Virulence, Volume 12, Issue 1 (2021)

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Virulence, Volume 12, Issue 1 (2021)

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Research Paper

Article
The novel outer membrane protein from OprD/Occ family is associated with hypervirulence of carbapenem resistant Acinetobacter baumannii ST2/KL22
Mingxi Hua, Jingyuan Liu, Pengcheng Du, Xinzhe Liu, Min Li, Huizhu Wang, Chen Chen, Xinmin Xu, Yu Jiang, Yajie Wang, Hui Zeng & Ang Li
Pages: 1-11
Published online: 29 Dec 2020
AbstractforThe novel outer membrane protein from OprD/Occ family is associated with hypervirulence of carbapenem resistant Acinetobacter baumannii ST2/KL22 | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Open Access
Article
Cross-protective immunity of the haemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice
Han Lei, Tong Gao & Qianhong Cen
Pages: 12-19
Published online: 29 Dec 2020
AbstractforCross-protective immunity of the haemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice | Full Text | References | PDF (1.3 MB) | EPUB
  • 2484 Views
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Article
Comprehensive analysis of lncRNA expression profiles in cytopathic biotype BVDV-infected MDBK cells provides an insight into biological contexts of host–BVDV interactions
Xuwen Gao, Chao Niu, Zhuo Wang, Shuo Jia, Meijing Han, Yingying Ma, Xueting Guan, Li Wang, Xinyuan Qiao & Yigang Xu
Pages: 20-34
Published online: 29 Dec 2020
AbstractforComprehensive analysis of lncRNA expression profiles in cytopathic biotype BVDV-infected MDBK cells provides an insight into biological contexts of host–BVDV interactions | Full Text | References | PDF (12.6 MB) | EPUB | Supplemental
  • 3193 Views
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Open Access
Article
Hypervirulent and hypermucoviscous extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Klebsiella variicola in Chile
F. Morales-León, A. Opazo-Capurro, C. Caro, N. Lincopan, A. Cardenas-Arias, F. Esposito, V. Illesca, M. L. Rioseco, M. Domínguez-Yévenes, C. A. Lima, H. Bello-Toledo & Gerardo González-Rocha
Pages: 35-44
Published online: 29 Dec 2020
AbstractforHypervirulent and hypermucoviscous extended-spectrum β-lactamase-producing Klebsiella pneumoniae and Klebsiella variicola in Chile | Full Text | References | PDF (1.2 MB) | EPUB
  • 4304 Views
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Open Access
Article
gga-miR-1603 and gga-miR-1794 directly target viral L gene and function as a broad-spectrum antiviral factor against NDV replication
Yu Chen, Shanshan Zhu, Jiao Hu, Zenglei Hu, Xiaowen Liu, Xiaoquan Wang, Min Gu, Shunlin Hu & Xiufan Liu
Pages: 45-56
Published online: 29 Dec 2020
Abstractforgga-miR-1603 and gga-miR-1794 directly target viral L gene and function as a broad-spectrum antiviral factor against NDV replication | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 2016 Views
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Open Access
Article
Antimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences
Radwa Abdelwahab, Muhammad Yasir, Rita E. Godfrey, Gabrielle S. Christie, Sarah J. Element, Faye Saville, Ehsan A. Hassan, Entsar H. Ahmed, Nagla H. Abu-Faddan, Enas A. Daef, Stephen J. W. Busby & Douglas F. Browning
Pages: 57-74
Published online: 29 Dec 2020
AbstractforAntimicrobial resistance and gene regulation in Enteroaggregative Escherichia coli from Egyptian children with diarrhoea: Similarities and differences | Full Text | References | PDF (5.2 MB) | EPUB | Supplemental
  • 3445 Views
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Open Access
Article
Defective apoptotic cell clearance activates innate immune response to protect Caenorhabditis elegans against pathogenic bacteria
Jinlong Wan, Lei Yuan, Huiru Jing, Qian Zheng & Hui Xiao
Pages: 75-83
Published online: 29 Dec 2020
AbstractforDefective apoptotic cell clearance activates innate immune response to protect Caenorhabditis elegans against pathogenic bacteria | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 3079 Views
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Open Access
Article
Bordetella bronchiseptica promotes adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model
Désirée Vötsch, Maren Willenborg, Wolfgang Baumgärtner, Manfred Rohde & Peter Valentin-Weigand
Pages: 84-95
Published online: 29 Dec 2020
AbstractforBordetella bronchiseptica promotes adherence, colonization, and cytotoxicity of Streptococcus suis in a porcine precision-cut lung slice model | Full Text | References | PDF (4.8 MB) | EPUB | Supplemental
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Article
A novel phosphoinositide kinase Fab1 regulates biosynthesis of pathogenic aflatoxin in Aspergillus flavus
Mingkun Yang, Zhuo Zhu, Youhuang Bai, Zhenhong Zhuang, Feng Ge, Mingzhu Li & Shihua Wang
Pages: 96-113
Published online: 29 Dec 2020
AbstractforA novel phosphoinositide kinase Fab1 regulates biosynthesis of pathogenic aflatoxin in Aspergillus flavus | Full Text | References | PDF (10.9 MB) | EPUB | Supplemental
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Open Access

Review Article

Review Article
A systematic review of the epidemiology of Hepatitis E virus infection in South – Eastern Asia
Yakubu Egigogo Raji, Ooi Peck Toung, Niazlin Mohd Taib & Zamberi Bin Sekawi
Pages: 114-129
Published online: 29 Dec 2020
AbstractforA systematic review of the epidemiology of Hepatitis E virus infection in South – Eastern Asia | Full Text | References | PDF (783.9 KB) | EPUB | Supplemental
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Open Access

Research Paper

Article
Classical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells.
Erpeng Zhu, Huawei Wu, Wenxian Chen, Yuwei Qin, Jiameng Liu, Shuangqi Fan, Shengming Ma, Keke Wu, Qian Mao, Chaowei Luo, Yixian Qin, Lin Yi, Hongxing Ding, Mingqiu Zhao & Jinding Chen
Pages: 130-149
Published online: 31 Dec 2020
AbstractforClassical swine fever virus employs the PERK- and IRE1-dependent autophagy for viral replication in cultured cells. | Full Text | References | PDF (7.9 MB) | EPUB
  • 3178 Views
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Open Access
Article
Genomic and phenotypic analyses of multidrug-resistant Acinetobacter baumannii NCCP 16007 isolated from a patient with a urinary tract infection
Misung Kim, Jaeeun Park & Woojun Park
Pages: 150-164
Published online: 29 Dec 2020
AbstractforGenomic and phenotypic analyses of multidrug-resistant Acinetobacter baumannii NCCP 16007 isolated from a patient with a urinary tract infection | Full Text | References | PDF (7.6 MB) | EPUB | Supplemental
  • 3673 Views
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Open Access
Article
Luteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin
Jing Dong, Lushan Zhang, Yongtao Liu, Ning Xu, Shun Zhou, Yibin Yang, Qiuhong Yang & Xiaohui Ai
Pages: 165-176
Published online: 29 Dec 2020
AbstractforLuteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin | Full Text | References | PDF (6.6 MB) | EPUB | Supplemental
  • 2594 Views
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Open Access
Article
Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV)
Ang Su, Yuguang Fu, Jochen Meens, Wei Yang, Fandan Meng, Georg Herrler & Paul Becher
Pages: 177-187
Published online: 04 Jan 2021
AbstractforInfection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV) | Full Text | References | PDF (7.1 MB) | EPUB
  • 2916 Views
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Open Access
Article
Preparation and functional evaluation of monoclonal antibodies targeting Hepatitis B Virus Polymerase
Song Hu, Hualong Xiong, Xiaozhen Kang, Shaojuan Wang, Tianying Zhang, Quan Yuan & Deying Tian
Pages: 188-194
Published online: 18 Jan 2021
AbstractforPreparation and functional evaluation of monoclonal antibodies targeting Hepatitis B Virus Polymerase | Full Text | References | PDF (2.9 MB) | EPUB
  • 2210 Views
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Open Access

Review

Review Article
Lipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria
Ritika Chatterjee, Atish Roy Chowdhury, Debapriya Mukherjee & Dipshikha Chakravortty
Pages: 195-216
Published online: 08 Jan 2021
AbstractforLipid larceny: channelizing host lipids for establishing successful pathogenesis by bacteria | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 4328 Views
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Research Paper

