Potential Effects of Traditional Chinese Medicine in Anti-Aging and Aging-Related Diseases: Current Evidence and Perspectives

References

• World Health Organization. Ageing and health; 2022. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health. Accessed September 1, 2022.
   Google Scholar
• Zhang M. Study on the Medication Rule of Ancient Anti-senile Prescriptions [ PhD Thesis]. China Academy of Chinese Medical Sciences; 2018.
   Google Scholar
• Gómez-Linton DR, Alavez S, Alarcón-Aguilar A, et al. Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging. Biogerontology. 2019;20(5):583–603. doi:10.1007/s10522-019-09817-2
   PubMed Web of Science ®Google Scholar
• Xiao G, Xuan Z, Xiaozhen G, et al. Jiawei Sijunzi decoction delays aging of mouse spleen tissue through mTOR signaling pathway. Acad J Second Mil Med Univ. 2020;41(12):1410–1413. doi:10.16781/j.0258-879x.2020.12.1410
   Google Scholar
• Ying S, Xiao G, Yanqiong Q, et al. Flavored Sijunzi Delays aging of brain tissue of mice via mTOR signaling pathway. Acta Med Univ Sci Technol Huazhong. 2018;47(04):417–420.
   Google Scholar
• Fan Z, Ao X, Jinyue Y, et al. Metabonomics study of Jinkui Shenqi pills on improving the memory ability of D-galactose-induced aging rats. Chin J Pharm Anal. 2020;40(12):2149–2156. doi:10.16155/j.0254-1793.2020.12.07
   Google Scholar
• Yan Z, Changcheng Z, Yuan Y, et al. Protective effects on shenqi pills against injury of tight junction function of sertoli cells in the testis of aging rats and its mechanism. Traditional Chin Drug Res Clin Pharmacol. 2021;32(06):783–790. doi:10.19378/j.issn.1003-9783.2021.06.006
   Google Scholar
• Zhu Y, Han Y, Wang W, et al. Mulberry leaves attenuate D-galactose-induced aging in vivo and in vitro. J Ethnopharmacol. 2023;311:116286. doi:10.1016/j.jep.2023.116286
   PubMed Web of Science ®Google Scholar
• Zhu S, Jia L, Wang X, et al. Anti-aging formula protects skin from oxidative stress-induced senescence through the inhibition of CXCR2 expression. J Ethnopharmacol. 2023;318(Pt B):116996. doi:10.1016/j.jep.2023.116996
   PubMedGoogle Scholar
• Shenghua P, Ziqin Z, Shuyu T, et al. An integrated fecal microbiome and metabolome in the aged mice reveal anti-aging effects from the intestines and biochemical mechanism of FuFang zhenshu TiaoZhi(FTZ). Biomed Pharmacother. 2020;121:109421. doi:10.1016/j.biopha.2019.109421
   PubMed Web of Science ®Google Scholar
• Teseo S, Houot B, Yang K, et al. G. sinense and P. notoginseng extracts improve healthspan of aging flies and provide protection in a Huntington disease model. Aging Dis. 2021;12(2):425–440. doi:10.14336/ad.2020.0714-1
   PubMed Web of Science ®Google Scholar
• Li L, Zhang H, Chen B, et al. BaZiBuShen alleviates cognitive deficits and regulates Sirt6/NRF2/HO-1 and Sirt6/P53-PGC-1α-TERT signaling pathways in aging mice. J Ethnopharmacol. 2022;282:114653. doi:10.1016/j.jep.2021.114653
   PubMed Web of Science ®Google Scholar
• Adler AS, Sinha S, Kawahara TL, et al. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev. 2007;21(24):3244–3257. doi:10.1101/gad.1588507
   PubMed Web of Science ®Google Scholar
• Zia A, Farkhondeh T, Pourbagher-Shahri AM, et al. The role of curcumin in aging and senescence: molecular mechanisms. Biomed Pharmacother. 2021;134:111119. doi:10.1016/j.biopha.2020.111119
