Chemical modifications of artificial restriction DNA cutter (ARCUT) to promote its in vivo and in vitro applications

References

• Chandra M, Sachdeva A, Silverman SK. DNA-catalyzed sequence-specific hydrolysis of DNA. Nat Chem Biol 2009; 5:718-20; PMID:19684594; http://dx.doi.org/10.1038/nchembio.201
   PubMed Web of Science ®Google Scholar
• Aiba Y, Sumaoka J, Komiyama M. Artificial DNA cutters for DNA manipulation and genome engineering. Chem Soc Rev 2011; 40:5657-68; PMID:21566825; http://dx.doi.org/10.1039/c1cs15039a
   PubMed Web of Science ®Google Scholar
• Mancin F, Scrimin P, Tecilla P. Progress in artificial metallonucleases. Chem Commun 2012; 48:5545-59; PMID:22543403; http://dx.doi.org/10.1039/c2cc30952a
   PubMed Web of Science ®Google Scholar
• Komiyama M, Aiba Y, Yamamoto Y, Sumaoka J. Artificial restriction DNA cutter for site-selective scission of double-stranded DNA with tunable scission site and specificity. Nat Protoc 2008; 3:655-62; PMID:18388948; http://dx.doi.org/10.1038/nprot.2008.7
   PubMed Web of Science ®Google Scholar
• Katada H, Komiyama M. Artificial restriction DNA cutters as new tools for gene manipulation. ChemBioChem 2009; 10:1279-88; PMID:19396851; http://dx.doi.org/10.1002/cbic.200900040
   PubMed Web of Science ®Google Scholar
• Komiyama M, Aiba Y, Ishizuka T, Sumaoka J. Solid-phase synthesis of pseudo-complementary peptide nucleic acids. Nat Protoc 2008; 3:646-54; PMID:18388947; http://dx.doi.org/10.1038/nprot.2008.6
   PubMed Web of Science ®Google Scholar
• Egholm M, Buchardt O, Christensen L, Behrens C, Freier SM, Driver DA, Berg RH, Kim SK, Norden B, Nielsen PE. PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules. Nature 1993; 365:566-8; PMID:7692304; http://dx.doi.org/10.1038/365566a0
   PubMed Web of Science ®Google Scholar
• Lohse J, Dahl O, Nielsen PE. Double duplex invasion by peptide nucleic acid: A general principle for sequence-specific targeting of double-stranded DNA. Proc Natl Acad Sci USA 1999; 96:11804-8; PMID:10518531; http://dx.doi.org/10.1073/pnas.96.21.11804
   PubMed Web of Science ®Google Scholar
• Haaima G, Hansen HF, Christensen L, Dahl O, Nielsen PE. Increased DNA binding and sequence discrimination of PNA oligomers containing 2,6-diaminopurine. Nucl Acids Res 1997; 25:4639-43; PMID:9358176; http://dx.doi.org/10.1093/nar/25.22.4639
   PubMed Web of Science ®Google Scholar
• Izvolsky KI, Demidov VV, Nielsen PE, Frank-Kamenetskii MD. Sequence-specific protection of duplex DNA against restriction and methylation enzymes by pseudocomplementary PNAs. Biochemistry 2000; 39:10908-13; PMID:10978178; http://dx.doi.org/10.1021/bi000675e
   PubMed Web of Science ®Google Scholar
• Protozanova E, Demidov VV, Nielsen PE, Frank-Kamenetskii MD. Pseudocomplementary PNAs as selective modifiers of protein activity on duplex DNA: the case of type IIs restriction enzymes. Nucl Acids Res 2003; 31:3929-35; PMID:12853608; http://dx.doi.org/10.1093/nar/gkg450
   PubMed Web of Science ®Google Scholar
• Kuhn H, Cherny DI, Demidov VV, Frank-Kamenetskii MD. Inducing and modulating anisotropic DNA bends by pseudocomplementary peptide nucleic acids. Proc Natl Acad Sci USA 2004; 101:7548-53; PMID:15136738[http://dx.doi.org/10.1073/pnas.0308756101
