247
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Elevated Serum Vinculin in Patients with HBV/HCV-Associated Liver Cirrhosis and Hepatocellular Carcinoma: A Pilot Study

ORCID Icon, , , , ORCID Icon, & ORCID Icon show all
Pages 23-32 | Received 20 Jan 2023, Accepted 04 Mar 2023, Published online: 19 Mar 2023

References

  • Yu H, Shen Y, Jin J, Zhang Y, Feng T, Liu X. Fluid shear stress regulates HepG2 cell migration though time-dependent integrin signaling cascade. Cell Adh Migr. 2018;12:56–68. doi:10.1080/19336918.2017.1319042
  • Yang JD, Nakamura I, Roberts LR. The tumor microenvironment in hepatocellular carcinoma: current status and therapeutic targets. In: Seminars in Cancer Biology. Elsevier; 2011.
  • Oskarsson T. Extracellular matrix components in breast cancer progression and metastasis. Breast. 2013;22(Suppl 2):S66–72. doi:10.1016/j.breast.2013.07.012
  • Dong Y, Zheng Q, Wang Z, et al. Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis. J Hematol Oncol. 2019;12:112. doi:10.1186/s13045-019-0795-5
  • Levental KR, Yu H, Kass L, et al. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009;139:891–906. doi:10.1016/j.cell.2009.10.027
  • Leight JL, Wozniak MA, Chen S, Lynch ML, Chen CS. Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition. Mol Biol Cell. 2012;23:781–791. doi:10.1091/mbc.e11-06-0537
  • Tilghman RW, Cowan CR, Mih JD, et al. Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One. 2010;5:e12905. doi:10.1371/journal.pone.0012905
  • Tilghman RW, Blais EM, Cowan CR, et al. Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. PLoS One. 2012;7:e37231. doi:10.1371/journal.pone.0037231
  • Kshitiz P, Kim P, Helen W, Engler A, Levchenko A, Kim D. Control of stem cell fate and function by engineering physical microenvironments. Integr Biol UK. 2012;4:1008–1018. doi:10.1039/c2ib20080e
  • Keely PJ. Mechanisms by which the extracellular matrix and integrin signaling act to regulate the switch between tumor suppression and tumor promotion. J Mammary Gland Biol Neoplasia. 2011;16:205–219. doi:10.1007/s10911-011-9226-0
  • Yeung T, Georges PC, Flanagan LA, et al. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton. 2005;60:24–34. doi:10.1002/cm.20041
  • Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology. 2004;127:S35–S50. doi:10.1053/j.gastro.2004.09.014
  • Greten T, Papendorf F, Bleck J, et al. Survival rate in patients with hepatocellular carcinoma: a retrospective analysis of 389 patients. Br J Cancer. 2005;92:1862–1868. doi:10.1038/sj.bjc.6602590
  • Jung KS, Kim SU, Choi GH, et al. Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®). Ann Surg Oncol. 2012;19:4278–4286. doi:10.1245/s10434-012-2422-3
  • Cescon M, Colecchia A, Cucchetti A, et al. Value of transient elastography measured with FibroScan in predicting the outcome of hepatic resection for hepatocellular carcinoma. Ann Surg. 2012;256:706–713. doi:10.1097/SLA.0b013e3182724ce8
  • Omachi T, Ichikawa T, Kimura Y, Ueda K, Kioka N. Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behavior. PLoS One. 2017;12:e0175324. doi:10.1371/journal.pone.0175324
  • Bakolitsa C, Cohen DM, Bankston LA, et al. Structural basis for vinculin activation at sites of cell adhesion. Nature. 2004;430:583–586. doi:10.1038/nature02610
  • Borgon RA, Vonrhein C, Bricogne G, Bois PR, Izard T. Crystal structure of human vinculin. Structure. 2004;12:1189–1197. doi:10.1016/j.str.2004.05.009
  • Johnson RP, Craig SW. Actin activates a cryptic dimerization potential of the vinculin tail domain. J Biol Chem. 2000;275:95–105. doi:10.1074/jbc.275.1.95
  • Shi X, Guo X, Li X, Wang M, Qin R. Loss of Linc01060 induces pancreatic cancer progression through vinculin-mediated focal adhesion turnover. Cancer Lett. 2018;433:76–85. doi:10.1016/j.canlet.2018.06.015
  • Thakur RK, Yadav VK, Kumar A, et al. Non-metastatic 2 (NME2)-mediated suppression of lung cancer metastasis involves transcriptional regulation of key cell adhesion factor vinculin. Nucleic Acids Res. 2014;42:11589–11600. doi:10.1093/nar/gku860