   PubMed Web of Science ®Google Scholar
• Culig L, Chu X, Bohr VA. Neurogenesis in aging and age-related neurodegenerative diseases. Ageing Res Rev. 2022;78:101636. doi:10.1016/j.arr.2022.101636
   PubMed Web of Science ®Google Scholar
• Alzheimer’s Association. 2021 Alzheimer’s disease facts and figures. Alzheimers Dement. 2021;17(3):327–406. doi:10.1002/alz.12328
   PubMed Web of Science ®Google Scholar
• Calderón-Larrañaga A, Vetrano DL, Onder G, et al. Assessing and measuring chronic multimorbidity in the older population: a proposal for its operationalization. J Gerontol a Biol Sci Med Sci. 2017;72(10):1417–1423. doi:10.1093/gerona/glw233
   PubMed Web of Science ®Google Scholar
• Delgado-Lara DL, González-Enríquez GV, Torres-Mendoza BM, et al. Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson’s disease. Biomed Pharmacother. 2020;129:110485. doi:10.1016/j.biopha.2020.110485
   PubMed Web of Science ®Google Scholar
• Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nat Rev Dis Primers. 2017;3:17013. doi:10.1038/nrdp.2017.13
   PubMed Web of Science ®Google Scholar
• Pandya VA, Patani R. Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective. Brain. 2020;143(4):1057–1072. doi:10.1093/brain/awz360
   PubMedGoogle Scholar
• Xu L, Liu T, Liu L, et al. Global variation in prevalence and incidence of amyotrophic lateral sclerosis: a systematic review and meta-analysis. J Neurol. 2020;267(4):944–953. doi:10.1007/s00415-019-09652-y
   PubMed Web of Science ®Google Scholar
• Lane CA, Hardy J, Schott JM. Alzheimer’s disease. Eur J Neurol. 2018;25(1):59–70. doi:10.1111/ene.13439
   PubMed Web of Science ®Google Scholar
• Zhang Y, Lin C, Zhang L, et al. Cognitive improvement during treatment for mild Alzheimer’s disease with a Chinese Herbal Formula: a randomized controlled trial. PLoS One. 2015;10(6):e0130353. doi:10.1371/journal.pone.0130353
   PubMed Web of Science ®Google Scholar
• Ning F, Chen L, Chen L, et al. Combination of polygoni multiflori radix praeparata and acori tatarinowii rhizoma alleviates learning and memory impairment in scopolamine-treated mice by regulating synaptic-related proteins. Front Pharmacol. 2021;12:679573. doi:10.3389/fphar.2021.679573
   PubMed Web of Science ®Google Scholar
• Huang Q, Zhang C, Qu S, et al. Chinese herbal extracts exert neuroprotective effect in Alzheimer’s disease mouse through the dopaminergic synapse/apoptosis signaling pathway. Front Pharmacol. 2022;13:817213. doi:10.3389/fphar.2022.817213
   PubMed Web of Science ®Google Scholar
• Zhou Q, Wang Y, Zhang J, et al. Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Sci Rep. 2018;8(1):1668. doi:10.1038/s41598-018-19923-9
   PubMedGoogle Scholar
• Gong F, Zhu W, Liao W, et al. Mechanism of the curative effect of Wen-Shen-Jian-Pi prescription in the treatment of amyotrophic lateral sclerosis. Front Aging Neurosci. 2022;14:873224. doi:10.3389/fnagi.2022.873224
   PubMed Web of Science ®Google Scholar
• In S, Hong CW, Choi B, et al. Inhibition of mitochondrial clearance and Cu/Zn-SOD activity enhance 6-hydroxydopamine-induced neuronal apoptosis. Mol Neurobiol. 2016;53(1):777–791. doi:10.1007/s12035-014-9087-9
   PubMed Web of Science ®Google Scholar
• Holper L, Ben-Shachar D, Mann JJ. Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease. Neuropsychopharmacology. 2019;44(5):837–849. doi:10.1038/s41386-018-0090-0