   PubMed Web of Science ®Google Scholar
• Kitamura Y, Komiyama M. Preferential hydrolysis of gap and bulge sites in DNA by Ce(IV)/EDTA complex. Nucl Acids Res 2002; 30: e102; PMID:12364619; http://dx.doi.org/10.1093/nar/gnf101
   PubMed Web of Science ®Google Scholar
• Ito K, Katada H, Shigi N, Komiyama M. Site-selective scission of human genome by artificial restriction DNA cutter. Chem Commun 2009; 6542-4; PMID:19865643; http://dx.doi.org/10.1039/b911208a
   PubMed Web of Science ®Google Scholar
• Ishizuka T, Xu Y, Komiyama M. A chemistry-based method to detect individual telomere lengths at a single chromosome terminus. J Am Chem Soc 2013;135:14-7; PMID:23252341; http://dx.doi.org/10.1021/ja308481c
   PubMed Web of Science ®Google Scholar
• Katada H, Chen HJ, Shigi N, Komiyama M. Homologous recombination in human cells using artificial restriction DNA cutter. Chem Commun 2009; 6545-7; PMID:19865644; http://dx.doi.org/10.1039/b912030k
   PubMed Web of Science ®Google Scholar
• Katada H, Komiyama M. Artificial Restriction DNA Cutters to Promote Homologous Recombination in Human Cells. Curr Gene Ther 2011; 11:38-45; PMID:21182465; http://dx.doi.org/10.2174/156652311794520094
   PubMed Web of Science ®Google Scholar
• Ito K, Shigi N, Komiyama M. Artificial restriction DNA cutter for site-selective gene insertion in human cells. Chem Commun 2013; 49:6764-6; PMID:23778429; http://dx.doi.org/10.1039/c3cc43261k
   PubMed Web of Science ®Google Scholar
• Nielsen PE. Sequence-selective targeting of duplex DNA by peptide nucleic acids. Curr Opin Mol Ther 2010; 12:184-91; PMID:20373262
   PubMedGoogle Scholar
• Onyshchenko MI, Gaynutdinov TI, Englund EA, Appella DH, Neumann RD, Panyutin IG. Quadruplex formation is necessary for stable PNA invasion into duplex DNA of BCL2 promoter region. Nucl Acids Res 2011; 39:7114-23; PMID:21593130; http://dx.doi.org/10.1093/nar/gkr259
   PubMed Web of Science ®Google Scholar
• Xu Y, Suzuki Y, Lönnberg T, Komiyama M. Human telomeric DNA sequence-specific cleaving by G-quadruplex formation. J Am Chem Soc 2009; 131:2871-4; PMID:19209856; http://dx.doi.org/10.1021/ja807313x
   PubMed Web of Science ®Google Scholar
• Hu J, Corey DR. Inhibiting gene expression with peptide nucleic acid (PNA)-peptide conjugates that target chromosomal DNA. Biochemistry 2007; 46:7581-9; PMID:17536840; http://dx.doi.org/10.1021/bi700230a
   PubMed Web of Science ®Google Scholar
• Bentin T, Hansen GI, Nielsen PE. Structural diversity of target-specific homopyrimidine peptide nucleic acid-dsDNA complexes. Nucl Acids Res 2006; 34:5790-9; PMID:17053099; http://dx.doi.org/10.1093/nar/gkl736
   PubMed Web of Science ®Google Scholar
• Rogers FA, Vasquez KM, Egholm M, Glazer PM. Site-directed recombination via bifunctional PNA–DNA conjugates. Proc Natl Acad Sci USA 2002; 99:16695-700; PMID:12461167; http://dx.doi.org/10.1073/pnas.262556899
   PubMed Web of Science ®Google Scholar
• Vickers TA, Griffith MC, Ramasamy K, Risen LM, Freier SM. Inhibition of NF-κB specific transcriptional activation by PNA strand invasion. Nucl Acids Res 1995; 23:3003-8; PMID:7659524; http://dx.doi.org/10.1093/nar/23.15.3003
   PubMed Web of Science ®Google Scholar
