97
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Biological Depiction of Lipodystrophy and Its Associated Challenges Among HIV AIDS Patients: Literature Review

ORCID Icon
Pages 123-132 | Received 21 Nov 2023, Accepted 08 Mar 2024, Published online: 04 Apr 2024

References

  • Santini DAVF, Santini F. Diagnosis and treatment of lipodystrophy: a step - by - step approach. J Endocrinol Invest. 2019;42(1):61–73. doi:10.1007/s40618-018-0887-z
  • Awino McLigeyo A, Lule G, Otieno FCF, Joshua Kyateesa Kayima EO. Human immunodeficiency virus (HIV) associated lipodystrophy: the prevalence, severity and phenotypes in patients on highly active anti-retroviral therapy (HAART) in Kenya. J AIDS HIV Res. 2013;5(4):107–114.
  • López-dupla M, Maymó-masip E, Martínez E, Domingo P. HIV-1 / HAART-Related Lipodystrophy Syndrome (HALS) is associated with decreased circulating sTWEAK levels. PLoS One. 2015;10(12):1–13. doi:10.1371/journal.pone.0144789
  • Gomes L, Lana C, Rezende D, Junqueira G, Perini E, Pádua De CM. Lipodystrophy among patients with HIV infection on antiretroviral therapy: a systematic review protocol. BMJ Open. 2014;4:10–13.
  • Barton N, Moore R, Prasad K, Evans G. Excisional lipectomy versus liposuction in HIV-associated lipodystrophy. Arch Plast Surg. 2021;48(6):685–690.
  • Martinez E, Mocroft A, García-viejo MA, et al. Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study. Lancet. 2001;357(February 24):592–598. doi:10.1016/S0140-6736(00)04056-3
  • Siqueira LR, Holanda G, Teresinha M, et al. Effect of lipodystrophy on self-esteem and adherence to antiretroviral therapy in people living with HIV. AIDS Care. 2021;1(1):1–10. doi:10.1080/09540121.2021.1936442
  • Grenha I, Oliveira J, Lau E, et al. HIV-Infected Patients With and Without Lipodystrophy Under Combined Antiretroviral Therapy: evaluation of Body Composition. J Clin Densitom. 2018;21(1):75–82. doi:10.1016/j.jocd.2016.07.010
  • Dragovi G, Danilovi D, Dimi A, Jevtovi D. Lipodystrophy induced by combination antiretroviral therapy in HIV / AIDS patients: a Belgrade cohort study. Vojn Pregl. 2014;71(8):746–750. doi:10.2298/VSP121016022D
  • Bouatou Y, Gayet Ageron A, Bernasconi E, et al. Lipodystrophy Increases the Risk of CKD Development in HIV-Positive Patients in Switzerland: the LIPOKID Study. Kidney Int Reports. 2018;3(5):1089–1099. doi:10.1016/j.ekir.2018.04.014
  • Finkelstein JL, Gala P, Rochford R, Glesby MJ, Mehta S. HIV/AIDS and lipodystrophy: implications for clinical management in resource-limited settings. J Int AIDS Soc. 2015;18(1):1–13. doi:10.7448/IAS.18.1.19033
  • Leow MK, Addy CL and Mantzoros CS. (2003). Human immunodeficiency Virus/Highly active antiretroviral therapy-associated metabolic syndrome: clinical presentation, pathophysiology, and therapeutic strategies. J Clin Endocr Metab, 88(5), 1961–1976. 10.1210/jc.2002-021704
  • Sacilotto LB, Papini SJ, Mendes AL, et al. Relationship Between Lipodystrophy, Body Composition, Metabolic Profile, and Serum Levels of Adipocytokines. Front Nutr. 2021;8(December). doi:10.3389/fnut.2021.750721
  • Marcelle D, Sprinz E. HIV-associated lipodystrophy: a review from a Brazilian perspective. Ther Clin Risk Manag. 2014;10:559–566. doi:10.2147/TCRM.S35075
  • Bhutia E, Hemal A, Yadav TP, Ramesh KL. Lipodystrophy syndrome among HIV infected children on highly active antiretroviral therapy in northern India. Afr Health Sci. 2014;14(2):408–413. doi:10.4314/ahs.v14i2.17
  • Araújo-Vilar FS. Diagnosis and treatment of lipodystrophy: a step - by - step approach. J Endocrinol Invest. 2019;42(1):61–73. doi:10.1007/s40618-018-0887-z
  • Della JLB, Luiz MC, Maurici R, Schuelter-Trevisol F. Prevalence and factors associated with lipodystrophy in AIDS patients. Rev Soc Bras Med Trop. 2014;47(1):30–37. doi:10.1590/0037-8682-0240-2013
  • Kinabo GD, Sprengers M, Msuya LJ. Prevalence of Lipodystrophy in HIV-infected Children in Tanzania on Highly Active Antiretroviral Therapy. Pediatr Infect Dis J. 2013;32(1):39–44. doi:10.1097/INF.0b013e3182755a34
  • Tshamala HK, Aketi L, Tshibassu PM, et al. The Lipodystrophy Syndrome in HIV-Infected Children under Antiretroviral Therapy: a First Report from the Central Africa. Int J Pediatr. 2019;2019.
