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Volume 4, Issue 8

Expert Opinion on Drug Discovery

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Expert Opinion on Drug Discovery, Volume 4, Issue 8 (2009)

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Expert Opinion on Drug Discovery, Volume 4, Issue 8 (2009)

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Article

Implications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins

Donavon C Hiss MSc (Med) PhD (Med) & Gary A Gabriels MSc (Med)

Pages: 799-821

Published online: 10 Jun 2009

AbstractforImplications of endoplasmic reticulum stress, the unfolded protein response and apoptosis for molecular cancer therapy. Part I: targeting p53, Mdm2, GADD153/CHOP, GRP78/BiP and heat shock proteins | Full Text | References | PDF (705 KB)

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Article

Design of small molecules targeting transcriptional activation by NF-κB: overview of recent advances

Daniel S Straus

Pages: 823-836

Published online: 22 Jul 2009

AbstractforDesign of small molecules targeting transcriptional activation by NF-κB: overview of recent advances | Full Text | References | PDF (746 KB)

124 Views
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Article

Model-based approaches to increase efficiency of drug development in schizophrenia: a can't miss opportunity

Gianluca Nucci, Roberto Gomeni & Italo Poggesi

Pages: 837-856

Published online: 24 Jun 2009

AbstractforModel-based approaches to increase efficiency of drug development in schizophrenia: a can't miss opportunity | Full Text | References | PDF (1 MB)

218 Views
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Article

Drug target central

Lee Harland & Anna Gaulton

Pages: 857-872

Published online: 22 Jul 2009

AbstractforDrug target central | Full Text | References | PDF (1.8 MB)

237 Views
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Article

The impact of hardware improvement for molecular modeling in a grid environment

Dandan Li, Ming Sun, Mingxiao Li, Zhibin Li & Zhenran Jiang

Pages: 873-877

Published online: 23 Jun 2009

AbstractforThe impact of hardware improvement for molecular modeling in a grid environment | Full Text | References | PDF (634.3 KB)

29 Views
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Article

The role of murine models of prostate cancer in drug target discovery and validation

Imran Ahmad, Owen J Sansom & Hing Y Leung

Pages: 879-888

Published online: 22 Jul 2009

AbstractforThe role of murine models of prostate cancer in drug target discovery and validation | Full Text | References | PDF (1.2 MB)

102 Views
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Article

Applications of fiber-optics-based nanosensors to drug discovery

Tuan Vo-Dinh, Jonathan Scaffidi, Molly Gregas, Yan Zhang & Victoria Seewaldt

Pages: 889-900

Published online: 22 Jul 2009

AbstractforApplications of fiber-optics-based nanosensors to drug discovery | Full Text | References | PDF (2.7 MB)

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