• Demidov VV, Yavnilovich MV, Belotserkovskii BP, Frank-Kamenetskii MD, Nielsen PE. Kinetics and mechanism of polyamide (“peptide”) nucleic acid binding to duplex DNA. Proc Natl Acad Sci USA 1995; 92:2637-41; PMID:7708697; http://dx.doi.org/10.1073/pnas.92.7.2637
   PubMed Web of Science ®Google Scholar
• Boffa LC, Carpaneto EM, Allfrey VG. Isolation of active genes containing CAG repeats by DNA strand invasion by a peptide nucleic acid. Proc Natl Acad Sci USA 1995; 92:1901-5; PMID:7892196; http://dx.doi.org/10.1073/pnas.92.6.1901
   PubMed Web of Science ®Google Scholar
• Ackermann D, Famulok M. Pseudo-complementary PNA actuators as reversible switches in dynamic DNA nanotechnology. Nucl Acids Res 2013; 41:4729-39; PMID:23444144; http://dx.doi.org/10.1093/nar/gkt121
   PubMed Web of Science ®Google Scholar
• Demidov VV, Protozanova E, Izvolsky KI, Price C, Nielsen PE, Frank-Kamenetskii MD. Kinetics and mechanism of the DNA double helix invasion by pseudocomplementary peptide nucleic acids. Proc Natl Acad Sci USA 2002; 99:5953-8; PMID:11972051; http://dx.doi.org/10.1073/pnas.092127999
   PubMed Web of Science ®Google Scholar
• Datta B, Armitage BA. Hybridization of PNA to structured DNA targets:  Quadruplex invasion and the overhang effect. J Am Chem Soc 2001; 123:9612-9; PMID:11572682; http://dx.doi.org/10.1021/ja016204c
   PubMed Web of Science ®Google Scholar
• Zhang X, Ishihara T, Corey DR. Strand invasion by mixed base PNAs and a PNA-peptide chimera. Nucl Acids Res 2000; 28:3332-8; PMID:10954602; http://dx.doi.org/10.1093/nar/28.17.3332
   PubMed Web of Science ®Google Scholar
• Ray A, Nordén B. Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future. FASEB J 2000; 14:1041-60; PMID:10834926
   PubMed Web of Science ®Google Scholar
• Peffer NJ, Hanvey JC, Bisi JE, Thomson SA, Hassman CF, Noble SA, Babiss LE. Strand-invasion of duplex DNA by peptide nucleic acid oligomers. Proc Natl Acad Sci USA 1993; 90:10648-52; PMID:8248156; http://dx.doi.org/10.1073/pnas.90.22.10648
   PubMed Web of Science ®Google Scholar
• Ishizuka T, Yoshida J, Yamamoto Y, Sumaoka J, Tedeschi T, Corradini R, Sforza S, Komiyama M. Chiral introduction of positive charges to PNA for double-duplex invasion to versatile sequences. Nucl Acids Res 2008; 36:1464-71; PMID:18203747; http://dx.doi.org/10.1093/nar/gkm1154
   PubMed Web of Science ®Google Scholar
• Ishizuka T, Yang J, Komiyama M, Xu Y. G-rich sequence-specific recognition and scission of human genome by PNA/DNA hybrid G-quadruplex formation. Angew Chem Int Ed 2012; 51:7198-202; PMID:22700182; http://dx.doi.org/10.1002/anie.201201176
   PubMed Web of Science ®Google Scholar
• Yamazaki T, Aiba Y, Yasuda K, Sakai Y, Yamanaka Y, Kuzuya A, Ohya Y, Komiyama M. Clear-cut observation of PNA invasion using nanomechanical DNA origami devices. Chem Commun 2012; 48:11361-3; PMID:23073563; http://dx.doi.org/10.1039/c2cc36358e
   PubMed Web of Science ®Google Scholar
• Aiba Y, Honda Y, Komiyama M. Promotion of double-duplex invasion of peptide nucleic acid through conjugation with nuclear localization signal peptide. Chem Eur J 2015; 21:4021-6; PMID:25640012; http://dx.doi.org/10.1002/chem.201406085
   PubMed Web of Science ®Google Scholar
