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Biologics: Targets and Therapy Volume 17, 2023 - Issue
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ORIGINAL RESEARCH

The Effect of Two Years of Secukinumab Treatment on Bone Metabolism in Patients with Radiographic Axial Spondyloarthritis: Results from Daily Clinical Practice

Mark Siderius1 Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-1236-4341View further author information
ORCID Icon,
Stan C Kieskamp1 Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsView further author information
,
Freke Wink2 Rheumatology, Medical Centre Leeuwarden, Groningen, the NetherlandsView further author information
,
Frans GM Kroese1 Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsView further author information
,
Suzanne Arends1 Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsORCID Iconhttps://orcid.org/0000-0002-4422-7640View further author information
ORCID Icon &
Anneke Spoorenberg1 Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, the NetherlandsCorrespondence[email protected]
View further author information
Pages 161-166 | Received 05 Sep 2023, Accepted 27 Oct 2023, Published online: 13 Dec 2023

References

  • Ramiro S, Nikiphorou E, Sepriano A, et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 update. Ann Rheum Dis. 2023;82(1):19–34. doi:10.1136/ard-2022-223296
  • Arends S, Spoorenberg A, Houtman PM, et al. The effect of three years of TNF-alpha blocking therapy on markers of bone turnover and their predictive value for treatment discontinuation in patients with ankylosing spondylitis: a prospective longitudinal observational cohort study. Arthritis Res Ther. 2012;14(2):R98. doi:10.1186/ar3823
  • Siderius M, Arends S, Wink F, Kroese FGM, Spoorenberg A. Stable bone turnover markers corrected for age and gender during the first year of secukinumab treatment in radiographic axial spondyloarthritis. Clin Exp Rheumatol. 2023. doi:10.55563/clinexprheumatol/i2fnno
  • Arends S, Brouwer E, van der Veer E, et al. Baseline predictors of response and discontinuation of tumor necrosis factor-alpha blocking therapy in ankylosing spondylitis: a prospective longitudinal observational cohort study. Arthritis Res Ther. 2011;13(3):R94. doi:10.1186/ar3369
  • Creemers MCW, Franssen MJAM, Van’t Hof MA, Gribnau FWJ, van de Putte LBA, van Riel PLCM. Assessment of outcome in ankylosing spondylitis: an extended radiographic scoring system. Ann Rheum Dis. 2005;64(1):127–129. doi:10.1136/ard.2004.020503
  • de Vlam K, Mielants H, Veys EM. Involvement of the zygapophyseal joint in ankylosing spondylitis: relation to the bridging syndesmophyte. J Rheumatol. 1999;26(8):1738–1745.
  • Genant HK, Wu CY, van Kuijk C, Nevitt MC. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993;8(9):1137–1148. doi:10.1002/jbmr.5650080915
  • Braun J, Buehring B, Baraliakos X, et al. Effects of secukinumab on bone mineral density and bone turnover biomarkers in patients with ankylosing spondylitis: 2-year data from a Phase 3 study, MEASURE 1. BMC Musculoskelet Disord. 2021;22(1):1037. doi:10.1186/s12891-021-04930-1
  • Baraliakos X, Van der Heijde D, Machado P, et al. Pos1115 effect of secukinumab versus adalimumab biosimilar on radiographic progression in patients with radiographic axial spondyloarthritis: subgroup analyses by baseline syndesmophytes and C-reactive protein status. In: Scientific Abstracts. BMJ Publishing Group Ltd and European League Against Rheumatism; 2023:882.1–883. doi:10.1136/annrheumdis-2023-eular.1274
  • Arends S, Spoorenberg A, Brouwer E, van der Veer E. Clinical studies on bone-related outcome and the effect of TNF-α blocking therapy in ankylosing spondylitis. Curr Opin Rheumatol. 2014;26(3):259–268. doi:10.1097/BOR.0000000000000053
  • Rai AD, Sherpa ML, Singh A, Thejaswi SG, Bhutia RD. Bone alkaline phosphatase and urine hydroxyproline assay in pre and postmenopausal women in the state of Sikkim and its correlation with bone mineral density. J Midlife Health. 2021;12(4):304–309. doi:10.4103/jmh.jmh_73_21
  • Shah M, Maroof A, Gikas P, et al. Dual neutralisation of IL-17F and IL-17A with bimekizumab blocks inflammation-driven osteogenic differentiation of human periosteal cells. RMD Open. 2020;6(2):e001306. doi:10.1136/rmdopen-2020-001306

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