Article
Mangiferin enhances the antifungal activities of caspofungin by destroying polyamine accumulation
Juan Shen, RenYi Lu, Qing Cai, LingZhi Fan, WanNian Yan, ZhenYu Zhu, LianJuan Yang & YingYing Cao
Pages: 217-230
Published online: 06 Jan 2021
AbstractforMangiferin enhances the antifungal activities of caspofungin by destroying polyamine accumulation | Full Text | References | PDF (4.4 MB) | EPUB
  • 2082 Views
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Open Access
Article
Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella
Yuliana Vega-Chacón, Maria Carolina de Albuquerque, Ana Cláudia Pavarina, Gustavo Henrique Goldman & Ewerton Garcia de Oliveira Mima
Pages: 231-243
Published online: 07 Jan 2021
AbstractforVerapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Open Access
Article
Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain
Rebeca Froes Rocha, Juliana L. Del Sarto, Giovanni F. Gomes, Mariana P. Gonçalves, Milene A. Rachid, Juliana H. C. Smetana, Daniele G. Souza, Mauro Martins Teixeira & Rafael Elias Marques
Pages: 244-259
Published online: 07 Jan 2021
AbstractforType I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain | Full Text | References | PDF (12.1 MB) | EPUB | Supplemental
  • 1987 Views
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Open Access
Article
Methicillin-resistant Staphylococcus aureus from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis
Fernanda Sampaio Cavalcante, Simone Saintive, Dennis Carvalho Ferreira, Adriana Barbosa Rocha Silva, Lorrayne Cardoso Guimarães, Beatriz Stofel Braga, Eliane de Dios Abad, Marcia Ribeiro & Kátia Regina Netto dos Santos
Pages: 260-269
Published online: 07 Jan 2021
AbstractforMethicillin-resistant Staphylococcus aureus from infected skin lesions present several virulence genes and are associated with the CC30 in Brazilian children with atopic dermatitis | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 2854 Views
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Open Access
Article
Accelerated cardiovascular risk after viral clearance in hepatitis C patients with the NAMPT-rs61330082 TT genotype: An 8-year prospective cohort study
Ming-Ling Chang, Yu-Sheng Lin, Ming-Yu Chang, Chia-Lin Hsu, Rong-Nan Chien & Cathy SJ Fann
Pages: 270-280
Published online: 15 Jan 2021
AbstractforAccelerated cardiovascular risk after viral clearance in hepatitis C patients with the NAMPT-rs61330082 TT genotype: An 8-year prospective cohort study | Full Text | References | PDF (5.8 MB) | EPUB | Supplemental
  • 2897 Views
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Open Access
Article
MSS2 maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in Candida albicans
Cai-Ling Ke, Yu-Ting Liao & Ching-Hsuan Lin
Pages: 281-297
Published online: 11 Jan 2021
AbstractforMSS2 maintains mitochondrial function and is required for chitosan resistance, invasive growth, biofilm formation and virulence in Candida albicans | Full Text | References | PDF (7.6 MB) | EPUB | Supplemental
  • 2559 Views
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Open Access
Article
Downregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity of Salmonella Typhimurium
Shuangshuang Ma, Lingyan Jiang, Jingting Wang, Xiaoqian Liu, Wanwu Li, Shuai Ma & Lu Feng
Pages: 298-311
Published online: 07 Jan 2021
AbstractforDownregulation of a novel flagellar synthesis regulator AsiR promotes intracellular replication and systemic pathogenicity of Salmonella Typhimurium | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2220 Views
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Open Access
Article
Post-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival
Yanqing Bao, Lin Wang & Jianjun Sun
Pages: 312-328
Published online: 11 Jan 2021
AbstractforPost-translational knockdown and post-secretional modification of EsxA determine contribution of EsxA membrane permeabilizing activity for mycobacterial intracellular survival | Full Text | References | PDF (6 MB) | EPUB | Supplemental
  • 2038 Views
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Open Access
Article
The involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization
Mieke Van Ende, Bea Timmermans, Giel Vanreppelen, Sofía Siscar-Lewin, Daniel Fischer, Stefanie Wijnants, Celia Lobo Romero, Saleh Yazdani, Ona Rogiers, Liesbeth Demuyser, Griet Van Zeebroeck, Yuke Cen, Karl Kuchler, Sascha Brunke & Patrick Van Dijck
Pages: 329-345
Published online: 12 Jan 2021
AbstractforThe involvement of the Candida glabrata trehalase enzymes in stress resistance and gut colonization | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 3043 Views
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Open Access
Article
The Superior Adherence Phenotype of E. coli O104:H4 is Directly Mediated by the Aggregative Adherence Fimbriae Type I
Philipp Schiller, Michael Knödler, Petya Berger, Lilo Greune, Angelika Fruth, Alexander Mellmann, Petra Dersch, Michael Berger & Ulrich Dobrindt
Pages: 346-359
Published online: 15 Jan 2021
AbstractforThe Superior Adherence Phenotype of E. coli O104:H4 is Directly Mediated by the Aggregative Adherence Fimbriae Type I | Full Text | References | PDF (8.5 MB) | EPUB | Supplemental
  • 2225 Views
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Open Access
Article
Vagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis
Li Yue-Chun, Xiao-Hong Gu, Ge Li-Sha, De-Pu Zhou, Chao Xing, Xiao-Ling Guo, Lu-Lu Pan, Shi-Yang Song, Li-Li Yu, Guang-Yi Chen, Jia-Feng Lin & Mao-Ping Chu
Pages: 360-376
Published online: 15 Jan 2021
AbstractforVagus nerve plays a pivotal role in CD4+ T cell differentiation during CVB3-induced murine acute myocarditis | Full Text | References | PDF (16.6 MB) | EPUB | Supplemental
  • 3708 Views
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Open Access
Article
Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study
Ping Li, Qiqiang Liang, Wugao Liu, Beiwen Zheng, Lizhang Liu, Wei Wang, Zhijiang Xu, Man Huang & Youjun Feng
Pages: 377-388
Published online: 18 Jan 2021
AbstractforConvergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 3191 Views
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Open Access
Article
Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3
Christian Spoerry, Jens Karlsson, Marie-Stephanie Aschtgen & Edmund Loh
Pages: 389-403
Published online: 18 Jan 2021
AbstractforNeisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3 | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
  • 2942 Views
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Open Access
Article
Isolation, identification, and phylogenetic analysis of subgroup III strain of bovine respiratory syncytial virus contributed to outbreak of acute respiratory disease among cattle in Northeast China
Shuo Jia, Xin Yao, Yaqi Yang, Chao Niu, Yi Zhao, Xiaomei Zhang, Ronghui Pan, Xiaoxia Jiang, Sun Xiaobo, Xinyuan Qiao, Xueting Guan & Yigang Xu
Pages: 404-414
Published online: 20 Jan 2021
AbstractforIsolation, identification, and phylogenetic analysis of subgroup III strain of bovine respiratory syncytial virus contributed to outbreak of acute respiratory disease among cattle in Northeast China | Full Text | References | PDF (2.3 MB) | EPUB
  • 2504 Views
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Open Access
Article
The lipoprotein NlpD in Cronobacter sakazakii responds to acid stress and regulates macrophage resistance and virulence by maintaining membrane integrity
Running Title: Identification and characterization of a novel factor involved in acid tolerance and virulence in Cronobacter sakazakii
Xuemeng Ji, Ping Lu, Juan Xue, Ning Zhao, Yan Zhang, Lu Dong, Xuejiao Zhang, Ping Li, Yaozhong Hu, Jin Wang, Bowei Zhang, Jingmin Liu, Huan lv & Shuo Wang
Pages: 415-429
Published online: 18 Jan 2021
AbstractforThe lipoprotein NlpD in Cronobacter sakazakii responds to acid stress and regulates macrophage resistance and virulence by maintaining membrane integrity | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2379 Views
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Open Access
Article
Toll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection
Venezuelan equine encephalitis virus and toll-like receptor 4
Bradley S. Hollidge, Courtney A. Cohen, Justice Akuoku Frimpong, Catherine V. Badger, John M. Dye & Connie S. Schmaljohn
Pages: 430-443
Published online: 25 Jan 2021
AbstractforToll-like receptor 4 mediates blood-brain barrier permeability and disease in C3H mice during Venezuelan equine encephalitis virus infection | Full Text | References | PDF (627.2 KB) | EPUB
  • 2850 Views
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Review Article

Review Article
Host Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses
Jiarui Li & Ester Boix
Pages: 444-469
Published online: 04 Mar 2021
AbstractforHost Defence RNases as Antiviral Agents against Enveloped Single Stranded RNA Viruses | Full Text | References | PDF (1.6 MB) | EPUB
  • 4189 Views
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Research Paper

Article
YjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus
Atmika Paudel, Suresh Panthee, Hiroshi Hamamoto, Tom Grunert & Kazuhisa Sekimizu
Pages: 470-480
Published online: 25 Jan 2021
AbstractforYjbH regulates virulence genes expression and oxidative stress resistance in Staphylococcus aureus | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 3285 Views
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Open Access
Article
The PirB toxin protein from Vibrio parahaemolyticus induces apoptosis in hemocytes of Penaeus vannamei
PirB induces shrimp hemocytes apoptosis
Zhou Zheng, Ruiwei Li, Jude Juventus Aweya, Defu Yao, Fan Wang, Shengkang Li, Tran Ngoc Tuan & Yueling Zhang
Pages: 481-492
Published online: 25 Jan 2021
AbstractforThe PirB toxin protein from Vibrio parahaemolyticus induces apoptosis in hemocytes of Penaeus vannamei | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3773 Views
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Open Access
Article
A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections
Guanbo Wang, Lena Glaser, Nichollas E. Scott, Yasmine Fathy Mohamed, Rebecca Ingram, Karine Laroucau & Miguel A. Valvano
Pages: 493-506
Published online: 28 Jan 2021
AbstractforA glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections | Full Text | References | PDF (8.6 MB) | EPUB | Supplemental
  • 1990 Views
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Open Access

Editorial

Editorial
COVID-19 evolution during the pandemic – Implications of new SARS-CoV-2 variants on disease control and public health policies
Cock van Oosterhout, Neil Hall, Hinh Ly & Kevin M. Tyler
Pages: 507-508
Published online: 25 Jan 2021
CitationforCOVID-19 evolution during the pandemic – Implications of new SARS-CoV-2 variants on disease control and public health policies | Full Text | References | PDF (190.3 KB) | EPUB
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Research Paper