• Nielsen PE, Christensen L. Strand displacement binding of a duplex-forming homopurine PNA to a homopyrimidine duplex DNA target. J Am Chem Soc 1996; 118:2287-8; PMID:19306309; http://dx.doi.org/10.1021/ja953125q
   PubMed Web of Science ®Google Scholar
• He G, Rapireddy S, Bahal R, Sahu B, Ly DH. Strand invasion of extended, mixed-sequence B-DNA by γPNAs. J Am Chem Soc 2009; 131:12088-90; PMID:19663424; http://dx.doi.org/10.1021/ja900228j
   PubMed Web of Science ®Google Scholar
• Smolina IV, Demidov VV, Soldatenkov VA, Chasovskikh SG, Frank-Kamenetskii MD. End invasion of peptide nucleic acids (PNAs) with mixed-base composition into linear DNA duplexes. Nucl Acids Res 2005; 33:e146; PMID:16204449; http://dx.doi.org/10.1093/nar/gni151
   PubMedGoogle Scholar
• Rapireddy S, He G, Roy S, Armitage BA, Ly DH. Strand invasion of mixed-sequence B-DNA by acridine-linked, γ-peptide nucleic acid (γ-PNA). J Am Chem Soc 2007; 129:15596-600; PMID:18027941; http://dx.doi.org/10.1021/ja074886j
   PubMed Web of Science ®Google Scholar
• Chenna V, Rapireddy S, Sahu B, Ausin C, Pedroso E, Ly DH. A simple cytosine to G-clamp nucleobase substitution enables chiral γ-PNAs to invade mixed-sequence double-helical B-form DNA. ChemBioChem 2008; 9:2388-91; PMID:18816545; http://dx.doi.org/10.1002/cbic.200800441
   PubMed Web of Science ®Google Scholar
• Branden LJ, Mohamed AJ, Smith CIE. A peptide nucleic acid-nuclear localization signal fusion that mediates nuclear transport of DNA. Nat Biotechnol 1999; 17:784-7; PMID:10429244[http://dx.doi.org/10.1038/11726
   PubMed Web of Science ®Google Scholar
• Cutrona G, Carpaneto EM, Ulivi M, Roncella S, Landt O, Ferrarini M, Boffa LC. Effects in live cells of a c-myc anti-gene PNA linked to a nuclear localization signal. Nat Biotechnol 2000; 18:300-3; PMID:10700145; http://dx.doi.org/10.1038/73745
   PubMed Web of Science ®Google Scholar
• Cogoi S, Codognotto A, Rapozzi V, Meeuwenoord N, van der Marel G, Xodo LE. Transcription inhibition of oncogenic KRAS by a mutation-selective peptide nucleic acid conjugated to the PKKKRKV nuclear localization signal peptide. Biochemistry 2005; 44:10510-9; PMID:16060660; http://dx.doi.org/10.1021/bi0505215
   PubMed Web of Science ®Google Scholar
• Tonelli R, Purgato S, Camerin, C, Fronza R, Bologna F, Alboresi S, Franzoni M, Corradini R, Sforza S, Faccini A, et al. Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis. Mol Cancer Ther 2005; 4:779-86; PMID:15897242; http://dx.doi.org/10.1158/1535-7163.MCT-04-0213
   PubMed Web of Science ®Google Scholar
• Tonelli R, McIntyre A, Camerin C, Walters ZS, Di Leo K, Selfe J, Purgato S, Missiaglia E, Tortori A, Renshaw J, et al. Antitumor activity of sustained N-Myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy. Clin Cancer Res 2012; 18:796-807; PMID:22065083; http://dx.doi.org/10.1158/1078-0432.CCR-11-1981
   PubMed Web of Science ®Google Scholar
• Faccini A, Tortori A, Tedeschi T, Sforza S, Tonelli R, Pession A, Corradini R, Marchelli R. Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against the MYCN oncogene. Chirality 2008; 20:494-500; PMID:17963203; http://dx.doi.org/10.1002/chir.20489
   PubMed Web of Science ®Google Scholar
