Drug Metabolism Reviews, Volume 31, Issue 2 (1999)

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Drug Metabolism Reviews, Volume 31, Issue 2 (1999)

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Research Article

Article
ALFRED HILDEBRANDT: FROM BASIC RESEARCH TO CLINICAL APPLICATION AND DRUG REGULATION
H. GREIM
Pages: 309-315
Published online: 05 Dec 1999
First Page PreviewforALFRED HILDEBRANDT: FROM BASIC RESEARCH TO CLINICAL APPLICATION AND DRUG REGULATION | Full Text | References | PDF (52.5 KB)
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Article
DISCOVERING THE FUNCTIONS OF CYTOCHROME P450 IN DRUG METABOLISM: THE ROLE OF ALFRED HILDEBRANDT
RONALD W. ESTABROOK
Pages: 317-331
Published online: 05 Dec 1999
First Page PreviewforDISCOVERING THE FUNCTIONS OF CYTOCHROME P450 IN DRUG METABOLISM: THE ROLE OF ALFRED HILDEBRANDT | Full Text | References | PDF (76.1 KB)
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Article
BIOCHEMICAL DIVERSITY OF PEPTIDE-HORMONE-DEPENDENT REGULATION OF STEROIDOGENIC P450S
NORIO KAGAWA, LARRY J. BISCHOF, PO-YUNG CHENG, AZLINDA ANWAR & MICHAEL R. WATERMAN
Pages: 333-342
Published online: 05 Dec 1999
First Page PreviewforBIOCHEMICAL DIVERSITY OF PEPTIDE-HORMONE-DEPENDENT REGULATION OF STEROIDOGENIC P450S | Full Text | References | PDF (65.9 KB)
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Article
PEROXYNITRITE INACTIVATES PROSTACYCLIN SYNTHASE BY HEME–THIOLATE-CATALYZED TYROSINE NITRATION
MINGHUI ZOU, AKIN YESILKAYA & VOLKER ULLRICH
Pages: 343-349
Published online: 05 Dec 1999
AbstractforPEROXYNITRITE INACTIVATES PROSTACYCLIN SYNTHASE BY HEME–THIOLATE-CATALYZED TYROSINE NITRATION | Full Text | References | PDF (46.7 KB)
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Article
INTERACTIONS BETWEEN CYTOCHROME P450 AND CYTOCHROME b5
JOHN B. SCHENKMAN & INGELA JANSSON
Pages: 351-364
Published online: 05 Dec 1999
First Page PreviewforINTERACTIONS BETWEEN CYTOCHROME P450 AND CYTOCHROME b5 | Full Text | References | PDF (76.5 KB)
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Article
PHENOBARBITAL-MEDIATED CHANGES IN GENE EXPRESSION IN THE LIVER
URS A. MEYER & KLAUS HOFFMANN
Pages: 365-373
Published online: 05 Dec 1999
First Page PreviewforPHENOBARBITAL-MEDIATED CHANGES IN GENE EXPRESSION IN THE LIVER | Full Text | References | PDF (55 KB)
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Article
INDUCTION OF CYP1A BY VARIOUS BENZIMIDAZOLES AND ITS SIGNIFICANCE IN ADMINISTRATIVE DRUG REGULATION
ULLRICH KLEEBERG, ROLAND FRÖTSCHL, SOLVEIGH KRUSEKOPF, JÜRGEN BROCKMÖLLER, IVAR ROOTS, KLAUS RUCKPAUL & ALFRED G. HILDEBRANDT
Pages: 381-392
Published online: 05 Dec 1999
First Page PreviewforINDUCTION OF CYP1A BY VARIOUS BENZIMIDAZOLES AND ITS SIGNIFICANCE IN ADMINISTRATIVE DRUG REGULATION | Full Text | References | PDF (365 KB)
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Article
REGULATION OF ENDOPLASMIC RETICULUM BIOGENESIS IN RESPONSE TO CYTOCHROME P450 OVERPRODUCTION*,†
G. SANDIG, E. KÄRGEL, R. MENZEL, F. VOGEL, T. ZIMMER & W.-H. SCHUNCK
Pages: 393-410
Published online: 05 Dec 1999
First Page PreviewforREGULATION OF ENDOPLASMIC RETICULUM BIOGENESIS IN RESPONSE TO CYTOCHROME P450 OVERPRODUCTION*,† | Full Text | References | PDF (738.1 KB)
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Article
FUNCTIONS AND TRANSCRIPTIONAL REGULATION OF PAH-INDUCIBLE HUMAN UDP-GLUCURONOSYL-TRANSFERASES
KARL WALTER BOCK, HARALD GSCHAIDMEIER, HORST HEEL, TOBIAS LEHMKÖSTER, PETER A. MÜNZEL & BARBARA S. BOCK-HENNIG
Pages: 411-422
Published online: 05 Dec 1999
First Page PreviewforFUNCTIONS AND TRANSCRIPTIONAL REGULATION OF PAH-INDUCIBLE HUMAN UDP-GLUCURONOSYL-TRANSFERASES | Full Text | References | PDF (127.8 KB)
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Article