   PubMed Web of Science ®Google Scholar
• Gao L, Cao M, Du GH, et al. Huangqin decoction exerts beneficial effects on rotenone-induced rat model of Parkinson’s disease by improving mitochondrial dysfunction and alleviating metabolic abnormality of mitochondria. Front Aging Neurosci. 2022;14:911924. doi:10.3389/fnagi.2022.911924
   PubMed Web of Science ®Google Scholar
• Geng J, Liu W, Gao J, et al. Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1. Br J Pharmacol. 2019;176(23):4574–4591. doi:10.1111/bph.14823
   PubMed Web of Science ®Google Scholar
• Li L, Fan S, Zhang W, et al. Duzhong fang attenuates the POMC-derived neuroinflammation in Parkinsonian mice. J Inflamm Res. 2021;14:3261–3276. doi:10.2147/jir.S316314
   PubMedGoogle Scholar
• Bao X, He Y, Huang L, et al. Sinomenine exerts a neuroprotective effect on PD mouse model through inhibiting PI3K/AKT/mTOR pathway to enhance autophagy. Int J Neurosci. 2022:1–9. doi:10.1080/00207454.2022.2100780
   Web of Science ®Google Scholar
• Liu XL, Lu J, Tian Y, et al. 艾灸激活Nrf2/ARE通路抗帕金森病模型大鼠氧化应激损伤的机制研究 [Effect and mechanism of moxibustion on oxidative stress injury in rats with Parkinson’s disease by activating Nrf2/ARE pathway]. Zhongguo Zhen Jiu. 2020;40(8):857–862. Chinese. doi:10.13703/j.0255-2930.20190620-k0002
   PubMedGoogle Scholar
• Gu SC, Shi R, Gaoag C, et al. Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson’s disease: a multicenter, randomized, double-blind, placebo-controlled study. Phytomedicine. 2023;108:154497. doi:10.1016/j.phymed.2022.154497
   PubMed Web of Science ®Google Scholar
• North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circ Res. 2012;110(8):1097–1108. doi:10.1161/circresaha.111.246876
   PubMed Web of Science ®Google Scholar
• Betts DH, Bain NT, Madan P. The p66(Shc) adaptor protein controls oxidative stress response in early bovine embryos. PLoS One. 2014;9(1):e86978. doi:10.1371/journal.pone.0086978
   PubMed Web of Science ®Google Scholar
• Chen MS, Lee RT, Garbern JC. Senescence mechanisms and targets in the heart. Cardiovasc Res. 2022;118(5):1173–1187. doi:10.1093/cvr/cvab161
   PubMed Web of Science ®Google Scholar
• Yan M, Sun S, Xu K, et al. Cardiac aging: from basic research to therapeutics. Oxid Med Cell Longev. 2021;2021:9570325. doi:10.1155/2021/9570325
   PubMed Web of Science ®Google Scholar
• Wu GS, Li HK, Zhang WD. Metabolomics and its application in the treatment of coronary heart disease with traditional Chinese medicine. Chin J Nat Med. 2019;17(5):321–330. doi:10.1016/s1875-5364(19)30037-8
   PubMed Web of Science ®Google Scholar
• Wang Y, Li Y, He C, et al. Mitochondrial regulation of cardiac aging. Biochim Biophys Acta Mol Basis Dis. 2019;1865(7):1853–1864. doi:10.1016/j.bbadis.2018.12.008
   PubMed Web of Science ®Google Scholar
• Li W, Zhang Y, Wang X, et al. Qishen granule protects against doxorubicin-induced cardiotoxicity by coordinating MDM2-p53-mediated mitophagy and mitochondrial biogenesis. Oxid Med Cell Longev. 2022;2022:4344677. doi:10.1155/2022/4344677
   PubMedGoogle Scholar
• Liu Y, Zhong H, Xu P, et al. Deciphering the combination mechanisms of Gualou-Xiebai herb pair against atherosclerosis by network pharmacology and HPLC-Q-TOF-MS technology. Front Pharmacol. 2022;13:941400. doi:10.3389/fphar.2022.941400