• Kameshima W, Ishizuka T, Minoshima M, Yamamoto M, Sugiyama H, Xu Y, Komiyama M. Conjugation of peptide nucleic acid with pyrrole–imidazole polyamide to specifically recognize and cleave DNA. Angew Chem Int Ed 2013; 125:13926-9; PMID:24155125; http://dx.doi.org/10.1002/ange.201305489
   PubMed Web of Science ®Google Scholar
• Turner JM, Swalley SE, Baird EE, Dervan PB. Aliphatic/aromatic amino acid pairings for polyamide recognition in the minor groove of DNA. J Am Chem Soc 1998; 120:6219-26; http://dx.doi.org/10.1021/ja980147e
   Web of Science ®Google Scholar
• Dervan PB, Edelson BS. Recognition of the DNA minor groove by pyrrole-imidazole polyamides. Curr Opin Struct Biol 2003; 13:284-99; PMID:12831879; http://dx.doi.org/10.1016/S0959-440X(03)00081-2
   PubMed Web of Science ®Google Scholar
• Bando T, Sugiyama H. Synthesis and biological properties of sequence-specific DNA-alkylating pyrrole−imidazole polyamides. Acc Chem Res 2006; 39:935-44; PMID:17176032; http://dx.doi.org/10.1021/ar030287f
   PubMed Web of Science ®Google Scholar
• Aiba Y, Honda Y, Han Y, Komiyama M. Introduction of multiphosphonate ligand to peptide nucleic acid for metal ion conjugation. Artificial DNA: PNA & XNA 2012; 3:73-9; PMID:22772037; http://dx.doi.org/10.4161/adna.20727
   PubMedGoogle Scholar
• Matsumoto Y, Komiyama M. DNA hydrolysis by rare earth metal ions. Chem Exp 1992; 7:785-8
   Google Scholar
• Sumaoka J, Yashiro M, Komiyama M. Remarkably fast hydrolysis of 3′,5′-cyclic adenosine mono-phosphate by cerium(III) hydroxide cluster. Chem Commun 1992; 1707-8; http://dx.doi.org/10.1039/c39920001707
   Web of Science ®Google Scholar
• Komiyama M, Kodama T, Takeda N, Sumaoka J, Shiiba T, Matsumoto Y, Yashiro M. Catalytically active species for the CeCl3-induced DNA hydrolysis. J Biochem 1994; 115:809-10; PMID:7961589
   PubMed Web of Science ®Google Scholar
• Takasaki BK, Chin J. Cleavage of the phosphate diester backbone of DNA with cerium(III) and molecular oxygen. J Am Chem Soc 1994; 116:1121-2; http://dx.doi.org/10.1021/ja00082a040
   Web of Science ®Google Scholar
• Komiyama M, Shiiba T, Kodama T, Takeda N, Sumaoka J, Yashiro M. DNA hydrolysis by cerium(IV) does not involve either molecular oxygen or hydrogen peroxide. Chem Lett 1994; 23:1025-8; http://dx.doi.org/10.1246/cl.1994.1025
   Web of Science ®Google Scholar
• Lönnberg T, Aiba Y, Hamano Y, Miyajima Y, Sumaoka J, Komiyama M. Oxidation of an oligonucleotide-bound Ce(III)/multiphosphonate complex for site-selective DNA scission. Chem Eur J 2010; 16:855-9; PMID:19938010; http://dx.doi.org/10.1002/chem.200902169
   PubMed Web of Science ®Google Scholar
• Aiba Y, Hamano Y, Kameshima W, Araki Y, Wada T, Accetta A, Sforza S, Corradini R, Marchelli R, Komiyama M. Conjugate of peptide nucleic acid and nuclear localization signal as single-molecular activator of target site in double-stranded DNA for site-selective scission. Org Biomol Chem 2013; 11:5233-8; PMID:23820872; http://dx.doi.org/10.1039/c3ob40947c
   PubMed Web of Science ®Google Scholar
• Lahoud G, Timoshchuk V, Lebedev A, Arar K, Hou YM, Gamper H. Properties of pseudo-complementary DNA substituted with weakly pairing analogs of guanine or cytosine. Nucl Acids Res 2008; 36:6999-7008; PMID:18987000; http://dx.doi.org/10.1093/nar/gkn797
   PubMed Web of Science ®Google Scholar
