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ORIGINAL RESEARCH

Hypoxia Inducible Factor-1α Through ROS/NLRP3 Pathway Regulates the Mechanism of Acute Ischemic Stroke Microglia Scorching Mechanism

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Pages 167-180 | Received 30 Oct 2023, Accepted 13 Dec 2023, Published online: 18 Dec 2023

References

  • GBD 2016 Stroke Collaborators. Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439–458. PMID: 30871944; PMCID: PMC6494974. doi:10.1016/S1474-4422(19)30034-1
  • Ge J. Internal Medicine. People’s Health Publishing House; 2018.
  • Bok S, Kim YE, Woo YK, et al. Hypoxia-inducible factor-1α regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice. Oncotarget. 2017;8(67):111508–111521. PMID: 29340071; PMCID: PMC5762339. doi:10.18632/oncotarget.22851
  • Sun Y, Chen X, Zhang X, et al. β2-Adrenergic receptor-mediated HIF-1α upregulation mediates blood brain barrier damage in acute cerebral ischemia. Front Mol Neurosci. 2017;10:257. Erratum in: Front Mol Neurosci. 2017 Nov 20;10:392. PMID: 28855859; PMCID: PMC5558520. doi:10.3389/fnmol.2017.00257
  • Xu W, Xu R, Li Z, et al. Hypoxia changes chemotaxis behaviour of mesenchymal stem cells via HIF-1α signalling. J Cell Mol Med. 2019;23(3):1899–1907. PMID: 30628201; PMCID: PMC6378219. doi:10.1111/jcmm.14091
  • Li Y, Dammer EB, Zhang-Brotzge X, et al. Osteopontin is a blood biomarker for microglial activation and brain injury in experimental hypoxic-ischemic encephalopathy. eNeuro. 2017;4(1):ENEURO.0253–16.2016. PMID: 28101531; PMCID: PMC5223053. doi:10.1523/ENEURO.0253-16.2016
  • Ystgaard MB, Scheffler K, Suganthan R, et al. Neuromodulatory effect of NLRP3 and ASC in neonatal hypoxic ischemic encephalopathy. Neonatology. 2019;115(4):355–362. PMID: 30909283. doi:10.1159/000497200
  • Al Mamun A, Yu H, Mirza MA, et al. Myeloid cell IRF4 signaling protects neonatal brains from hypoxic ischemic encephalopathy. Neurochem Int. 2019;127:148–157. PMID: 30586599; PMCID: PMC6579623. doi:10.1016/j.neuint.2018.12.014
  • Ozen I, Ruscher K, Nilsson R, et al. Interleukin-1 beta neutralization attenuates traumatic brain injury-induced microglia activation and neuronal changes in the globus pallidus. Int J Mol Sci. 2020;21(2):387. PMID: 31936248; PMCID: PMC7014296. doi:10.3390/ijms21020387
  • Li Q, Dai Z, Cao Y, et al. Caspase-1 inhibition mediates neuroprotection in experimental stroke by polarizing M2 microglia/macrophage and suppressing NF-κB activation. Biochem Biophys Res Commun. 2019;513(2):479–485. PMID: 30979498. doi:10.1016/j.bbrc.2019.03.202
  • Zhang X, Zhu XL, Ji BY, et al. LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke. J Neuroinflammation. 2019;16(1):75. PMID: 30961627; PMCID: PMC6452518. doi:10.1186/s12974-019-1464-x
  • Chen J, Zhang W, Zhao M, et al. Molecular regulation mechanism of pyroptosis and its research progress in heart failure. J Liaoning Univ Trad Chin Med. 2022;24(2):176–184. doi:10.13194/j.issn.1673-842x.2022.02.039
  • Yu P, Zhang X, Liu N, et al. Pyroptosis: mechanisms and diseases. Signal Transduct Target Ther. 2021;6(1):128. PMID: 33776057; PMCID: PMC8005494. doi:10.1038/s41392-021-00507-5
  • Gou X, Xu D, Li F, et al. Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies. J Physiol Biochem. 2021;77(4):511–529. PMID: 33942252. doi:10.1007/s13105-021-00817-w
  • Qu Z, Zhou J, Zhou Y, et al. Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway. Sci Adv. 2020;6(43):eaba4733. PMID: 33097533; PMCID: PMC7608829. doi:10.1126/sciadv.aba4733
  • Tian X, Li Y, Li H, et al. Effect of Huanglian Wendan Decoction on the classic pathway of scorch death of skeletal Muscle cell in IGT rats. Chin J Exp Form. 2021;27(18):1–8. doi:10.13422/j.cnki.syfjx.20211704
  • Wang K, Rong L, Wei X, et al. The influencing factors and prognosis of negative diffusion weighted magnetic resonance imaging in patients with acute ischemic stroke. The Interventional Neurology Professional Committee of the Chinese Research Hospital Association, the Neurovascular Intervention Collaborative Group of the Neurology Branch of the Chinese Medical Association, the Neurointervention Professional Committee of the Jiangsu Stroke Society, and the Eastern Theater General Hospital (formerly Nanjing General Hospital), The First Affiliated Hospital of University of Science and Technology of China. Proceedings of the 15th International Cerebrovascular Disease Summit Forum, China Interventional Neurology Conference [Publisher unknown]; 2019:165–166.
