Expert Opinion on Investigational Drugs, Volume 31, Issue 11 (2022)

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Expert Opinion on Investigational Drugs, Volume 31, Issue 11 (2022)

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Drug Evaluation

Article
Odevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia
Tobias Laue & Ulrich Baumann
Pages: 1143-1150
Published online: 14 Dec 2022
AbstractforOdevixibat: an investigational inhibitor of the ileal bile acid transporter (IBAT) for the treatment of biliary atresia | Full Text | References | PDF (1.5 MB) | EPUB
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Review

Review
Second-line treatment options for hepatocellular carcinoma: current state and challenges for the future
Le Li, Hao-Tian Liu, Yu-Xian Teng, Zhu-Jian Deng, Guan-Lan Zhang, Jia-Yong Su, Liang Ma & Jian-Hong Zhong
Pages: 1151-1167
Published online: 30 Nov 2022
AbstractforSecond-line treatment options for hepatocellular carcinoma: current state and challenges for the future | Full Text | References | PDF (2.5 MB) | EPUB
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Review
Early stage clinical trials for the treatment of hemophilia A
Gianna M Guzzardo, Robert Sidonio, Jr, Michael U Callaghan & Katherine Regling
Pages: 1169-1186
Published online: 09 Nov 2022
AbstractforEarly stage clinical trials for the treatment of hemophilia A | Full Text | References | PDF (1.8 MB) | EPUB
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Review
Next-generation immunotherapy for solid tumors: combination immunotherapy with crosstalk blockade of TGFβ and PD-1/PD-L1
Hue Tu Quach, Zhaohua Hou, Rebecca Y. Bellis, Jasmeen K. Saini, Alfredo Amador-Molina, Prasad S. Adusumilli & Yuquan Xiong
Pages: 1187-1202
Published online: 05 Dec 2022
AbstractforNext-generation immunotherapy for solid tumors: combination immunotherapy with crosstalk blockade of TGFβ and PD-1/PD-L1 | Full Text | References | PDF (3.1 MB) | EPUB
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Review
The triple negative breast cancer drugs graveyard: a review of failed clinical trials 2017-2022
Beatrice Taurelli Salimbeni, Carla Corvaja, Carmine Valenza, Paola Zagami & Giuseppe Curigliano
Pages: 1203-1226
Published online: 22 Dec 2022
AbstractforThe triple negative breast cancer drugs graveyard: a review of failed clinical trials 2017-2022 | Full Text | References | PDF (1.8 MB) | EPUB
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Review
Advances in targeting estrogen synthesis and receptors in patients with endometriosis
Sara Clemenza, Silvia Vannuccini, Agostino Ruotolo, Tommaso Capezzuoli & Felice Petraglia
Pages: 1227-1238
Published online: 18 Dec 2022
AbstractforAdvances in targeting estrogen synthesis and receptors in patients with endometriosis | Full Text | References | PDF (2.1 MB) | EPUB
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Review
What’s the latest with investigational drugs for soft tissue sarcoma?
Elena Cojocaru, Andrea Napolitano, Cyril Fisher, Paul Huang, Robin L Jones & Khin Thway
Pages: 1239-1253
Published online: 05 Dec 2022
AbstractforWhat’s the latest with investigational drugs for soft tissue sarcoma? | Full Text | References | PDF (353.5 KB) | EPUB
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Original Research

Article
The effect of a single escalating dose of long-acting recombinant human follicle-stimulating hormone Fc fusion protein (KN015) on healthy, pituitary-suppressed women: first-in-human and randomized study on its pharmacokinetics, pharmacodynamics, and tolerability
Hong Zhang, Yanyan Fan, Lei Gao, Boguang Wang, Ting Xu, Min Wu, Jingrui Liu, Xiaoxue Zhu, Xiaojiao Li, Hong Chen, Cuiyun Li, Meng Wang, Chengjiao Liu, Yanhong Mao, Mingtang Yang & Yanhua Ding
Pages: 1255-1263
Published online: 20 Dec 2022
AbstractforThe effect of a single escalating dose of long-acting recombinant human follicle-stimulating hormone Fc fusion protein (KN015) on healthy, pituitary-suppressed women: first-in-human and randomized study on its pharmacokinetics, pharmacodynamics, and tolerability | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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