• Hoshika S, Chen F, Leal NA, Benner SA. Artificial genetic systems: Self-avoiding DNA in PCR and multiplexed PCR. Angew Chem Int Ed 2010; 49:5554-7; PMID:20586087; http://dx.doi.org/10.1002/anie.201001977
   PubMed Web of Science ®Google Scholar
• Olsen AG, Dahl O, Petersen AB, Nielsen J, Nielsen PE. A novel pseudo-complementary PNA G-C base pair. Artificial DNA: PNA & XNA 2011; 2:32-6; PMID:21686250; http://dx.doi.org/10.4161/adna.2.1.15554
   PubMedGoogle Scholar
• Miyajima Y, Ishizuka T, Yamamoto Y, Sumaoka J, Komiyama M. Origin of high fidelity in target-sequence recognition by PNA-Ce(IV)/EDTA combination as site-selective DNA cutter. J Am Chem Soc 2009; 131:2657-62; PMID:19199631; http://dx.doi.org/10.1021/ja808290e
   PubMed Web of Science ®Google Scholar
• Harvey BJ, Levitus M. Nucleobase-specific enhancement of Cy3 fluorescence. J Fluoresc 2009; 19:443-8; PMID:18972191; http://dx.doi.org/10.1007/s10895-008-0431-1
   PubMed Web of Science ®Google Scholar
• Aiba Y, Yasuda K, Komiyama M. Site-selective scission of double-stranded DNA by combining a triplex-forming bis-PNA and Ce(IV)/EDTA. Chem Lett 2013; 42:1300-2; http://dx.doi.org/10.1246/cl.130650
   Web of Science ®Google Scholar
• Buske FA, Mattick JS, Bailey TL. Potential in vivo roles of nucleic acid triple-helices. RNA Biol 2011; 8:427-39; PMID:21525785; http://dx.doi.org/10.4161/rna.8.3.14999
   PubMed Web of Science ®Google Scholar
• Mirkin SM. Expandable DNA repeats and human disease. Nature 2007; 447:932-40; PMID:17581576; http://dx.doi.org/10.1038/nature05977
   PubMed Web of Science ®Google Scholar
• Dey I, Rath PC. A novel rat genomic simple repeat DNA with RNA-homology shows triplex (H-DNA)-like structure and tissue-specific RNA expression. Biochem Biophys Res Commun 2005; 327:276-86; PMID:15629459; http://dx.doi.org/10.1016/j.bbrc.2004.12.015
   PubMed Web of Science ®Google Scholar
• Belotserkovskii BP, Liu R, Tornaletti S, Krasilnikova MM, Mirkin SM, Hanawalt PC. Mechanisms and implications of transcription blockage by guanine-rich DNA sequences. Proc Natl Acad Sci USA 2010; 107:12816-21; PMID:20616059; http://dx.doi.org/10.1073/pnas.1007580107
   PubMed Web of Science ®Google Scholar
• Belotserkovskii BP, Neil AJ, Saleh SS, Shin JHS, Mirkin SM, Hanawalt PC. Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks. Nucl Acids Res 2013; 41:1817-28; PMID:23275544; http://dx.doi.org/10.1093/nar/gks1333
   PubMed Web of Science ®Google Scholar
• Egholm M, Christensen L, Deuholm KL, Buchardt O, Coull J, Nielsen PE. Efficient pH-independent sequence-specific DNA binding by pseudoisocytosine-containing bis-PNA. Nucl Acids Res 1995; 23:217-22; PMID:7862524; http://dx.doi.org/10.1093/nar/23.2.217
   PubMed Web of Science ®Google Scholar
• Griffith MC, Risen LM, Greig MJ, Lesnik EA, Sprankle KG, Griffey RH, Kiely JS, Freier SM. Single and bis peptide nucleic acids as triplexing agents: Binding and stoichiometry. J Am Chem Soc 1995; 117:831-2; http://dx.doi.org/10.1021/ja00107a033
   Web of Science ®Google Scholar
• Sumaoka J, Komiyama M. Molecular crowding facilitates double-duplex invasion of pseudo-complementary peptide nucleic acid in high salt medium. Chem Lett 2014; 43:1581-3; http://dx.doi.org/10.1246/cl.140620
   Web of Science ®Google Scholar