Article
Autophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells
Xiaoyue Hou, Lu Han, Baoju An & Jun Cai
Pages: 509-519
Published online: 28 Jan 2021
AbstractforAutophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2026 Views
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Open Access
Article
Deletion of Polyamine Transport Protein PotD Exacerbates Virulence in Glaesserella (Haemophilus) parasuis in the Form of Non-biofilm-generated Bacteria in a Murine Acute Infection Model
Ke Dai, Zhen Yang, Xiaoyu Ma, Yung-Fu Chang, Sanjie Cao, Qin Zhao, Xiaobo Huang, Rui Wu, Yong Huang, Jing Xia, Qigui Yan, Xinfeng Han, Xiaoping Ma, Xintian Wen & Yiping Wen
Pages: 520-546
Published online: 02 Feb 2021
AbstractforDeletion of Polyamine Transport Protein PotD Exacerbates Virulence in Glaesserella (Haemophilus) parasuis in the Form of Non-biofilm-generated Bacteria in a Murine Acute Infection Model | Full Text | References | PDF (7.7 MB) | EPUB | Supplemental
  • 2156 Views
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Review

Review
Pathogenicity and virulence of Staphylococcus aureus
Gordon Y. C. Cheung, Justin S. Bae & Michael Otto
Pages: 547-569
Published online: 31 Jan 2021
AbstractforPathogenicity and virulence of Staphylococcus aureus | Full Text | References | PDF (2 MB) | EPUB
  • 75986 Views
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Research Paper

Article
TREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis
L Bernal-Martínez, SM Gonçalves, B de Andres, C Cunha, I Gonzalez Jimenez, K Lagrou, E Mellado, ML Gaspar, JA Maertens, A Carvalho & L Alcazar-Fuoli
Pages: 570-583
Published online: 02 Feb 2021
AbstractforTREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 2511 Views
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Article
Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of Staphylococcus aureus LAC and UAMS-1
Joseph S. Rom, Karen E. Beenken, Aura M. Ramirez, Christopher M. Walker, Ethan J. Echols & Mark S. Smeltzer
Pages: 584-600
Published online: 04 Feb 2021
AbstractforLimiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of Staphylococcus aureus LAC and UAMS-1 | Full Text | References | PDF (2.1 MB) | EPUB
  • 2047 Views
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Article
The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes
Joana Branco, Cláudia Martins-Cruz, Lisa Rodrigues, Raquel M. Silva, Nuno Araújo-Gomes, Teresa Gonçalves, Isabel M. Miranda & Acácio G. Rodrigues
Pages: 601-614
Published online: 04 Feb 2021
AbstractforThe transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2476 Views
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Article
Dynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking
Wei Hou, Wenjie Kang, Yangyang Li, Yanke Shan, Shouyu Wang & Fei Liu
Pages: 615-629
Published online: 04 Feb 2021
AbstractforDynamic Dissection of Dynein and Kinesin-1 Cooperatively Mediated Intercellular Transport of Porcine Epidemic Diarrhea Coronavirus along Microtubule Using Single Virus Tracking | Full Text | References | PDF (8.9 MB) | EPUB | Supplemental
  • 3198 Views
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Article
Norepinephrine affects the interaction of adherent-invasive Escherichia coli with intestinal epithelial cells
Sobieszczańska Beata, Turniak Michał, Olbromski Mateusz, Walczuk Urszula, Marcin Choroszy, Tukiendorf Andrzej & Dzięgiel Piotr
Pages: 630-637
Published online: 04 Feb 2021
AbstractforNorepinephrine affects the interaction of adherent-invasive Escherichia coli with intestinal epithelial cells | Full Text | References | PDF (883.3 KB) | EPUB | Supplemental
  • 2017 Views
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Article
Defective phagocyte association during infection of Galleria mellonella with Yersinia pseudotuberculosis is detrimental to both insect host and microbe
Anne Marie Krachler, Natalie Sirisaengtaksin, Pauline Monteith, C. E. Timothy Paine, Christopher J. Coates & Jenson Lim
Pages: 638-653
Published online: 08 Feb 2021
AbstractforDefective phagocyte association during infection of Galleria mellonella with Yersinia pseudotuberculosis is detrimental to both insect host and microbe | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 2094 Views
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Article
Disruption of interferon-β production by the Npro of atypical porcine pestivirus
Chunxiao Mou, Shuonan Pan, Huiguang Wu & Zhenhai Chen
Pages: 654-665
Published online: 04 Feb 2021
AbstractforDisruption of interferon-β production by the Npro of atypical porcine pestivirus | Full Text | References | PDF (3.8 MB) | EPUB
  • 1792 Views
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Article
The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo
Marcel Gischke, Ola Bagato, Angele Breithaupt, David Scheibner, Claudia Blaurock, Melina Vallbracht, Axel Karger, Beate Crossley, Jutta Veits, Eva Böttcher-Friebertshäuser, Thomas C. Mettenleiter & Elsayed M. Abdelwhab
Pages: 666-678
Published online: 04 Feb 2021
AbstractforThe role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 2154 Views
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Article
Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network
Yujie Miao, Peiyu Han, Dong Hua, Renwu Zhou, Zhengbing Guan, Qing Lv & Xiaofeng Dai
Pages: 679-689
Published online: 08 Feb 2021
AbstractforCold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Hemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling
José M. Rojas, Elena Pascual, Sean R. Wattegedera, Miguel Avia, César Santiago, Verónica Martín, Gary Entrican & Noemí Sevilla
Pages: 690-703
Published online: 12 Feb 2021
AbstractforHemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks
Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu & Jianguo Wu
Pages: 704-722
Published online: 16 Feb 2021
AbstractforSox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks | Full Text | References | PDF (5.5 MB) | EPUB
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Review Article

Review Article
Pathogenicity and virulence of Clostridium perfringens
Iman Mehdizadeh Gohari, Mauricio A. Navarro, Jihong Li, Archana Shrestha, Francisco Uzal & Bruce A. McClane
Pages: 723-753
Published online: 12 Apr 2021
AbstractforPathogenicity and virulence of Clostridium perfringens | Full Text | References | PDF (3.4 MB) | EPUB
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Research Paper

Article
Domain in Fiber-2 interacted with KPNA3/4 significantly affects the replication and pathogenicity of the highly pathogenic FAdV-4
Quan Xie, Weikang Wang, Luyuan Li, Qiuqi Kan, Hui Fu, Tuoyu Geng, Tuofan Li, Zhimin Wan, Wei Gao, Hongxia Shao, Aijian Qin & Jianqiang Ye
Pages: 754-765
Published online: 22 Feb 2021
AbstractforDomain in Fiber-2 interacted with KPNA3/4 significantly affects the replication and pathogenicity of the highly pathogenic FAdV-4 | Full Text | References | PDF (1.6 MB) | EPUB
  • 2178 Views
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Review Article

Review Article
Pathogenicity and virulence of Streptococcus pneumoniae: Cutting to the chase on proteases
Mary E. Marquart
Pages: 766-787
Published online: 04 Mar 2021
AbstractforPathogenicity and virulence of Streptococcus pneumoniae: Cutting to the chase on proteases | Full Text | References | PDF (1.1 MB) | EPUB
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Review Article
Infection strategies of mycoplasmas: Unraveling the panoply of virulence factors
Chen Yiwen, Wu Yueyue, Qin Lianmei, Zhu Cuiming & You Xiaoxing
Pages: 788-817
Published online: 11 Mar 2021
AbstractforInfection strategies of mycoplasmas: Unraveling the panoply of virulence factors | Full Text | References | PDF (999.8 KB) | EPUB
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Review Article
Galleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus
Marie-Fleur Durieux, Élise Melloul, Sana Jemel, Lolita Roisin, Marie-Laure Dardé, Jacques Guillot, Éric Dannaoui & Françoise Botterel
Pages: 818-834
Published online: 08 Mar 2021
AbstractforGalleria mellonella as a screening tool to study virulence factors of Aspergillus fumigatus | Full Text | References | PDF (1.8 MB) | EPUB
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Research Paper

Article
Therapeutic implications of C. albicans-S. aureus mixed biofilm in a murine subcutaneous catheter model of polymicrobial infection
Taissa Vila, Eric F. Kong, Daniel Montelongo-Jauregui, Patrick Van Dijck, Amol C. Shetty, Carrie McCracken, Vincent M. Bruno & Mary Ann Jabra-Rizk
Pages: 835-851
Published online: 08 Mar 2021
AbstractforTherapeutic implications of C. albicans-S. aureus mixed biofilm in a murine subcutaneous catheter model of polymicrobial infection | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
Catalase impairs Leishmania mexicana development and virulence
Jovana Sádlová, Lucie Podešvová, Tomáš Bečvář, Claretta Bianchi, Evgeny S. Gerasimov, Andreu Saura, Kristýna Glanzová, Tereza Leštinová, Nadezhda S. Matveeva, Ľubomíra Chmelová, Denisa Mlacovská, Tatiana Spitzová, Barbora Vojtková, Petr Volf, Vyacheslav Yurchenko & Natalya Kraeva
Pages: 852-867
Published online: 16 Mar 2021
AbstractforCatalase impairs Leishmania mexicana development and virulence | Full Text | References | PDF (868.9 KB) | EPUB | Supplemental
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Article
PE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction between M. tuberculosis and host cells
Flavio De Maio, Alessandro Salustri, Basem Battah, Ivana Palucci, Federica Marchionni, Silvia Bellesi, Valentina Palmieri, Massimiliano Papi, Eliza Kramarska, Maurizio Sanguinetti, Michela Sali, Rita Berisio & Giovanni Delogu
Pages: 868-884
Published online: 23 Mar 2021
AbstractforPE_PGRS3 ensures provision of the vital phospholipids cardiolipin and phosphatidylinositols by promoting the interaction between M. tuberculosis and host cells | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Review Article