   PubMed Web of Science ®Google Scholar
• Li X, Su C, Jiang Z, et al. Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. NPJ Biofilms Microbiomes. 2021;7(1):36. doi:10.1038/s41522-021-00205-8
   PubMed Web of Science ®Google Scholar
• Wen B, Dang YY, Wu SH, et al. Antiatherosclerotic effect of dehydrocorydaline on ApoE(-/-) mice: inhibition of macrophage inflammation. Acta Pharmacol Sin. 2022;43(6):1408–1418. doi:10.1038/s41401-021-00769-3
   PubMed Web of Science ®Google Scholar
• Chen X, Cao J, Sun Y, et al. Ethanol extract of Schisandrae chinensis fructus ameliorates the extent of experimentally induced atherosclerosis in rats by increasing antioxidant capacity and improving endothelial dysfunction. Pharm Biol. 2018;56(1):612–619. doi:10.1080/13880209.2018.1523933
   PubMed Web of Science ®Google Scholar
• Pentikäinen MO, Oörni K, Ala-Korpela M, et al. Modified LDL - trigger of atherosclerosis and inflammation in the arterial intima. J Intern Med. 2000;247(3):359–370. doi:10.1046/j.1365-2796.2000.00655.x
   PubMed Web of Science ®Google Scholar
• Lin HH, Charles AL, Hsieh CW, et al. Antioxidant effects of 14 Chinese traditional medicinal herbs against human low-density lipoprotein oxidation. J Tradit Complement Med. 2015;5(1):51–55. doi:10.1016/j.jtcme.2014.10.001
   PubMedGoogle Scholar
• Jin X, Fu W, Zhou J, et al. Oxymatrine attenuates oxidized low‑density lipoprotein‑induced HUVEC injury by inhibiting NLRP3 inflammasome‑mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway. Int J Mol Med. 2021;48(4). doi:10.3892/ijmm.2021.5020
   Web of Science ®Google Scholar
• Cyr AR, Huckaby LV, Shiva SS, et al. Nitric Oxide and Endothelial Dysfunction. Crit Care Clin. 2020;36(2):307–321. doi:10.1016/j.ccc.2019.12.009
   PubMed Web of Science ®Google Scholar
• Zhu Z, Li J, Zhang X. Astragaloside IV Protects Against Oxidized Low-Density Lipoprotein (ox-LDL)-induced endothelial cell injury by reducing oxidative stress and inflammation. Med Sci Monit. 2019;25:2132–2140. doi:10.12659/msm.912894
   PubMed Web of Science ®Google Scholar
• Bennett MR, Sinha S, Owens GK. Vascular smooth muscle cells in atherosclerosis. Circ Res. 2016;118(4):692–702. doi:10.1161/circresaha.115.306361
   PubMed Web of Science ®Google Scholar
• Lee S, Lim HJ, Park HY, et al. Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model. Atherosclerosis. 2006;186(1):29–37. doi:10.1016/j.atherosclerosis.2005.06.048
   PubMed Web of Science ®Google Scholar
• Xu S, Ogura S, Chen J, et al. LOX-1 in atherosclerosis: biological functions and pharmacological modifiers. Cell Mol Life Sci. 2013;70(16):2859–2872. doi:10.1007/s00018-012-1194-z
   PubMed Web of Science ®Google Scholar
• Diao Y. Clematichinenoside AR alleviates foam Cell formation and the inflammatory response in Ox-LDL-Induced RAW264.7 cells by activating autophagy. Inflammation. 2021;44(2):758–768. doi:10.1007/s10753-020-01375-x
   PubMed Web of Science ®Google Scholar
• Badimon L, Padró T, Vilahur G. Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur Heart J Acute Cardiovasc Care. 2012;1(1):60–74. doi:10.1177/2048872612441582
   PubMedGoogle Scholar
• Wang H, Zhong L, Mi S, et al. Tanshinone IIA prevents platelet activation and down-regulates CD36 and MKK4/JNK2 signaling pathway. BMC Cardiovasc Disord. 2020;20(1):81. doi:10.1186/s12872-019-01289-z