  • Sun Z, Liu F. Association of Nox1 and vinculin with colon cancer progression. Cancer Invest. 2013;31:273–278. doi:10.3109/07357907.2013.789897
  • Liang Q, Han Q, Huang W, et al. HAb18G/CD147 regulates vinculin-mediated focal adhesion and cytoskeleton organization in cultured human hepatocellular carcinoma cells. PLoS One. 2014;9:e102496. doi:10.1371/journal.pone.0102496
  • Xiao W, Zhao S, Shen F, Liang J, Chen J. Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma. Exp Ther Med. 2017;14:2637–2642. doi:10.3892/etm.2017.4818
  • EASL Clinical Practice. Guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.
  • Davis GL, Dempster J, Meler JD, et al. Hepatocellular carcinoma: management of an increasingly common problem. In: Baylor University Medical Center Proceedings. Taylor Francis; 2008.
  • Zhou J, Sun H, Wang Z, et al. Guidelines for the diagnosis and treatment of hepatocellular carcinoma (2019 Edition). Liver Cancer. 2020;9:682–720. doi:10.1159/000509424
  • Yam JWP, Tse EYT, Ng IO-L. Role and significance of focal adhesion proteins in hepatocellular carcinoma. J Gastroenterol Hepatol. 2009;24:520–530.
  • Ishihara S, Haga H. Matrix stiffness contributes to cancer progression by regulating transcription factors. Cancers. 2022;14:1049. doi:10.3390/cancers14041049
  • Mueller S, Sandrin L. Liver stiffness: a novel parameter for the diagnosis of liver disease. Hepat Med. 2010;2:49–67. doi:10.2147/HMER.S7394
  • Schrader J, Gordon-Walker TT, Aucott RL, et al. Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology. 2011;53:1192–1205. doi:10.1002/hep.24108
  • Jiang Y, Zhang H, Wang J, Liu Y, Luo T, Hua H. Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. J Hematol Oncol. 2022;15:34. doi:10.1186/s13045-022-01252-0
  • Thievessen I, Fakhri N, Steinwachs J, et al. Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J. 2015;29:4555. doi:10.1096/fj.14-268235
  • Shen K, Kenche H, Zhao H, Li J, Stone J. The role of extracellular matrix stiffness in regulating cytoskeletal remodeling via vinculin in synthetic smooth muscle cells. Biochem Biophys Res Commun. 2019;508:302–307. doi:10.1016/j.bbrc.2018.11.142
  • Petit V, Thiery J-P. Focal adhesions: structure and dynamics. Biol Cell. 2000;92:477–494. doi:10.1016/S0248-4900(00)01101-1
  • Zaidel-Bar R, Itzkovitz S, Ma’ayan A, Iyengar R, Geiger B. Functional atlas of the integrin adhesome. Nat Cell Biol. 2007;9:858–867. doi:10.1038/ncb0807-858
  • Wen -K-K, Rubenstein PA, DeMali KA. Vinculin nucleates actin polymerization and modifies actin filament structure. J Biol Chem. 2009;284:30463–30473. doi:10.1074/jbc.M109.021295
  • Xu W, Baribault H, Adamson ED. Vinculin knockout results in heart and brain defects during embryonic development. Development. 1998;125:327–337. doi:10.1242/dev.125.2.327
  • Thievessen I, Thompson PM, Berlemont S, et al. Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol. 2013;202:163–177. doi:10.1083/jcb.201303129
  • Mierke CT, Kollmannsberger P, Zitterbart DP, et al. Vinculin facilitates cell invasion into three-dimensional collagen matrices. J Biol Chem. 2010;285:13121–13130. doi:10.1074/jbc.M109.087171
  • Rodriguez Fernandez J, Geiger B, Salomon D, Sabanay I, Zöller M, Ben-Ze’ev A. Suppression of tumorigenicity in transformed cells after transfection with vinculin cDNA. J Cell Biol. 1992;119:427–438. doi:10.1083/jcb.119.2.427
  • Peng X, Nelson ES, Maiers JL, DeMali KA. New insights into vinculin function and regulation. Int Rev Cell Mol Biol. 2011;287:191–231.
  • Rubashkin MG, Cassereau L, Bainer R, et al. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3, 4, 5)-triphosphate. Cancer Res. 2014;74:4597–4611. doi:10.1158/0008-5472.CAN-13-3698
  • Koch TM, Münster S, Bonakdar N, Butler JP, Fabry B. 3D traction forces in cancer cell invasion. PLoS One. 2012;7:e33476. doi:10.1371/journal.pone.0033476