Review Article
Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity
Satoko Yamaoka & Hideki Ebihara
Pages: 885-901
Published online: 18 Mar 2021
AbstractforPathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity | Full Text | References | PDF (1.3 MB) | EPUB
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Research Paper

Article
Transmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenic E. coli
Jenia Gershberg, Dor Braverman & Neta Sal-Man
Pages: 902-917
Published online: 17 Mar 2021
AbstractforTransmembrane domains of type III-secreted proteins affect bacterial-host interactions in enteropathogenic E. coli | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Review Article

Review Article
Immune dysregulation and system pathology in COVID-19
Muhammad Jamal, Hina Iqbal Bangash, Maria Habiba, Yufei Lei, Tian Xie, Jiaxing Sun, Zimeng Wei, Zixi Hong, Liang Shao & Qiuping Zhang
Pages: 918-936
Published online: 23 Mar 2021
AbstractforImmune dysregulation and system pathology in COVID-19 | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Research Paper

Article
Enhancing the chemical transformation of Candida parapsilosis
Tibor Németh, Joshua D. Nosanchuk, Csaba Vagvolgyi & Attila Gacser
Pages: 937-950
Published online: 17 Mar 2021
AbstractforEnhancing the chemical transformation of Candida parapsilosis | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Reductive evolution of virulence repertoire to drive the divergence between community- and hospital-associated methicillin-resistant Staphylococcus aureus of the ST1 lineage
Marina Farrel Côrtes, Ana Maria N. Botelho, Paula Terra Bandeira, William Mouton, Cedric Badiou, Michèle Bes, Nicholas C. B. Lima, André Elias R. Soares, Rangel C. Souza, Luiz G. P. Almeida, Patricia Martins-Simoes, Ana T. R. Vasconcelos, Marisa F. Nicolás, Frédéric Laurent, Paul J. Planet & Agnes M. S. Figueiredo
Pages: 951-967
Published online: 18 Mar 2021
AbstractforReductive evolution of virulence repertoire to drive the divergence between community- and hospital-associated methicillin-resistant Staphylococcus aureus of the ST1 lineage | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
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Review Article

Review Article
Pathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage
Usama Ashraf, Zhen Ding, Shunzhou Deng, Jing Ye, Shengbo Cao & Zheng Chen
Pages: 968-980
Published online: 16 Mar 2021
AbstractforPathogenicity and virulence of Japanese encephalitis virus: Neuroinflammation and neuronal cell damage | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Altered expression of genes related to innate antifungal immunity in the absence of galectin-3
Caroline Patini Rezende, Patricia Kellen Martins Oliveira Brito, Andre Moreira Pessoni, Thiago Aparecido Da Silva, Gustavo H Goldman & Fausto Almeida
Pages: 981-988
Published online: 29 Mar 2021
AbstractforAltered expression of genes related to innate antifungal immunity in the absence of galectin-3 | Full Text | References | PDF (932.1 KB) | EPUB | Supplemental
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Article
Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection
Dorothea Bünsow, Eshraq Tantawy, Tjorven Ostermeier, Heike Bähre, Annette Garbe, Jesper Larsen & Volker Winstel
Pages: 989-1002
Published online: 29 Mar 2021
AbstractforMethicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Tribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria
Wilhelm Bertrams, Nora S. Lindhauer, Marie Christin Rieke, Anne Paas, Kerstin Hoffmann, Brandon Greene, Alexander Visekruna, Andreas Vilcinskas, Kerstin Seidel & Bernd Schmeck
Pages: 1003-1010
Published online: 12 Apr 2021
AbstractforTribolium castaneum defensin 1 kills Moraxella catarrhalis in an in vitro infection model but does not harm commensal bacteria | Full Text | References | PDF (1,000.3 KB) | EPUB | Supplemental
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Article
Attenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model
Xinrong Zhou, Xinna Ge, Yongning Zhang, Jun Han, Xin Guo, Yanhong Chen, Lei Zhou & Hanchun Yang
Pages: 1011-1021
Published online: 02 Apr 2021
AbstractforAttenuation of porcine deltacoronavirus disease severity by porcine reproductive and respiratory syndrome virus coinfection in a weaning pig model | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Review Article

Review Article
Treading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions
Upayan Patra, Urbi Mukhopadhyay, Arpita Mukherjee, Shanta Dutta & Mamta Chawla-Sarkar
Pages: 1022-1062
Published online: 05 Apr 2021
AbstractforTreading a HOSTile path: Mapping the dynamic landscape of host cell–rotavirus interactions to explore novel host-directed curative dimensions | Full Text | References | PDF (5.7 MB) | EPUB
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Research Paper

Article
Virulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models
Ainara Hernando-Ortiz, Estibaliz Mateo, Aitzol Perez-Rodriguez, Piet W.J. de Groot, Guillermo Quindós & Elena Eraso
Pages: 1063-1075
Published online: 12 Apr 2021
AbstractforVirulence of Candida auris from different clinical origins in Caenorhabditis elegans and Galleria mellonella host models | Full Text | References | PDF (501.8 KB) | EPUB | Supplemental
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Article
Repurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans
Hajar Yaakoub, Cindy Staerck, Sara Mina, Charlotte Godon, Maxime Fleury, Jean-Philippe Bouchara & Alphonse Calenda
Pages: 1076-1090
Published online: 07 Apr 2021
AbstractforRepurposing of auranofin and honokiol as antifungals against Scedosporium species and the related fungus Lomentospora prolificans | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 1874 Views
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Article
Calcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli
Chi Zhang, Yiran Ren, Huiyu Gu, Lu Gao, Yuanwei Zhang & Ling Lu
Pages: 1091-1110
Published online: 12 Apr 2021
AbstractforCalcineurin-mediated intracellular organelle calcium homeostasis is required for the survival of fungal pathogens upon extracellular calcium stimuli | Full Text | References | PDF (9.1 MB) | EPUB | Supplemental
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Article
Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells
Ju-Yi Peng, Dai-Lun Shin, Guangxing Li, Nai-Huei Wu & Georg Herrler
Pages: 1111-1121
Published online: 25 May 2021
AbstractforTime-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Review Article

Review Article
Pathogenicity and Virulence of Legionella: Intracellular replication and host response
Deepika Chauhan & Stephanie R. Shames
Pages: 1122-1144
Published online: 12 Apr 2021
AbstractforPathogenicity and Virulence of Legionella: Intracellular replication and host response | Full Text | References | PDF (1.4 MB) | EPUB
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Review Article
Pathogenicity and virulence of West Nile virus revisited eight decades after its first isolation
Juan-Carlos Saiz, Miguel A. Martín-Acebes, Ana B. Blázquez, Estela Escribano-Romero, Teresa Poderoso & Nereida Jiménez de Oya
Pages: 1145-1173
Published online: 12 Apr 2021
AbstractforPathogenicity and virulence of West Nile virus revisited eight decades after its first isolation | Full Text | References | PDF (2.3 MB) | EPUB
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Review Article
Pathogenicity and virulence of hepatitis A virus
Rosa M Pintó, Francisco-Javier Pérez-Rodríguez, Maria-Isabel Costafreda, Gemma Chavarria-Miró, Susana Guix, Enric Ribes & Albert Bosch
Pages: 1174-1185
Published online: 12 Apr 2021
AbstractforPathogenicity and virulence of hepatitis A virus | Full Text | References | PDF (1.5 MB) | EPUB
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Research Paper