  • Palmeira Dos Santos TM, Barros Da Silva D, Monteiro Franco T, et al. Lipodystrophy and the relationship with cardiovascular risk factors and metabolic syndrome in HIV-infected patients. Nutr Clin y Diet Hosp. 2017;37(2):12–20.
  • Iwuala SO, Lesi OA, Fasanmade OA, Sabir AA, Olamoyegun MA, Okany CC. Prevalence of and Risk Factors for Lipoatrophy in Patients with HIV Infection in Nigeria. AIDS Res Treat. 2015;1–8.
  • Kalyanasundaram AP, Jacob SM, Hemalatha R, Sivakumar MR. Prevalence of lipodystrophy and dyslipidemia among patients with HIV infection on generic ART in rural South India. J Int Assoc Physicians AIDS Care. 2012;11(5):329–334. doi:10.1177/1545109711401750
  • Aurpibul L, Puthanakit T, Taejaroenkul S, Sirisanthana T, Sirisanthana V. Recovery From Lipodystrophy in HIV – infected Children After Substitution of Stavudine With Zidovudine in a Non-nucleoside Reverse Transcriptase Inhibitor – based. Pediatr Infect Dis J. 2012;31(4):384–388. doi:10.1097/INF.0b013e31823f0e11
  • Tsuda LC, Silva MM, Machado AA, Fernandes APM. Body changes: antiretroviral therapy and lipodystrophy syndrome in people living with HIV/AIDS. Rev Lat Am Enfermagem. 2012;20(5):847–853. doi:10.5999/aps.2020.02285
  • Bwakura-dangarembizi M, Musiime V, Szubert AJ, et al. Prevalence of Lipodystrophy and Metabolic Abnormalities in HIV-infected African Children after 3 Years on First-line Antiretroviral Therapy. Int J Med. 2015;34(2):23–31.
  • Bouatou Y, Ageron AG, Bernasconi E, et al. Development in HIV-Positive Patients in Switzerland: the LIPOKID Study. Kidney Int Reports. 2018;3(5):1089–1099. doi:10.1016/j.ekir.2018.04.014
  • Beraldo RA, Dos Santos AP, Guimarães MP, et al. Body fat redistribution and changes in lipid and glucose metabolism in people living with HIV/AIDS. Rev Bras Epidemiol. 2017;20(3):526–536. doi:10.1590/1980-5497201700030014
  • Safar Zadeh E, Lungu AO, Cochran EK, et al. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol. 2013;59(1):131–137. doi:10.1016/j.jhep.2013.02.007
  • Nzuza S, Zondi S, Hurchund R. Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome and Lipodystrophy. Pathophysiology and Current Therapeutic Interventions. 2017;7(4):103–116.