MOLECULAR STUDIES ON THE TOXIFYING EFFECTS BY GENETICALLY ENGINEERED CYTOCHROMES P450
J. DOEHMER, J. T. M. BUTERS, A. LUCH, V. SOBALLA, W. M. BAIRD, H. MORISSON, J. J. STEGEMAN, A. J. TOWNSEND, W. F. GREENLEE, H. R. GLATT, A. SEIDEL, J. JACOB & H. GREIM
Pages: 423-435
Published online: 05 Dec 1999
First Page PreviewforMOLECULAR STUDIES ON THE TOXIFYING EFFECTS BY GENETICALLY ENGINEERED CYTOCHROMES P450 | Full Text | References | PDF (242 KB)
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Article
CYTOCHROME P450-NULL MICE
JEROEN T. M. BUTERS, JOHANNES DOEHMER & FRANK J. GONZALEZ
Pages: 437-447
Published online: 05 Dec 1999
First Page PreviewforCYTOCHROME P450-NULL MICE | Full Text | References | PDF (73 KB)
  • 142 Views
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Article
DUPLICATION, MULTIDUPLICATION, AND AMPLIFICATION OF GENES ENCODING DRUG-METABOLIZING ENZYMES: EVOLUTIONARY, TOXICOLOGICAL, AND CLINICAL PHARMACOLOGICAL ASPECTS
M. INGELMAN-SUNDBERG
Pages: 449-459
Published online: 05 Dec 1999
First Page PreviewforDUPLICATION, MULTIDUPLICATION, AND AMPLIFICATION OF GENES ENCODING DRUG-METABOLIZING ENZYMES: EVOLUTIONARY, TOXICOLOGICAL, AND CLINICAL PHARMACOLOGICAL ASPECTS | Full Text | References | PDF (141 KB)
  • 121 Views
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Article
GENETIC EPIDEMIOLOGY OF ENVIRONMENTAL TOXICITY AND CANCER SUSCEPTIBILITY: HUMAN ALLELIC POLYMORPHISMS IN DRUG-METABOLIZING ENZYME GENES, THEIR FUNCTIONAL IMPORTANCE, AND NOMENCLATURE ISSUES
DANIEL W. NEBERT, MAGNUS INGELMAN-SUNDBERG & ANN K. DALY
Pages: 467-487
Published online: 05 Dec 1999
AbstractforGENETIC EPIDEMIOLOGY OF ENVIRONMENTAL TOXICITY AND CANCER SUSCEPTIBILITY: HUMAN ALLELIC POLYMORPHISMS IN DRUG-METABOLIZING ENZYME GENES, THEIR FUNCTIONAL IMPORTANCE, AND NOMENCLATURE ISSUES | Full Text | References | PDF (115.7 KB)
  • 176 Views
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Article
ARYLAMINE N-ACETYLTRANSFERASE ACTIVITY IN MAN
INGOLF CASCORBI, JÜRGEN BROCKMÖLLER, PRZEMYSLAW M. MROZIKIEWICZ, ANTJE MÜLLER & IVAR ROOTS
Pages: 489-502
Published online: 05 Dec 1999
First Page PreviewforARYLAMINE N-ACETYLTRANSFERASE ACTIVITY IN MAN | Full Text | References | PDF (216.6 KB)
  • 234 Views
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Article
CYTOCHROME P450-BASED CANCER GENE THERAPY: RECENT ADVANCES AND FUTURE PROSPECTS
DAVID J. WAXMAN, LING CHEN, JODI E. D. HECHT & YOUSSEF JOUNAIDI
Pages: 503-522
Published online: 05 Dec 1999
AbstractforCYTOCHROME P450-BASED CANCER GENE THERAPY: RECENT ADVANCES AND FUTURE PROSPECTS | Full Text | References | PDF (338.4 KB)
  • 155 Views
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Article
MERITS AND LIMITATIONS OF RECOMBINANT MODELS FOR THE STUDY OF HUMAN P450-MEDIATED DRUG METABOLISM AND TOXICITY: AN INTRALABORATORY COMPARISON
T. FRIEDBERG, M. P. PRITCHARD, M. BANDERA, S. P. HANLON, D. YAO, L. A. McLAUGHLIN, S. DING, B. BURCHELL & C. R. WOLF
Pages: 523-544
Published online: 05 Dec 1999
AbstractforMERITS AND LIMITATIONS OF RECOMBINANT MODELS FOR THE STUDY OF HUMAN P450-MEDIATED DRUG METABOLISM AND TOXICITY: AN INTRALABORATORY COMPARISON | Full Text | References | PDF (172.6 KB)
  • 131 Views
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Article
EXTRAPOLATING IN VITRO DATA ON DRUG METABOLISM TO IN VIVO PHARMACOKINETICS: EVALUATION OF THE PHARMACOKINETIC INTERACTION BETWEEN AMITRIPTYLINE AND FLUOXETINE
JÜRGEN SCHMIDER, LISA L. VON MOLTKE, RICHARD I. SHADER, JEROLD S. HARMATZ & DAVID J. GREENBLATT
Pages: 545-560
Published online: 05 Dec 1999
AbstractforEXTRAPOLATING IN VITRO DATA ON DRUG METABOLISM TO IN VIVO PHARMACOKINETICS: EVALUATION OF THE PHARMACOKINETIC INTERACTION BETWEEN AMITRIPTYLINE AND FLUOXETINE | Full Text | References | PDF (104.5 KB)
  • 306 Views
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