Article
Intracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins
Anke Siegmund, Muhammad Awais Afzal, Felix Tetzlaff, Daniela Keinhörster, Fabio Gratani, Kerstin Paprotka, Martin Westermann, Sandor Nietzsche, Christiane Wolz, Martin Fraunholz, Christian A. Hübner, Bettina Löffler & Lorena Tuchscherr
Pages: 1186-1198
Published online: 12 Apr 2021
AbstractforIntracellular persistence of Staphylococcus aureus in endothelial cells is promoted by the absence of phenol-soluble modulins | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study
Yong Xiao, Dongwen Wu, Xiao Shi, Shuzhong Liu, Xudong Hu, Chenliang Zhou, Xia Tian, Huimin Liu, Hui Long, Zhihong Li, Ji Wang, Tao Tan, Ying Xu, Bitao Chen, Ting Liu, Heng Zhang, Shihua Zheng, Shunlin Hu, Jun Song, Jie Tang, Jichun Song, Zhengwei Cheng, Weitian Xu, Yongxiang Shen, Wenhu Yu, Yong Xu, Jiao Li, Jing Zhou, Fen Wang & Mingkai Chen
Pages: 1199-1208
Published online: 19 Apr 2021
AbstractforHigh Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study | Full Text | References | PDF (493.5 KB) | EPUB | Supplemental
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Article
Quasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis
Rongsui Gao, Wenhong Zu, Yang Liu, Junhua Li, Zeyao Li, Yanling Wen, Haiyan Wang, Jing Yuan, Lin Cheng, Shengyuan Zhang, Yu Zhang, Shuye Zhang, Weilong Liu, Xun Lan, Lei Liu, Feng Li & Zheng Zhang
Pages: 1209-1226
Published online: 25 May 2021
AbstractforQuasispecies of SARS-CoV-2 revealed by single nucleotide polymorphisms (SNPs) analysis | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection
Nathan Scott Kieswetter, Mumin Ozturk, Shelby-Sara Jones, Sibusiso Senzani, Melissa Dalcina Chengalroyen, Frank Brombacher, Bavesh Kana & Reto Guler
Pages: 1227-1238
Published online: 13 May 2021
AbstractforDeletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1930 Views
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Article
Decreased temperature increases the expression of a disordered bacterial late embryogenesis abundant (LEA) protein that enhances natural transformation
Terhi Maula, Nelli Vahvelainen, Helena Tossavainen, Tuuli Koivunen, Marja T. Pöllänen, Anders Johansson, Perttu Permi & Riikka Ihalin
Pages: 1239-1257
Published online: 03 May 2021
AbstractforDecreased temperature increases the expression of a disordered bacterial late embryogenesis abundant (LEA) protein that enhances natural transformation | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Genomic population structure of Helicobacter pylori Shanghai isolates and identification of genomic features uniquely linked with pathogenicity
Feng Yang, Jinghao Zhang, Su Wang, Zhaoyang Sun, Jun Zhou, Feng Li, Yue Liu, Li Ding, Yixin Liu, Wenjing Chi, Tao Liu, Yongqun He, Ping Xiang, Zhijun Bao, Michal A. Olszewski, Hu Zhao & Yanmei Zhang
Pages: 1258-1270
Published online: 27 Apr 2021
AbstractforGenomic population structure of Helicobacter pylori Shanghai isolates and identification of genomic features uniquely linked with pathogenicity | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3439 Views
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Article
Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice
Milan Kuchař, Petr Kosztyu, Veronika Daniel Lišková, Jiří Černý, Hana Petroková, Eliška Vróblová, Michal Malý, Lucie Vaňková, Michal Křupka, Leona Rašková Kafková, Pavlína Turánek Knotigová, Jarmila Dušková, Jan Dohnálek, Josef Mašek, Jaroslav Turánek, Milan Raška & Petr Malý
Article: 1920251
Published online: 16 May 2021
AbstractforMyomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Editorial

Editorial
Mitigating the threat of emerging infectious diseases; a coevolutionary perspective
Cock Van Oosterhout
Pages: 1288-1295
Published online: 06 May 2021
First Page PreviewforMitigating the threat of emerging infectious diseases; a coevolutionary perspective | Full Text | References | PDF (496.1 KB) | EPUB
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Research Paper

Article
Whole-genome characterization of hemolytic uremic syndrome-causing Shiga toxin-producing Escherichia coli in Sweden
Ying Hua, Milan Chromek, Anne Frykman, Cecilia Jernberg, Valya Georgieva, Sverker Hansson, Ji Zhang, Ann Katrine Marits, Chengsong Wan, Andreas Matussek & Xiangning Bai
Pages: 1296-1305
Published online: 03 May 2021
AbstractforWhole-genome characterization of hemolytic uremic syndrome-causing Shiga toxin-producing Escherichia coli in Sweden | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 1861 Views
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Article
DIM5/KMT1 controls fungal insect pathogenicity and genome stability by methylation of histone H3K4, H3K9 and H3K36
Kang Ren, Ya-Ni Mou, Sen-Miao Tong, Sheng-Hua Ying & Ming-Guang Feng
Pages: 1306-1322
Published online: 06 May 2021
AbstractforDIM5/KMT1 controls fungal insect pathogenicity and genome stability by methylation of histone H3K4, H3K9 and H3K36 | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 2109 Views
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Article
Genetic diversity and evolution of the virulence plasmids encoding aerobactin and salmochelin in Klebsiella pneumoniae
Dongxing Tian, Meng Wang, Ying Zhou, Dakang Hu, Hong-Yu Ou & Xiaofei Jiang
Pages: 1323-1333
Published online: 10 May 2021
AbstractforGenetic diversity and evolution of the virulence plasmids encoding aerobactin and salmochelin in Klebsiella pneumoniae | Full Text | References | PDF (2 MB) | EPUB
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Article
Evaluation of hepatitis E antigen kinetics and its diagnostic utility for prediction of the outcomes of hepatitis E virus genotype 1 infection
Mohamed A. El-Mokhtar, Haidi Karam-Allah Ramadan, Muhamad R. Abdel Hameed, Ayat M. Kamel, Sahar A. Mandour, Maha Ali, Mohamed A. Y. Abdel-Malek, Doaa M. Abd El-Kareem, Sara Adel, Eman H. Salama, Khaled Abo Bakr Khalaf & Ibrahim M. Sayed
Pages: 1334-1344
Published online: 18 May 2021
AbstractforEvaluation of hepatitis E antigen kinetics and its diagnostic utility for prediction of the outcomes of hepatitis E virus genotype 1 infection | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
β-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture
Wenqing Fan, Weifeng Yuan, Xiuyan Ding & Liqian Zhu
Pages: 1345-1361
Published online: 19 May 2021
Abstractforβ-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture | Full Text | References | PDF (2.3 MB) | EPUB
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Article
A virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture
Yan Zhao, Shuai Jiang, Jian Zhang, Xiao-Lu Guan, Bo-Guang Sun & Li Sun
Pages: 1362-1376
Published online: 19 May 2021
AbstractforA virulent Bacillus cereus strain from deep-sea cold seep induces pyroptosis in a manner that involves NLRP3 inflammasome, JNK pathway, and lysosomal rupture | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
A phage protein-derived antipathogenic peptide that targets type IV pilus assembly
In-Young Chung, Bi-o Kim, Ju-Hyun Han, Jonggwan Park, Hee Kyoung Kang, Yoonkyung Park & You-Hee Cho
Pages: 1377-1387
Published online: 19 May 2021
AbstractforA phage protein-derived antipathogenic peptide that targets type IV pilus assembly | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
A biological and genomic comparison of a drug-resistant and a drug-susceptible strain of Candida auris isolated from Beijing, China
Shuru Fan, Ping Zhan, Jian Bing, Ning Jiang, Yingnan Huang, Dongke Chen, Tianren Hu, Han Du & Guanghua Huang
Pages: 1388-1399
Published online: 01 Jun 2021
AbstractforA biological and genomic comparison of a drug-resistant and a drug-susceptible strain of Candida auris isolated from Beijing, China | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
Adaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes
Violeta Lara-Aguilar, Cristina Rueda, Irene García-Barbazán, Sarai Varona, Sara Monzón, Pilar Jiménez, Isabel Cuesta, Ángel Zaballos & Óscar Zaragoza
Pages: 1400-1417
Published online: 28 Jun 2021
AbstractforAdaptation of the emerging pathogenic yeast Candida auris to high caspofungin concentrations correlates with cell wall changes | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
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Article
Staphylococcus aureus N-terminus formylated δ-toxin tends to form amyloid fibrils, while the deformylated δ-toxin tends to form functional oligomer complexes
Xinyu Zhou, Yuling Zheng, Qingyu Lv, Decong Kong, Bin Ji, Xuelian Han, Dongsheng Zhou, Zeyu Sun, Li Zhu, Peng Liu, Hua Jiang & Yongqiang Jiang
Pages: 1418-1437
Published online: 24 May 2021
AbstractforStaphylococcus aureus N-terminus formylated δ-toxin tends to form amyloid fibrils, while the deformylated δ-toxin tends to form functional oligomer complexes | Full Text | References | PDF (10.8 MB) | EPUB
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Article
Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone
Marie Robbe-Saule, Mélanie Foulon, Isabelle Poncin, Lucille Esnault, Hugo Varet, Rachel Legendre, Alban Besnard, Anna E. Grzegorzewicz, Mary Jackson, Stéphane Canaan, Laurent Marsollier & Estelle Marion
Pages: 1438-1451
Published online: 09 Jun 2021
AbstractforTranscriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolactone | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants
Jesús Pérez-Ortega, Roel M. Van Harten, Ria Van Boxtel, Michel Plisnier, Marc Louckx, Dominique Ingels, Henk P. Haagsman & Jan Tommassen
Pages: 1452-1468
Published online: 31 May 2021
AbstractforReduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Review Article