   PubMed Web of Science ®Google Scholar
• Ke J, Li MT, Huo YJ, et al. The synergistic effect of ginkgo biloba extract 50 and aspirin against platelet aggregation. Drug Des Devel Ther. 2021;15:3543–3560. doi:10.2147/dddt.S318515
   PubMed Web of Science ®Google Scholar
• Palmer AK, Gustafson B, Kirkland JL, et al. Cellular senescence: at the nexus between ageing and diabetes. Diabetologia. 2019;62(10):1835–1841. doi:10.1007/s00125-019-4934-x
   PubMed Web of Science ®Google Scholar
• Kushner JA. The role of aging upon β cell turnover. J Clin Invest. 2013;123(3):990–995. doi:10.1172/jci64095
   PubMed Web of Science ®Google Scholar
• Xu M, Tchkonia T, Ding H, et al. JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age. Proc Natl Acad Sci U S A. 2015;112(46):E6301–E6310. doi:10.1073/pnas.1515386112
   PubMed Web of Science ®Google Scholar
• Berlanga-Acosta JA, Guillén-Nieto GE, Rodríguez-Rodríguez N, et al. Cellular senescence as the pathogenic hub of diabetes-related wound chronicity. Front Endocrinol. 2020;11:573032. doi:10.3389/fendo.2020.573032
   PubMed Web of Science ®Google Scholar
• Rong C, Yanmei C, Xiaofei Z, et al. Research progress in the correlation between diabetes mellitus and aging and its mechanism. Transl Med J. 2023;12(04):204–09+14.
   Google Scholar
• Zhao MM, Lu J, Li S, et al. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Nat Commun. 2021;12(1):5616. doi:10.1038/s41467-021-25952-2
   PubMed Web of Science ®Google Scholar
• Zhou X, Yang Q, Xie Y, et al. Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1. Neurobiol Aging. 2015;36(3):1462–1470. doi:10.1016/j.neurobiolaging.2014.11.002
   PubMed Web of Science ®Google Scholar
• Zhu Q, Zhou Q, Luo XL, et al. Combination of canagliflozin and puerarin alleviates the lipotoxicity to diabetic kidney in mice. Korean J Physiol Pharmacol. 2023;27(3):221–230. doi:10.4196/kjpp.2023.27.3.221
   PubMed Web of Science ®Google Scholar
• Zhou YT, Zhu L, Yuan Y, et al. Effects and mechanisms of five psoralea prenylflavonoids on aging-related diseases. Oxid Med Cell Longev. 2020;2020:2128513. doi:10.1155/2020/2128513
   PubMed Web of Science ®Google Scholar
• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. doi:10.3322/caac.21442
   PubMed Web of Science ®Google Scholar
• Fane M, Weeraratna AT. How the ageing microenvironment influences tumour progression. Nat Rev Cancer. 2020;20(2):89–106. doi:10.1038/s41568-019-0222-9
   PubMed Web of Science ®Google Scholar
• Efferth T. Cancer combination therapies with artemisinin-type drugs. Biochem Pharmacol. 2017;139:56–70. doi:10.1016/j.bcp.2017.03.019
   PubMed Web of Science ®Google Scholar
• Chen L, Qu C, Chen H, et al. Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PLoS One. 2014;9(4):e96177. doi:10.1371/journal.pone.0096177
   PubMed Web of Science ®Google Scholar
• Yao Y, Guo Q, Cao Y, et al. Artemisinin derivatives inactivate cancer-associated fibroblasts through suppressing TGF-β signaling in breast cancer. J Exp Clin Cancer Res. 2018;37(1):282. doi:10.1186/s13046-018-0960-7
   PubMedGoogle Scholar
• Yin S, Jin W, Qiu Y, et al. Solamargine induces hepatocellular carcinoma cell apoptosis and autophagy via inhibiting LIF/miR-192-5p/CYR61/Akt signaling pathways and eliciting immunostimulatory tumor microenvironment. J Hematol Oncol. 2022;15(1):32. doi:10.1186/s13045-022-01248-w