• Lonkar P, Kim KH, Kuan JY, Chin JY, Rogers FA, Knauert MP, Kole R, Nielsen PE, Glazer PM. Targeted correction of a thalassemia-associated b-globin mutation induced by pseudo-complementary peptide nucleic acids. Nucl Acids Res 2009; 37:3635-44; PMID:19364810; http://dx.doi.org/10.1093/nar/gkp217
   PubMed Web of Science ®Google Scholar
• Fulton AB. How crowded is the cytoplasm? Cell 1982; 30:345-7; PMID:6754085; http://dx.doi.org/10.1016/0092-8674(82)90231-8
   PubMed Web of Science ®Google Scholar
• Zimmerman SB, Trach SO. Estimation of macromolecule concentrations and excluded volume effects for the cytoplasm of Escherichia coli. J Mol Biol 1991; 222:599-620; PMID:1748995; http://dx.doi.org/10.1016/0022-2836(91)90499-V
   PubMed Web of Science ®Google Scholar
• Miyoshi D, Sugimoto N. Molecular crowding effects on structure and stability of DNA. Biochimie 2008; 90:1040-51; PMID:18331845; http://dx.doi.org/10.1016/j.biochi.2008.02.009
   PubMed Web of Science ®Google Scholar
• Markarian MZ, Schlenoff JB. Effect of molecular crowding and ionic strength on the isothermal hybridization of oligonucleotides. J Phys Chem B 2010; 114:10620-7; PMID:20701389; http://dx.doi.org/10.1021/jp103213w
   PubMed Web of Science ®Google Scholar
• Miyoshi D, Nakamura K, Tateishi-Karimata H, Ohmichi T, Sugimoto N. Hydration of Watson−Crick base pairs and dehydration of Hoogsteen base pairs inducing structural polymorphism under molecular crowding conditions. J Am Chem Soc 2009; 131:3522-31; PMID:19236045; http://dx.doi.org/10.1021/ja805972a
   PubMed Web of Science ®Google Scholar
• Nakano S, Yamaguchi D, Tateishi-Karimata H, Miyoshi D, Sugimoto N. Hydration changes upon DNA folding studied by osmotic stress experiments. Biophys J 2012; 102:2808-17; PMID:22735531; http://dx.doi.org/10.1016/j.bpj.2012.05.019
   PubMed Web of Science ®Google Scholar
• Kim YG, Cha J, Chandrasegaran S. Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc Natl Acad Sci USA 1996; 93:1156-60; PMID:8577732; http://dx.doi.org/10.1073/pnas.93.3.1156
   PubMed Web of Science ®Google Scholar
• Christian M, Cermak T, Doyle EL, Schmidt C, Zhang F, Hummel A, Bogdanove AJ, Voytas DF. Targeting DNA double-strand breaks with TAL effector nucleases. Genetics 2010; 186:757-61; PMID:20660643; http://dx.doi.org/10.1534/genetics.110.120717
   PubMed Web of Science ®Google Scholar
• Mussolino C, Morbitzer R, Lütge F, Dannemann N, Lahaye T, Cathomen T. A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucl Acids Res 2011; 39:9283-93; PMID:21813459; http://dx.doi.org/10.1093/nar/gkr597
   PubMed Web of Science ®Google Scholar
• Stoddard BL. Homing endonuclease structure and function. Q Rev Biophys 2005; 38:49-95; PMID:16336743; http://dx.doi.org/10.1017/S0033583505004063
   PubMed Web of Science ®Google Scholar
• Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F. Multiplex genome engineering using CRISPR/Cas systems. Science 2013; 339:819-23; PMID:23287718; http://dx.doi.org/10.1126/science.1231143
   PubMed Web of Science ®Google Scholar
• Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM. RNA-guided human genome engineering via Cas9. Science 2013; 339:823-6; PMID:23287722; http://dx.doi.org/10.1126/science.1232033
   PubMed Web of Science ®Google Scholar