Review Article
An Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence
Charles D. Morin, Eric Déziel, Jeff Gauthier, Roger C. Levesque & Gee W. Lau
Pages: 1469-1507
Published online: 27 Jun 2021
AbstractforAn Organ System-Based Synopsis of Pseudomonas aeruginosa Virulence | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Genetic architecture of transmission stage production and virulence in schistosome parasites
Winka Le Clec’h, Frédéric D. Chevalier, Marina McDew-White, Vinay Menon, Grace-Ann Arya & Timothy J.C. Anderson
Pages: 1508-1526
Published online: 24 Jun 2021
AbstractforGenetic architecture of transmission stage production and virulence in schistosome parasites | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Developmental consequences of children born from mothers with telbivudine treatment during late pregnancy: A prospective study with 3-year follow-up
Wei Yi, Xiuzhen Cao, Zhan Zeng, Weihua Cao, Ying Zhang, Fangfang Sun, Ying Wang, Gang Wan, Minghui Li & Yao Xie
Pages: 1527-1537
Published online: 12 Jun 2021
AbstractforDevelopmental consequences of children born from mothers with telbivudine treatment during late pregnancy: A prospective study with 3-year follow-up | Full Text | References | PDF (397.2 KB) | EPUB
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Article
The biological role of MutT in the pathogenesis of the zoonotic pathogen Streptococcus suis serotype 2
Quan Li, Xia Fei, Yuhang Zhang, Genglin Guo, Huoying Shi & Wei Zhang
Pages: 1538-1549
Published online: 02 Jun 2021
AbstractforThe biological role of MutT in the pathogenesis of the zoonotic pathogen Streptococcus suis serotype 2 | Full Text | References | PDF (2 MB) | EPUB
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Review Article

Review Article
Insights of roles played by septins in pathogenic fungi
Lin Li, Xue-Ming Zhu, Zhen-Zhu Su, Maurizio Del Poeta, Xiao-Hong Liu & Fu-Cheng Lin
Pages: 1550-1562
Published online: 07 Jun 2021
AbstractforInsights of roles played by septins in pathogenic fungi | Full Text | References | PDF (3.9 MB) | EPUB
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Article
A novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungus Ustilaginoidea virens
Xiaoyang Chen, Pingping Li, Hao Liu, Xiaolin Chen, Junbin Huang, Chaoxi Luo, Guotian Li, Tom Hsiang, David B. Collinge & Lu Zheng
Pages: 1563-1579
Published online: 04 Aug 2021
AbstractforA novel transcription factor UvCGBP1 regulates development and virulence of rice false smut fungus Ustilaginoidea virens | Full Text | References | PDF (6 MB) | EPUB | Supplemental
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Article
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
Elisa Fanunza, Fabrizio Carletti, Marina Quartu, Nicole Grandi, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito & Enzo Tramontano
Pages: 1580-1596
Published online: 02 Aug 2021
AbstractforZika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2 | Full Text | References | PDF (4.3 MB) | EPUB
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Article
Seroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA
Mythili Dileepan, Da Di, Qinfeng Huang, Shamim Ahmed, Daniel Heinrich, Hinh Ly & Yuying Liang
Pages: 1597-1609
Published online: 14 Jun 2021
AbstractforSeroprevalence of SARS-CoV-2 (COVID-19) exposure in pet cats and dogs in Minnesota, USA | Full Text | References | PDF (481.3 KB) | EPUB
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Article
Helicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence
Sue-Fen Chiu, Kai-Wen Teng, Po-Chuan Wang, Hsin-Yu Chung, Chun-Jen Wang, Hui-Chun Cheng & Mou-Chieh Kao
Pages: 1610-1628
Published online: 14 Jun 2021
AbstractforHelicobacter pylori GmhB enzyme involved in ADP-heptose biosynthesis pathway is essential for lipopolysaccharide biosynthesis and bacterial virulence | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Review Article

Article
Too young to die? How aging affects cellular innate immune responses to influenza virus and disease severity
Christopher M. Harpur, Mélanie A. Le Page & Michelle D. Tate
Pages: 1629-1646
Published online: 21 Jun 2021
AbstractforToo young to die? How aging affects cellular innate immune responses to influenza virus and disease severity | Full Text | References | PDF (881.5 KB) | EPUB
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Research Paper

Article
Study of the host specificity of PB1-F2-associated virulence
Joëlle Mettier, Daniel Marc, Laura Sedano, Bruno Da Costa, Christophe Chevalier & Ronan Le Goffic
Pages: 1647-1660
Published online: 14 Jun 2021
AbstractforStudy of the host specificity of PB1-F2-associated virulence | Full Text | References | PDF (7.9 MB) | EPUB | Supplemental
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Article
YhjC is a novel transcriptional regulator required for Shigella flexneri virulence
Wanwu Li, Lingyan Jiang, Xiaoqian Liu, Rui Guo, Shuai Ma, Jingting Wang, Shuangshuang Ma, Shujie Li & Huiying Li
Pages: 1661-1671
Published online: 21 Jun 2021
AbstractforYhjC is a novel transcriptional regulator required for Shigella flexneri virulence | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Article
Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype
Irene Rodríguez-Arce, Xabier Morales, Mikel Ariz, Begoña Euba, Nahikari López-López, Maider Esparza, Derek W. Hood, José Leiva, Carlos Ortíz-de-Solórzano & Junkal Garmendia
Pages: 1672-1688
Published online: 12 Jul 2021
AbstractforDevelopment and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Article
Profiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome
Cerezo-Cortés María Irene, Rodríguez-Castillo Juan Germán, López-Leal Gamaliel, Mata-Espinosa Dulce Adriana, Bini Estela Isabel, Marquina–Casitllo Brenda Nohemí, Barrios Payan Jorge, Zatarain-Barrón Zyanya Lucía, Bobadilla del Valle Myriam, Cornejo-Granados F, Ochoa-Leyva Adrian, Murcia Martha Isabel & Hernández-Pando Rogelio
Pages: 1689-1704
Published online: 06 Jul 2021
AbstractforProfiling the immune response to Mycobacterium tuberculosis Beijing family infection: a perspective from the transcriptome | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Long noncoding RNAs are potentially involved in the degeneration of virulence in an aphid-obligate pathogen, Conidiobolus obscurus (Entomophthoromycotina)
Guofang Ye, Lvhao Zhang & Xiang Zhou
Pages: 1705-1716
Published online: 24 Jun 2021
AbstractforLong noncoding RNAs are potentially involved in the degeneration of virulence in an aphid-obligate pathogen, Conidiobolus obscurus (Entomophthoromycotina) | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Commentary

COVID-19 variants as moving targets and how to stop them by glycoengineered whole-virus vaccines
Uri Galili
Pages: 1717-1720
Published online: 25 Jul 2021
First Page PreviewforCOVID-19 variants as moving targets and how to stop them by glycoengineered whole-virus vaccines | Full Text | References | PDF (548.3 KB) | EPUB
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Research Paper

Article
The tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication
Tuofan Li, Jing Xie, Xiaohui Yao, Jun Zhang, Chunping Li, Dan Ren, Luyuan Li, Quan Xie, Hongxia Shao, Aijian Qin & Jianqiang Ye
Pages: 1721-1731
Published online: 25 Jun 2021
AbstractforThe tyrosine phosphatase SHP-2 dephosphorylated by ALV-J via its Env efficiently promotes ALV-J replication | Full Text | References | PDF (1.8 MB) | EPUB
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Editorial

Editorial
Modulating the host immune response to fight against COVID-19: Where are we in 2021?
Decsa Medika Hertanto, Henry Sutanto, Bayu Satria Wiratama & Citrawati Dyah Kencono Wungu
Pages: 1732-1736
Published online: 05 Jul 2021
First Page PreviewforModulating the host immune response to fight against COVID-19: Where are we in 2021? | Full Text | References | PDF (1.7 MB) | EPUB
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Research Paper

Article
Synergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistant Vibrio alginolyticus
Su-fang Kuang, Yue-tao Chen, Jia-jie Chen, Xuan-xian Peng, Zhuanggui Chen & Hui Li
Pages: 1737-1753
Published online: 12 Jul 2021
AbstractforSynergy of alanine and gentamicin to reduce nitric oxide for elevating killing efficacy to antibiotic-resistant Vibrio alginolyticus | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
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Article
Suppressed inflammation in obese children induced by a high-fiber diet is associated with the attenuation of gut microbial virulence factor genes
Hui Li, Guojun Wu, Liping Zhao & Menghui Zhang
Pages: 1754-1770
Published online: 08 Jul 2021
AbstractforSuppressed inflammation in obese children induced by a high-fiber diet is associated with the attenuation of gut microbial virulence factor genes | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Review Article

Review Article
The journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences
Amal F. Alshammary & Abdulrahman M. Al-Sulaiman
Pages: 1771-1794
Published online: 12 Jul 2021
AbstractforThe journey of SARS-CoV-2 in human hosts: a review of immune responses, immunosuppression, and their consequences | Full Text | References | PDF (3.1 MB) | EPUB
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Research Paper