  • Tsiodras S, Poulia K, Yannakoulia M, et al. Adherence to Mediterranean diet is favorably associated with metabolic parameters in HIV-positive patients with the highly active antiretroviral therapy – induced metabolic syndrome and lipodystrophy. Metabolism. 2009;58(6):854–859. doi:10.1016/j.metabol.2009.02.012
  • Guira O, Tiéno H, Yaméogo B, et al. Characteristics and factors associated with the clinical forms of lipoatrophy during highly active antiretroviral therapy in Ouagadougou, Burkina Faso. J Int Assoc Provid AIDS Care. 2014;13(2):184–187. doi:10.1177/2325957413503369
  • Méndez ES, Prado AA, José M, Ruiz F. Correlates of perception of HIV-related lipodystrophy: the importance of fears and concerns. Revistamultidiscipliardelsida. 2015;1(4):20–29.
  • Verolet CM, Delhumeau-Cartier C, Sartori M, et al. Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders. AIDS Res Ther. 2015;12(1):1–10. doi:10.1186/s12981-015-0061-z
  • Fiorenza CG, Chou SH, Mantzoros CS. Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol. 2011;7(3):137–150. doi:10.1038/nrendo.2010.199
  • Nilmaria Guzman VV. HIV-Associated Lipodystrophy. Treasure Island(FL): Stat Pearls; 2022:1–8.
  • Da Silva TAL, Barboza RR, De Andrade RD, et al. Relationship between dietary intake and use of protease inhibitors with anthropometric and biochemical parameters of lipodystrophy in people living with HIV. Nutr Hosp. 2014;30(4):935–940. doi:10.3305/nh.2014.30.4.7638
  • Sacre HP, Chalmers R, Tudor-Williams G, Klassen K, Foster C, Walters RMP. Clinic-based anthropometric measurements of lipodystrophy and associations with antiretroviral therapy in HIV-infected adolescents. HIV Med. 2012;13:78.
  • Iwuala SO, Lesi OA, Fasanmade OA, Sabir AA, Olamoyegun MA, Okany CC. Prevalence of and risk factors for lipoatrophy in patients with HIV infection in Nigeria. AIDS Res Treat. 2015;2015:1–7. doi:10.1155/2015/402638
  • Price J, Hoy J, Ridley E, Nyulasi I, Paul E, Woolley I. Changes in the prevalence of lipodystrophy, metabolic syndrome and cardiovascular disease risk in HIV-infected men. Sex Health. 2015;12(3):240–248. doi:10.1071/SH14084
  • Meehan CA, Cochran E, Kassai A, Brown RJ, Gorden P. Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy. Expert Rev Clin Pharmacol. 2016;9(1):59–68. doi:10.1586/17512433.2016.1096772
  • Polyzos SA, Perakakis N, Mantzoros CS. Fatty liver in lipodystrophy: a review with a focus on therapeutic perspectives of adiponectin and/or leptin replacement. Metabolism. 2019;96:66–82. doi:10.1016/j.metabol.2019.05.001
  • Akini G, Merve Celik BA. Complications of lipodystrophy syndromes. Presse Med. 2021;50(3):1–7.
  • Bruder-Nascimento T, Kress TC, Kennard S, De CEJB. HIV Protease Inhibitor Ritonavir Impairs Endothelial Function Via Reduction in Adipose Mass and Endothelial Leptin Receptor-Dependent Increases in NADPH Oxidase 1 (Nox1), C-C Chemokine Receptor Type 5 (CCR5), and Inflammation Thiago. J Am Hear Assoc. 2020;9:1–25.
  • Alves MD, Brites C, Sprinz E. HIV -associated lipodystrophy: a review from a Brazilian perspective. Ther Clin Risk Manag. 2014;10(1):559–566.
  • Koethe JR, Lagathu C, Lake JE, et al. HIV and antiretroviral therapy-related fat alterations. Nat Rev Dis Primers. 2020;6(1). doi:10.1038/s41572-020-0181-1
  • Diker-Cohen T, Cochran E, Gorden P, Brown RJ. Partial and generalized lipodystrophy: comparison of baseline characteristics and response to metreleptin. J Clin Endocrinol Metab. 2015;100(5):1802–1810. doi:10.1210/jc.2014-4491