  • Han Y, Wang S, Huang C, et al. Correlation analysis of serum Lp-PLA2 with HCY, hsCRP, and biochemical markers in patients with acute ischemic stroke. Chin J Emer Med. 2019;28(8):1026–1028.
  • Suzhou, Tian X, Wang Y, et al. Effect of edaravone on the expression of mitogen-activated protein kinase/extracellular regulatory protein kinase signaling pathway proteins in patients with acute ischemic stroke. Chin J Geriatr. 2018;37(12):1372–1375.
  • Zhang D, Li M, Wang Z, et al. Progress in the mechanism of hypoxia-induced factor-1 α mediating neurostem-progenitor cells in an ischemic stroke model. Rehab Theory Pract China. 2017;23(3):319–322.
  • Liu F, Wang G. Related mechanisms and research progress of HIF-1α regulation of glucose metabolism in malignant tumors. Chin Med Innov. 2021;18(27):173–176.
  • Wei Y, Lu B, Jin L, et al. Effects of danquinone on cell proliferation, apoptosis and invasion and HIF-1α expression in HepG 2 under hypoxia. Mod Appl Pharm China. 2022;39(14):1789–1795. doi:10.13748/j.cnki.issn1007-7693.2022.14.001
  • Wang X, Zhao F, Zhang R, et al. Small-molecule inhibitor of anti-tumor hypoxia-inducible factor-1. Chem Prog. 2021;33(12):2259–2269.
  • Milner E, Johnson AW, Nelson JW, et al. HIF-1α mediates isoflurane-induced vascular protection in subarachnoid hemorrhage. Ann Clin Transl Neurol. 2015;2(4):325–337. PMID: 25909079; PMCID: PMC4402079. doi:10.1002/acn3.170
  • Zhao H, Li L, Miao C, et al. Effect of tanshinone A on the expression of HIF-1α and VE GF in the brain tissue of rats with ICH. J Stroke Neurol Dis. 2017;34(2):130–132. doi:10.19845/j.cnki.zfysjjbzz.2017.02.009
  • Du C, Li N, Zhao Y, et al. The relationship between the levels of NT-proBNP, IGF-1, and HIF-1α and the prognosis of patients with cerebral hemorrhage. Lab Med Clin Prac. 2017;14(18):2707–2710.
  • Zheng H, Cathy D, Lou X, et al. Correlation between expression of hypoxia-inducing factor-1 α/vascular endothelial growth factor pathway and intracranial pressure and prognosis in patients with hypertensive cerebral hemorrhage. Chin J Hypertens. 2022;30(3):283–286. doi:10.16439/j.issn.1673-7245.2022.03.014
  • Lu Y. The NLRP-3/Caspase-1/GSDMD Signaling Axis Mediates Pyroptosis in Microglia. Suzhou University; 2020. doi:10.27351/d.cnki.gszhu.2020.003571
  • Luo L, Han Z, Feng R, et al. Microglia in a common signaling pathway for activation in ischemic stroke. J Gannan Med Coll. 2021;41(8):844–850.
  • Qin C, Zhou LQ, Ma XT, et al. Dual functions of microglia in ischemic stroke. Neurosci Bull. 2019;35(5):921–933. PMID: 31062335; PMCID: PMC6754485. doi:10.1007/s12264-019-00388-3
  • Xue Y, Enosi Tuipulotu D, Tan WH, et al. Emerging activators and regulators of inflammasomes and pyroptosis. Trends Immunol. 2019;40(11):1035–1052. PMID: 31662274. doi:10.1016/j.it.2019.09.005
  • Sun R, Peng M, Xu P, et al. Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury. J Neuroinflammation. 2020;17(1):330. PMID: 33153475; PMCID: PMC7643474. doi:10.1186/s12974-020-01988-x
  • Xu P, Zhang X, Liu Q, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019;10(8):555. PMID: 31324751; PMCID: PMC6642102. doi:10.1038/s41419-019-1777-9
  • Sarhan M, Land WG, Tonnus W, et al. Origin and consequences of necroinflammation. Physiol Rev. 2018;98(2):727–780. PMID: 29465288. doi:10.1152/physrev.00041.2016
  • Frank D, Vince JE. Pyroptosis versus necroptosis: similarities, differences, and crosstalk. Cell Death Differ. 2019;26(1):99–114. PMID: 30341423; PMCID: PMC6294779. doi:10.1038/s41418-018-0212-6
  • Sun L, Ma W, Gao W, et al. Propofol directly induces caspase-1-dependent macrophage pyroptosis through the NLRP3-ASC inflammasome. Cell Death Dis. 2019;10(8):542. PMID: 31316052; PMCID: PMC6637184. doi:10.1038/s41419-019-1761-4
  • Sho T, Xu J. Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation. Biotechnol Appl Biochem. 2019;66(1):4–13. PMID: 30315709. doi:10.1002/bab.1700
  • Kesavardhana S, Malireddi RKS, Kanneganti TD. Caspases in cell death, inflammation, and pyroptosis. Annu Rev Immunol. 2020;38:567–595. PMID: 32017655; PMCID: PMC7190443. doi:10.1146/annurev-immunol-073119-095439
  • Jiang Q, Geng X, Warren J, et al. Hypoxia inducible Factor-1α (HIF-1α) mediates NLRP3 inflammasome-dependent-pyroptotic and apoptotic cell death following ischemic stroke. Neuroscience. 2020;448:126–139. PMID: 32976985. doi:10.1016/j.neuroscience.2020.09.036
  • Fu X, Zhao Y. Brain protective effect and mechanism of K~ + ATP channel opening agent nicorodidil in a mouse model of ischemic stroke. Chin J Neuroimmunol Neurol. 2023;30(1):25–29+38.