Article
LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination
Dingwen Hu, Yingchong Wang, Aixin Li, Qin Li, Caifeng Wu, Muhammad Adnan Shereen, Shanyu Huang, Kailang Wu, Ying Zhu, Wenbiao Wang & Jianguo Wu
Pages: 1795-1807
Published online: 20 Jul 2021
AbstractforLAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Transcriptome analysis of porcine PBMCs reveals lipopolysaccharide-induced immunomodulatory responses and crosstalk of immune and glucocorticoid receptor signaling
Zhiwei Li, Nares Trakooljul, Frieder Hadlich, Siriluck Ponsuksili, Klaus Wimmers & Eduard Murani
Pages: 1808-1824
Published online: 21 Jul 2021
AbstractforTranscriptome analysis of porcine PBMCs reveals lipopolysaccharide-induced immunomodulatory responses and crosstalk of immune and glucocorticoid receptor signaling | Full Text | References | PDF (4.3 MB) | EPUB | Supplemental
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Article
Functional analysis of seven regulators of G protein signaling (RGSs) in the nematode-trapping fungus Arthrobotrys oligospora
Ni Ma, Yining Zhao, Yunchuan Wang, Le Yang, Dongni Li, Jiangliu Yang, Kexin Jiang, Ke-Qin Zhang & Jinkui Yang
Pages: 1825-1840
Published online: 05 Jul 2021
AbstractforFunctional analysis of seven regulators of G protein signaling (RGSs) in the nematode-trapping fungus Arthrobotrys oligospora | Full Text | References | PDF (4 MB) | EPUB | Supplemental
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Article
Pneumococcal surface adhesion A protein (PsaA) interacts with human Annexin A2 on airway epithelial cells
Yoonsung Hu, Nogi Park, Keun Seok Seo, Joo Youn Park, Radha P. Somarathne, Natalene Vonkchalee, Katelyn Jackson, Alicia K. Olivier, Nicholas C. Fitzkee & Justin A. Thornton
Article: 1947176
Published online: 08 Jul 2021
AbstractforPneumococcal surface adhesion A protein (PsaA) interacts with human Annexin A2 on airway epithelial cells | Full Text | References | PDF (931.5 KB) | EPUB | Supplemental
  • 1961 Views
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Article
Koi sleepy disease as a pathophysiological and immunological consequence of a branchial infection of common carp with carp edema virus
Mikolaj Adamek, Felix Teitge, Ilka Baumann, Verena Jung-Schroers, Sahar Abd El Rahman, Richard Paley, Veronica Piackova, David Gela, Martin Kocour, Sebastian Rakers, Sven M. Bergmann, Martin Ganter & Dieter Steinhagen
Pages: 1855-1883
Published online: 16 Jul 2021
AbstractforKoi sleepy disease as a pathophysiological and immunological consequence of a branchial infection of common carp with carp edema virus | Full Text | References | PDF (7.4 MB) | EPUB | Supplemental
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Review Article

Review Article
The two-component signal transduction system and its regulation in Candida albicans
Binyou Liao, Xingchen Ye, Xi Chen, Yujie Zhou, Lei Cheng, Xuedong Zhou & Biao Ren
Pages: 1884-1899
Published online: 08 Jul 2021
AbstractforThe two-component signal transduction system and its regulation in Candida albicans | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Establishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection
Aiste Dijokaite, Maria Victoria Humbert, Emma Borkowski, Roberto M La Ragione & Myron Christodoulides
Pages: 1900-1920
Published online: 25 Jul 2021
AbstractforEstablishing an invertebrate Galleria mellonella greater wax moth larval model of Neisseria gonorrhoeae infection | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
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Review Article

Review Article
“Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants?
Jane Chepsergon, Thabiso E. Motaung & Lucy Novungayo Moleleki
Pages: 1921-1935
Published online: 25 Jul 2021
Abstractfor“Core” RxLR effectors in phytopathogenic oomycetes: A promising way to breeding for durable resistance in plants? | Full Text | References | PDF (913.9 KB) | EPUB
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Article
Whole genome analysis unveils genetic diversity and potential virulence determinants in Vibrio parahaemolyticus associated with disease outbreak among cultured Litopenaeus vannamei (Pacific white shrimp) in India
Kattapuni Suresh Prithvisagar, Ballamoole Krishna Kumar, Toshio Kodama, Praveen Rai, Tetsuya Iida, Iddya Karunasagar & Indrani Karunasagar
Pages: 1936-1949
Published online: 20 Aug 2021
AbstractforWhole genome analysis unveils genetic diversity and potential virulence determinants in Vibrio parahaemolyticus associated with disease outbreak among cultured Litopenaeus vannamei (Pacific white shrimp) in India | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Article
Analyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one species
Laura E. Hernández-Juárez, Margarita Camorlinga, Alfonso Méndez-Tenorio, Judith Flores Calderón, B. Carol Huang, DJ Darwin R. Bandoy, Bart C. Weimer & Javier Torres
Pages: 1950-1964
Published online: 25 Jul 2021
AbstractforAnalyses of publicly available Hungatella hathewayi genomes revealed genetic distances indicating they belong to more than one species | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Article
Acinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1
Zhiyuan An & Wenyi Ding
Pages: 1965-1979
Published online: 25 Jul 2021
AbstractforAcinetobacter baumannii up-regulates LncRNA-GAS5 and promotes the degradation of STX17 by blocking the activation of YY1 | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK
Xuelin Han, Xueting Su, Zhiqian Li, Yanxi Liu, Shuo Wang, Miao Zhu, Changjian Zhang, Fan Yang, Jingya Zhao, Xianping Li, Fangyan Chen & Li Han
Pages: 1980-1996
Published online: 02 Aug 2021
AbstractforComplement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway
Wudi Wei, Chuanyi Ning, Jiegang Huang, Gang Wang, Jingzhen Lai, Jing Han, Jinhao He, Hong Zhang, Bingyu Liang, Yanyan Liao, Thuy Le, Qiang Luo, Zhen Li, Junjun Jiang, Li Ye & Hao Liang
Pages: 1997-2012
Published online: 02 Aug 2021
AbstractforTalaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway | Full Text | References | PDF (3.7 MB) | EPUB
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Editorial

Editorial
COVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies
Cock van Oosterhout, Jessica F. Stephenson, Bart Weimer, Hinh Ly, Neil Hall & Kevin M. Tyler
Pages: 2013-2016
Published online: 29 Jul 2021
First Page PreviewforCOVID-19 adaptive evolution during the pandemic – Implications of new SARS-CoV-2 variants on public health policies | Full Text | References | PDF (596 KB) | EPUB
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Article
Trypanosoma evansi evades host innate immunity by releasing extracellular vesicles to activate TLR2-AKT signaling pathway
Ran Wei, Xin Li, Xiaocen Wang, Nan Zhang, Yuru Wang, Xichen Zhang, Pengtao Gong & Jianhua Li
Pages: 2017-2036
Published online: 05 Aug 2021
AbstractforTrypanosoma evansi evades host innate immunity by releasing extracellular vesicles to activate TLR2-AKT signaling pathway | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
Abrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs
Miaomiao Wang, José Alejandro Bohórquez, Yoandry Hinojosa, Sara Muñoz-González, Markus Gerber, Liani Coronado, Carmen Laura Perera, Matthias Liniger, Nicolas Ruggli & Llilianne Ganges
Pages: 2037-2049
Published online: 02 Aug 2021
AbstractforAbrogation of the RNase activity of Erns in a low virulence classical swine fever virus enhances the humoral immune response and reduces virulence, transmissibility, and persistence in pigs | Full Text | References | PDF (1.8 MB) | EPUB
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Article
The hypermucoviscosity of hypervirulent K. pneumoniae confers the ability to evade neutrophil-mediated phagocytosis
Qi Xu, Xuemei Yang, Edward Wai Chi Chan & Sheng Chen
Pages: 2050-2059
Published online: 02 Aug 2021
AbstractforThe hypermucoviscosity of hypervirulent K. pneumoniae confers the ability to evade neutrophil-mediated phagocytosis | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Review Article

