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Clinical Pharmacology: Advances and Applications Volume 16, 2024 - Issue
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CASE SERIES

Severe Hypertensive Response to Atropine Therapy for Bradycardia Associated with Dexmedetomidine: Case Report and Literature Review

Yong Li1 Department of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
,
Ju Gao1 Department of Anesthesiology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu Province, People’s Republic of China
,
Lin Jiang2 Department of Anesthesiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu Province, People’s Republic of China
,
Canlin Sun2 Department of Anesthesiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu Province, People’s Republic of China
,
Hua Hong2 Department of Anesthesiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu Province, People’s Republic of China
&
Dapeng Yu2 Department of Anesthesiology, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, Jiangsu Province, People’s Republic of ChinaCorrespondence[email protected]
Pages 27-31 | Received 26 Sep 2023, Accepted 23 Dec 2023, Published online: 11 Jan 2024

References

  • Belleville JP, Ward DS, Bloor BC, et al. Effects of intravenous dexmedetomidine in humans. I. Sedation, ventilation, and metabolic rate. Anesthesiology. 1992;77(6):1125–1133. doi:10.1097/00000542-199212000-00013
  • Ahmed S, Murugan R. Dexmedetomidine use in the ICU: are we there yet? Crit Care. 2013;17(3):320. doi:10.1186/cc12707
  • Ebert TJ, Hall JE, Barney JA, et al. The effects of increasing plasma concentrations of dexmedetomidine in humans. J Am Soc Anesthesiologists. 2000;93(2):382–394.
  • Bloor BC, Ward DS, Belleville JP, Maze M. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology. 1992;77(6):1134–1142. doi:10.1097/00000542-199212000-00014
  • Kaur M, Singh PM. Current role of dexmedetomidine in clinical anesthesia and intensive care. Anesthesia. 2011;5(2):128.
  • Erkonen G, Lamb F, Tobias JD. High-dose dexmedetomidine-induced hypertension in a child with traumatic brain injury. Neurocritical Care. 2008;9(3):366. doi:10.1007/s12028-008-9102-y
  • Shah S, Sangari T, Qasim M, et al. Severe hypertension and bradycardia after dexmedetomidine for radiology sedation in a patient with acute transverse myelitis. Pediatr Anesthesia. 2008;18(7):681–682. doi:10.1111/j.1460-9592.2008.02521.x
  • Mason KP, Zgleszewski S, Forman RE, et al. An exaggerated hypertensive response to glycopyrrolate therapy for bradycardia associated with high-dose dexmedetomidine. Anesthesia Analg. 2009;108(3):906–908. doi:10.1213/ane.0b013e3181948a6f
  • Kukoyi AT, Coker SA, Lewis LD, et al. Two cases of acute dexmedetomidine withdrawal syndrome following prolonged infusion in the intensive care unit Report of cases and review of the literature. Hum Exp Toxicol. 2012;32(1):107–110.
  • Muthiah T, Moni A, Mathews L, et al. Intravenous labetolol in treating hypertensive crisis following dexmedetomidine infusion for procedural sedation. J Clin Anesth. 2016;29:30–32. doi:10.1016/j.jclinane.2015.10.011
  • Flieller LA, Alaniz C, Pleva MR, et al. Incidence of rebound hypertension after discontinuation of dexmedetomidine. Pharmacotherapy. 2019;39(10):970–974. doi:10.1002/phar.2323
  • Salah J, Grgurich P, Nault K, et al. Identification of risk factors for hypertension and tachycardia upon dexmedetomidine discontinuation. J Crit Care. 2020;59:81–85. doi:10.1016/j.jcrc.2020.06.006
  • Wajima Z, Shiga T, Imanaga K. Does intravenous atropine affect stroke volume variation in man? Acta Anaesthesiologica Taiwanica. 2015;53(3):85–88. doi:10.1016/j.aat.2015.06.002
  • Congdon JM, Marquez M, Niyom S, et al. Evaluation of the sedative and cardiovascular effects of intramuscular administration of dexmedetomidine with and without concurrent atropine administration in dogs. J Am Vet Med Assoc. 2011;239(1):81–89. doi:10.2460/javma.239.1.81
  • Hunter JM, Flockton EA. The doughnut and the hole: a new pharmacological concept for anaesthetists. Br J Anaesth. 2006;97(2):123–126. doi:10.1093/bja/ael158

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