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mAbs Volume 16, 2024 - Issue 1
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Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

Wei-Ching Lianga Department of Antibody Engineering, Genentech Inc, South San Francisco, CA, USAView further author information
,
Hongkang Xia Department of Antibody Engineering, Genentech Inc, South San Francisco, CA, USAView further author information
,
Dawei Sunb Department of Structural Biology, Genentech Inc, South San Francisco, CA, USAView further author information
,
Luigi D’Ascenzob Department of Structural Biology, Genentech Inc, South San Francisco, CA, USAView further author information
,
Jonathan Zarzarc Department of Pharma Technical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Nicole Stephensc Department of Pharma Technical Development, Genentech Inc, South San Francisco, CA, USAView further author information
,
Ryan Cookd Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USAView further author information
,
Yinyin Lid Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USAView further author information
,
Zhengmao Yed Department of Biochemical and Cellular Pharmacology, Genentech Inc, South San Francisco, CA, USA;e Discovery Science & Technology Department, Gilead Sciences Inc, Foster City, CA, USAView further author information
,
Marissa Matsumotob Department of Structural Biology, Genentech Inc, South San Francisco, CA, USA;f Asher Biotherapeutics, South San Francisco, CA, USAView further author information
,
Jian Payandehb Department of Structural Biology, Genentech Inc, South San Francisco, CA, USA;g Exelixis Inc, Alameda, CA, USAView further author information
,
Matthieu Masureelb Department of Structural Biology, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
View further author information
&
Yan Wua Department of Antibody Engineering, Genentech Inc, South San Francisco, CA, USACorrespondence[email protected]
View further author information
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Article: 2309685 | Received 12 Nov 2023, Accepted 21 Jan 2024, Published online: 14 Feb 2024

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