   PubMed Web of Science ®Google Scholar
• Zhang Y, Chai N, Wei Z, et al. YYFZBJS inhibits colorectal tumorigenesis by enhancing Tregs-induced immunosuppression through HIF-1α mediated hypoxia in vivo and in vitro. Phytomedicine. 2022;98:153917. doi:10.1016/j.phymed.2021.153917
   PubMed Web of Science ®Google Scholar
• Yang R, Pei T, Huang R, et al. Platycodon grandiflorum triggers antitumor immunity by restricting PD-1 expression of CD8(+) T cells in local tumor microenvironment. Front Pharmacol. 2022;13:774440. doi:10.3389/fphar.2022.774440
   PubMed Web of Science ®Google Scholar
• Jiang Z, Yang Y, Yang Y, et al. Ginsenoside Rg3 attenuates cisplatin resistance in lung cancer by downregulating PD-L1 and resuming immune. Biomed Pharmacother. 2017;96:378–383. doi:10.1016/j.biopha.2017.09.129
   PubMed Web of Science ®Google Scholar
• Song M, Qian C, Zhang T, et al. Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2/PGE2 cascade. J Ethnopharmacol. 2023;316:116735. doi:10.1016/j.jep.2023.116735
   PubMed Web of Science ®Google Scholar
• Guo J, Shen Y, Hu S, et al. Neobavaisoflavone inhibits antitumor immunosuppression via myeloid-derived suppressor cells. Int Immunopharmacol. 2022;111:109103. doi:10.1016/j.intimp.2022.109103
   PubMed Web of Science ®Google Scholar
• Lam W, Hu R, Liu SH, et al. YIV-906 enhances nuclear factor of activated T-cells (NFAT) activity of T cells and promotes immune checkpoint blockade antibody action and CAR T-cell activity. Front Pharmacol. 2022;13:1095186. doi:10.3389/fphar.2022.1095186
   PubMed Web of Science ®Google Scholar
• Ke M, Zhang Z, Xu B, et al. Baicalein and baicalin promote antitumor immunity by suppressing PD-L1 expression in hepatocellular carcinoma cells. Int Immunopharmacol. 2019;75:105824. doi:10.1016/j.intimp.2019.105824
   PubMed Web of Science ®Google Scholar
• Dupont C, Armant DR, Brenner CA. Epigenetics: definition, mechanisms and clinical perspective. Semin Reprod Med. 2009;27(5):351–357. doi:10.1055/s-0029-1237423
   PubMed Web of Science ®Google Scholar
• Rando TA, Chang HY. Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell. 2012;148(1–2):46–57. doi:10.1016/j.cell.2012.01.003
   PubMed Web of Science ®Google Scholar
• Schroeder EA, Raimundo N, Shadel GS. Epigenetic silencing mediates mitochondria stress-induced longevity. Cell Metab. 2013;17(6):954–964. doi:10.1016/j.cmet.2013.04.003
   PubMed Web of Science ®Google Scholar
• Law PP, Holland ML. DNA methylation at the crossroads of gene and environment interactions. Essays Biochem. 2019;63(6):717–726. doi:10.1042/ebc20190031
   PubMed Web of Science ®Google Scholar
• Lowe R, Barton C, Jenkins CA, et al. Ageing-associated DNA methylation dynamics are a molecular readout of lifespan variation among mammalian species. Genome Biol. 2018;19(1):22. doi:10.1186/s13059-018-1397-1
   PubMedGoogle Scholar
• Yang Y, Liu L, Zhang X, et al. Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2. Liver Int. 2020;40(1):141–154. doi:10.1111/liv.14262
   PubMed Web of Science ®Google Scholar
• Mao X, Hou Y, Fang C, et al. Bazi Bushen mitigates epigenetic aging and extends healthspan in naturally aging mice. Biomed Pharmacother. 2023;160:114384. doi:10.1016/j.biopha.2023.114384
