, P., 2018. The senescent cell epigenome. Aging (Albany NY), 10 (11), 3590–3609. doi:10.18632/aging.101617.
   PubMedGoogle Scholar
• Yannatos, I. et al., 2022. Contributions of neighborhood social environment and air pollution exposure to black-white disparities in epigenetic aging. PLoS One, 18 (7), e0287112. doi:10.1371/journal.pone.0287112.
   Web of Science ®Google Scholar
• Yu, X., et al., 2020. Exposure to air pollution and cognitive impairment risk: a meta-analysis of longitudinal cohort studies with dose-response analysis. Journal of global health, 10 (1), 010417. doi:10.7189/jogh.10.010417.
   PubMed Web of Science ®Google Scholar
• Zeng, B., Liu, G., and Huang, J., 2022. DNA methylation and histone modification in dental-derived mesenchymal stem cells. Stem cell reviews & reports, 18 (8), 2797–2816. doi:10.1007/s12015-022-10413-0.
   PubMed Web of Science ®Google Scholar
• Zhang, L., et al., 2022a. Targeting epigenetics as a promising therapeutic strategy for treatment of neurodegenerative diseases. Biochemical pharmacology, 206, 115295. doi:10.1016/j.bcp.2022.115295.
   PubMed Web of Science ®Google Scholar
• Zhang, L., et al., 2022b. Green space, air pollution, weather, and cognitive function in middle and old age in China. Frontiers in public health, 10. doi:10.3389/fpubh.2022.871104.
   Web of Science ®Google Scholar
• Zhang, X., et al., 2020. Effects of green space on walking: does size, shape and density matter? Urban studies, 57 (16), 3402–3420. doi:10.1177/0042098020902739.
   Web of Science ®Google Scholar
• Zhao, Y., et al., 2014. Aluminum-induced amyloidogenesis and impairment in the clearance of amyloid peptides from the central nervous system in Alzheimer’s disease. Frontiers in neurology, 5, 167. doi:10.3389/fneur.2014.00167
   PubMed Web of Science ®Google Scholar
• Zheng, J., et al., 2017. Recent developments in Mendelian randomization studies. Current epidemiology reports, 4 (4), 330–345. doi:10.1007/s40471-017-0128-6.
   PubMedGoogle Scholar
• Zhou, A., et al., 2022. Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review. Epigenomics, 14 (18), 1125–1138. doi:10.2217/epi-2022-0209.
   PubMed Web of Science ®Google Scholar
• Zhou, C.C., et al., 2018. Lead exposure induces Alzheimer's disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain. Toxicology letters, 296, 173–183. doi:10.1016/j.toxlet.2018.06.1065.
   PubMed Web of Science ®Google Scholar
• Zhou, X., et al., 2022. Alcohol consumption, DNA methylation and colorectal cancer risk: results from pooled cohort studies and Mendelian randomization analysis. International journal of cancer, 151 (1), 83–94. doi:10.1002/ijc.33945.
   PubMed Web of Science ®Google Scholar
• Zukowska, J., et al., 2022. Which transport policies increase physical activity of the whole of society? A systematic review. Journal of transport & health, 27, 101488. doi:10.1016/j.jth.2022.101488.
   Web of Science ®Google Scholar
• Zuniga-Teran, A.A., et al., 2019. Exploring the influence of neighborhood walkability on the frequency of use of greenspace. Landscape and urban planning, 190, 103609. doi:10.1016/j.landurbplan.2019.103609.
   Web of Science ®Google Scholar