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The Women's Oncology Review
The Journal of Interdisciplinary Current Awareness
Volume 6, 2007 - Issue 1-2
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Original Article

Proliferation and apoptosis as markers of benefit in neoadjuvant endocrine therapy of breast cancer

Mitch Dowsett, Ian E. Smith, Steve R. Ebbs, et al. Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combination: influence of hormonal status and HER-2 in breast cancer_a study from the IMPACT trialists. Clin Cancer Res 2006;Feb 1;12(3 Pt 2):1024s–1030s.

Pages 111-113 | Published online: 04 Dec 2011

References

  • ATAC Trialists' Group. Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after comple-tion of 5 years' adjuvant treatment for breast cancer. Lancet 2005;365:60–62
  • Dowsett M, Ebbs SR, Dixon JM, et al. Biomarker changes during neoadjuvant anastrozole, tamoxifen, or the combi-nation: influence of hormonal status and HER-2 in breast cancer_a study from the IMPACT trialists. J Clin Oncol 2005;23:2477–2492
  • Dowsett M, Smith IE, Ebbs SR, et al. Short-term changes in Ki-67 during neoadjuvant treatment of primary breast cancer with anastrozole or tamoxifen alone or combined correlate with recurrence-free survival. Clin Cancer Res 2005;11:951-958s
  • Dowsett M, Smith I, on behalf of the IMPACT Trialists. Greater Ki67 response after 2 weeks neoadjuvant treatment with anastrozole than with tamoxifen or anastrozole plus tamoxifen in the IMPACT trial: a potential predictor of relapse-free survival [abstract 2]. Breast Cancer Res Treat 2003;82: 56

Further reading

  • Tao Y, Klause A, Vickers A, Bae K, Ellis M. Clinical and biomarker endpoint analysis in neoadjuvant endocrine therapy trials. Journal of Steroid Biochemistry & Molecular Biology 2005;95:91–95
  • Winer EP, Hudis C, Burstein HJ, et al. Assessment on the use of aromatase inhibitors as adjuvant therapy for post-menopausal women with hormone receptor—positive breast cancer: Status Report 2004. J Clin Oncol 2004; 23:619–629

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