   PubMed Web of Science ®Google Scholar
• Rossiello F, Jurk D, Passos JF, et al. Telomere dysfunction in ageing and age-related diseases. Nat Cell Biol. 2022;24(2):135–147. doi:10.1038/s41556-022-00842-x
   PubMed Web of Science ®Google Scholar
• Hansen M, Rubinsztein DC, Walker DW. Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol. 2018;19(9):579–593. doi:10.1038/s41580-018-0033-y
   PubMed Web of Science ®Google Scholar
• Pan Y, Liu Y, Fujii R, et al. Ehretiquinone from onosma bracteatum wall exhibits antiaging effect on yeasts and mammals through antioxidative stress and autophagy induction. Oxid Med Cell Longev. 2021;2021:5469849. doi:10.1155/2021/5469849
   PubMed Web of Science ®Google Scholar
• Shibu MA, Lin YJ, Chiang CY, et al. Novel anti-aging herbal formulation Jing Si displays pleiotropic effects against aging associated disorders. Biomed Pharmacother. 2022;146:112427. doi:10.1016/j.biopha.2021.112427
   PubMed Web of Science ®Google Scholar
• Wu E, Lian Y, Zhao S, et al. Involvement of the Sch9/Rim15/Msn2 signaling pathway in the anti-aging activity of dendrobine from Dendrobium nobile Lindl. via modification of oxidative stress and autophagy. Chin Med. 2023;18(1):111. doi:10.1186/s13020-023-00827-4
   PubMed Web of Science ®Google Scholar
• van Deursen JM. The role of senescent cells in ageing. Nature. 2014;509(7501):439–446. doi:10.1038/nature13193
   PubMed Web of Science ®Google Scholar
• Qin W, Chen S, Yang S, et al. The effect of traditional Chinese medicine on neural stem cell proliferation and differentiation. Aging Dis. 2017;8(6):792–811. doi:10.14336/ad.2017.0428
   PubMed Web of Science ®Google Scholar
• Bai L, Shi GY, Yang YJ, et al. Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells. Animal Model Exp Med. 2018;1(3):194–202. doi:10.1002/ame2.12034
   PubMedGoogle Scholar
• Cai SZ, Zhao LN, Liu J, et al. Allicin alleviates lead-induced hematopoietic stem cell aging by up-regulating PKM2. Biosci Rep. 2019;39(7). doi:10.1042/bsr20190243
   Google Scholar
• Lei Z, Chen L, Hu Q, et al. Ginsenoside Rb1 improves intestinal aging via regulating the expression of sirtuins in the intestinal epithelium and modulating the gut microbiota of mice. Front Pharmacol. 2022;13:991597. doi:10.3389/fphar.2022.991597
   PubMed Web of Science ®Google Scholar
• Li Y, Zhang L, Ren P, et al. Qing-Xue-Xiao-Zhi formula attenuates atherosclerosis by inhibiting macrophage lipid accumulation and inflammatory response via TLR4/MyD88/NF-κB pathway regulation. Phytomedicine. 2021;93:153812. doi:10.1016/j.phymed.2021.153812
   PubMed Web of Science ®Google Scholar
• Shen Z, Yu M, Zhang S. Network pharmacology and molecular docking analyses unveil the mechanisms of yiguanjian decoction against Parkinson’s disease from inner/outer brain perspective. Biomed Res Int. 2022;2022:4758189. doi:10.1155/2022/4758189
   PubMed Web of Science ®Google Scholar
• Hao J, Bei J, Li Z, et al. Qing`e Pill inhibits osteoblast ferroptosis via ATM Serine/Threonine Kinase (ATM) and the PI3K/AKT pathway in primary osteoporosis. Front Pharmacol. 2022;13:902102. doi:10.3389/fphar.2022.902102
   PubMed Web of Science ®Google Scholar
• Chen GY, Liu XY, Luo J, et al. Integrating network pharmacology and experimental validation to explore the key mechanism of gubitong recipe in the treatment of osteoarthritis. Comput Math Methods Med. 2022;2022:7858925. doi:10.1155/2022/7858925
   PubMed Web of Science ®Google Scholar
• Liu X, Deng R, Chen Y, et al. Jian-Pi-Yi-Shen formula improves adenine-induced chronic kidney disease via regulating tryptophan metabolism and Aryl hydrocarbon receptor signaling. Front Pharmacol. 2022;13:922707. doi:10.3389/fphar.2022.922707
   PubMed Web of Science ®Google Scholar
• Liu X, Deng R, Wei X, et al. Jian-Pi-Yi-Shen formula enhances perindopril inhibition of chronic kidney disease progression by activation of SIRT3, modulation of mitochondrial dynamics, and antioxidant effects. Biosci Rep. 2021;41(10). doi:10.1042/bsr20211598
   Web of Science ®Google Scholar
• Gao K, Yang R, Zhang J, et al. Effects of Qijian mixture on type 2 diabetes assessed by metabonomics, gut microbiota and network pharmacology. Pharmacol Res. 2018;130:93–109. doi:10.1016/j.phrs.2018.01.011
   PubMed Web of Science ®Google Scholar
• Zhao P, Li J, Tian Y, et al. Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula. J Ethnopharmacol. 2018;217:152–162. doi:10.1016/j.jep.2018.02.023
   PubMed Web of Science ®Google Scholar
• Zhu J, Mu X, Zeng J, et al. Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging. PLoS One. 2014;9(6):e101291. doi:10.1371/journal.pone.0101291
   PubMed Web of Science ®Google Scholar
• Lei H, Wang B, Li WP, et al. Anti-aging effect of astragalosides and its mechanism of action. Acta Pharmacol Sin. 2003;24(3):230–234.
   PubMed Web of Science ®Google Scholar
• Zhang H, Pan N, Xiong S, et al. Inhibition of polyglutamine-mediated proteotoxicity by Astragalus membranaceus polysaccharide through the DAF-16/FOXO transcription factor in Caenorhabditis elegans. Biochem J. 2012;441(1):417–424. doi:10.1042/bj20110621
   PubMedGoogle Scholar
• Salvador L, Singaravelu G, Harley CB, et al. A natural product telomerase activator lengthens telomeres in humans: a randomized, double blind, and placebo controlled study. Rejuvenation Res. 2016;19(6):478–484. doi:10.1089/rej.2015.1793
   PubMed Web of Science ®Google Scholar
• Cuong VT, Chen W, Shi J, et al. The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans. Exp Gerontol. 2019;117:99–105. doi:10.1016/j.exger.2018.11.016
   PubMed Web of Science ®Google Scholar
• Liu P, Zhao H, Luo Y. Anti-aging implications of Astragalus Membranaceus (Huangqi): a well-known Chinese tonic. Aging Dis. 2017;8(6):868–886. doi:10.14336/ad.2017.0816
   PubMed Web of Science ®Google Scholar
• Kim EN, Lim JH, Kim MY, et al. Resveratrol, an Nrf2 activator, ameliorates aging-related progressive renal injury. Aging. 2018;10(1):83–99. doi:10.18632/aging.101361
   PubMedGoogle Scholar
• Wang TH, Tseng WC, Leu YL, et al. The flavonoid corylin exhibits lifespan extension properties in mouse. Nat Commun. 2022;13(1):1238. doi:10.1038/s41467-022-28908-2
   PubMed Web of Science ®Google Scholar
• Sun J, Jing S, Jiang R, et al. Metabolomics study of the therapeutic mechanism of Schisandra chinensis lignans on aging rats induced by d-galactose. Clin Interv Aging. 2018;13:829–841. doi:10.2147/cia.S163275
   PubMed Web of Science ®Google Scholar
• Liang CY, Liang YM, Liu HZ, et al. Effect of Dendrobium officinale on D-galactose-induced aging mice. Chin J Integr Med. 2017. doi:10.1007/s11655-016-2631-x
   Google Scholar