Review Article
The pathogenesis and virulence of enterovirus-D68 infection
Syriam Sooksawasdi Na Ayudhya, Brigitta M. Laksono & Debby van Riel
Pages: 2060-2072
Published online: 19 Aug 2021
AbstractforThe pathogenesis and virulence of enterovirus-D68 infection | Full Text | References | PDF (978.5 KB) | EPUB
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Article
Host-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis
Christian Schwarz, Yasemin Töre, Vanessa Hoesker, Sabine Ameling, Katja Grün, Uwe Völker, P. Christian Schulze, Marcus Franz, Cornelius Faber, Frieder Schaumburg, Silke Niemann & Verena Hoerr
Pages: 2073-2087
Published online: 07 Sep 2021
AbstractforHost-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Stabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment
Rita Pombinho, Jorge Pinheiro, Mariana Resende, Diana Meireles, Sirpa Jalkanen, Sandra Sousa & Didier Cabanes
Pages: 2088-2103
Published online: 10 Aug 2021
AbstractforStabilin-1 plays a protective role against Listeria monocytogenes infection through the regulation of cytokine and chemokine production and immune cell recruitment | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Laser capture microdissection to study Bacillus cereus iron homeostasis gene expression during Galleria mellonella in vivo gut colonization
Laurent Consentino, Agnès Rejasse, Nicolas Crapart, Claudia Bevilacqua & Christina Nielsen-LeRoux
Pages: 2104-2121
Published online: 10 Aug 2021
AbstractforLaser capture microdissection to study Bacillus cereus iron homeostasis gene expression during Galleria mellonella in vivo gut colonization | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
ppGpp signaling plays a critical role in virulence of Acinetobacter baumannii
Kyeongmin Kim, Maidul Islam, Hye-won Jung, Daejin Lim, Kwangsoo Kim, Sung-Gwon Lee, Chungoo Park, Je Chul Lee & Minsang Shin
Pages: 2122-2132
Published online: 10 Aug 2021
AbstractforppGpp signaling plays a critical role in virulence of Acinetobacter baumannii | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Oral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice
Wenwen Zhu, Jia Wang, Na Zhao, Rui Zheng, Dalu Wang, Weiwei Liu & Beixing Liu
Pages: 2133-2148
Published online: 12 Aug 2021
AbstractforOral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A
Li Wang, Shisong Jing, Han Qu, Kai Wang, Yajing Jin, Ying Ding, Lin Yang, Hangqian Yu, Yan Shi, Qianxue Li & Dacheng Wang
Pages: 2149-2161
Published online: 09 Aug 2021
AbstractforOrientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Article
Diversification and prevalence of the quinolone resistance crpP genes and the crpP-carrying Tn6786-related integrative and conjugative elements in Pseudomonas aeruginosa
Zhichen Zhu, Huiying Yang, Zhe Yin, Ying Jing, Yuee Zhao, Hongyu Fu, Hong Du & Dongsheng Zhou
Pages: 2162-2170
Published online: 17 Aug 2021
AbstractforDiversification and prevalence of the quinolone resistance crpP genes and the crpP-carrying Tn6786-related integrative and conjugative elements in Pseudomonas aeruginosa | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
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Article
S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum
Dongya Shi, Yu Zhang, Jin Wang, Weichao Ren, Jie Zhang, Jane Ifunanya Mbadianya, Yuanye Zhu, Changjun Chen & Hongyu Ma
Pages: 2171-2185
Published online: 23 Aug 2021
AbstractforS-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Article
Transcriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones
Duaa Anabosi, Zohar Meir, Yana Shadkchan, Mariana Handelman, Ammar Abou-Kandil, Annie Yap, Daniel Urlings, Morgan S. Gold, Sven Krappmann, Hubertus Haas & Nir Osherov
Pages: 2186-2200
Published online: 01 Sep 2021
AbstractforTranscriptional response of Aspergillus fumigatus to copper and the role of the Cu chaperones | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
Importance of twitching and surface-associated motility in the virulence of Acinetobacter baumannii
Jordi Corral, María Pérez-Varela, Miquel Sánchez-Osuna, Pilar Cortés, Jordi Barbé & Jesús Aranda
Pages: 2201-2213
Published online: 13 Sep 2021
AbstractforImportance of twitching and surface-associated motility in the virulence of Acinetobacter baumannii | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
The ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells
Theodoros Kelesidis, Madhav Sharma, Anton Petcherski, Cristelle Hugo, Ellen O’Connor, Nan W Hultgren, Eleni Ritou, David S Williams, Orian S Shirihai & Srinivasa T Reddy
Pages: 2214-2227
Published online: 08 Sep 2021
AbstractforThe ApoA-I mimetic peptide 4F attenuates in vitro replication of SARS-CoV-2, associated apoptosis, oxidative stress and inflammation in epithelial cells | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Quantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains
Hong Wang, Li Wan, Jiahui Shi, Tao Zhang, Huiming Zhu, Songhao Jiang, Shuhong Meng, Shujia Wu, Jinshuai Sun, Lei Chang, Liqun Zhang, Kanglin Wan, Jiaqi Yang, Xiuqin Zhao, Haican Liu, Yao Zhang, Erhei Dai & Ping Xu
Pages: 2228-2246
Published online: 11 Oct 2021
AbstractforQuantitative proteomics reveals that dormancy-related proteins mediate the attenuation in mycobacterium strains | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Review Article

Review Article
Antimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields
Wanessa de Cassia Martins Antunes de Melo, Raimonda Celiešiūtė-Germanienė, Povilas Šimonis & Arūnas Stirkė
Pages: 2247-2272
Published online: 09 Sep 2021
AbstractforAntimicrobial photodynamic therapy (aPDT) for biofilm treatments. Possible synergy between aPDT and pulsed electric fields | Full Text | References | PDF (1.9 MB) | EPUB
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Review Article
Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity
In Soo Kim, Prashanta Silwal & Eun-Kyeong Jo
Pages: 2273-2284
Published online: 04 Sep 2021
AbstractforMitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity | Full Text | References | PDF (827.1 KB) | EPUB
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Article
Silkworm model for Bacillus anthracis infection and virulence determination
Atmika Paudel, Yoshikazu Furuta & Hideaki Higashi
Pages: 2285-2295
Published online: 07 Sep 2021
AbstractforSilkworm model for Bacillus anthracis infection and virulence determination | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Cleavage of E-cadherin by porcine respiratory bacterial pathogens facilitates airway epithelial barrier disruption and bacterial paracellular transmigration
Qi Cao, Wenbin Wei, Huan Wang, Zesong Wang, Yujin Lv, Menghong Dai, Chen Tan, Huanchun Chen & Xiangru Wang
Pages: 2296-2313
Published online: 05 Sep 2021
AbstractforCleavage of E-cadherin by porcine respiratory bacterial pathogens facilitates airway epithelial barrier disruption and bacterial paracellular transmigration | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
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Review Article
The promise of endogenous and exogenous riboflavin in anti-infection
Junwen Lei, Caiyan Xin, Wei Xiao, Wenbi Chen & Zhangyong Song
Pages: 2314-2326
Published online: 07 Sep 2021
AbstractforThe promise of endogenous and exogenous riboflavin in anti-infection | Full Text | References | PDF (1.1 MB) | EPUB
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Article
A clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity
Edel Pérez-López, Md Musharaf Hossain, Yangdou Wei, Christopher D. Todd & Peta C Bonham-Smith
Pages: 2327-2340
Published online: 13 Sep 2021
AbstractforA clubroot pathogen effector targets cruciferous cysteine proteases to suppress plant immunity | Full Text | References | PDF (3 MB) | EPUB | Supplemental
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Article
Helicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells
Chung-Yao Hsu, Jia-Yin Yeh, Chun-Ya Chen, Hui-Yu Wu, Meng-Hsuan Chiang, Chia-Lin Wu, Hwai-Jeng Lin, Cheng-Hsun Chiu & Chih-Ho Lai
Pages: 2341-2351
Published online: 10 Sep 2021
AbstractforHelicobacter pylori cholesterol-α-glucosyltransferase manipulates cholesterol for bacterial adherence to gastric epithelial cells | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Role of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection
Yuchen Li, Jianda Li, Xiuyu Wang, Qingxin Wu & Qian Yang
Pages: 2352-2365
Published online: 13 Sep 2021
AbstractforRole of intestinal extracellular matrix-related signaling in porcine epidemic diarrhea virus infection | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
MgaSpn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39
Shengnan Xiao, Weicai Suo, Jinghui Zhang, Xuemei Zhang, Yibing Yin, Xinlin Guo & Yuqiang Zheng
Pages: 2366-2381
Published online: 10 Sep 2021
AbstractforMgaSpn is a negative regulator of capsule and phosphorylcholine biosynthesis and influences the virulence of Streptococcus pneumoniae D39 | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Colibactin in avian pathogenic Escherichia coli contributes to the development of meningitis in a mouse model
Peili Wang, Jiaxiang Zhang, Yanfei Chen, Haoran Zhong, Heng Wang, Jianji Li, Guoqiang Zhu, Pengpeng Xia, Luying Cui, Jun Li, Junsheng Dong, Qingqing Gao & Xia Meng
Pages: 2382-2399
Published online: 16 Sep 2021
AbstractforColibactin in avian pathogenic Escherichia coli contributes to the development of meningitis in a mouse model | Full Text | References | PDF (13.2 MB) | EPUB
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Article
Glycosylation on envelope glycoprotein of duck Tembusu virus affects virus replication in vitro and contributes to the neurovirulence and pathogenicity in vivo
Dejian Liu, Xuyao Xiao, Peng Zhou, Huijun Zheng, Yaqian Li, Hui Jin, Anan Jongkaewwattana & Rui Luo
Pages: 2400-2414
Published online: 10 Sep 2021
AbstractforGlycosylation on envelope glycoprotein of duck Tembusu virus affects virus replication in vitro and contributes to the neurovirulence and pathogenicity in vivo | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Article
Genetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients
Astrid Lewin, Elisabeth Kamal, Torsten Semmler, Katja Winter, Sandra Kaiser, Hubert Schäfer, Lei Mao, Patience Eschenhagen, Claudia Grehn, Jennifer Bender & Carsten Schwarz
Pages: 2415-2429
Published online: 21 Sep 2021
AbstractforGenetic diversification of persistent Mycobacterium abscessus within cystic fibrosis patients | Full Text | References | PDF (769.4 KB) | EPUB | Supplemental
  • 2324 Views
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Article
Roborovski hamster (Phodopus roborovskii) strain SH101 as a systemic infection model of SARS-CoV-2
Chongkai Zhai, Mingda Wang, Hea-Jong Chung, Md. Mehedi Hassan, Seungkoo Lee, Hyeon-Jin Kim & Seong-Tshool Hong
Pages: 2430-2442
Published online: 14 Sep 2021
AbstractforRoborovski hamster (Phodopus roborovskii) strain SH101 as a systemic infection model of SARS-CoV-2 | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 2798 Views
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Article
Long noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms
Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu & Xiufan Liu
Pages: 2443-2460
Published online: 14 Sep 2021
AbstractforLong noncoding RNA#45 exerts broad inhibitory effect on influenza a virus replication via its stem ring arms | Full Text | References | PDF (5.6 MB) | EPUB | Supplemental
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Article
Coxiella burnetii infections in mice: Immunological responses to contemporary genotypes found in the US
Rachael A. Priestley, Cody B. Smith, Halie K. Miller & Gilbert J. Kersh
Pages: 2461-2473
Published online: 13 Sep 2021
AbstractforCoxiella burnetii infections in mice: Immunological responses to contemporary genotypes found in the US | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
Phenol-soluble modulins α are major virulence factors of Staphylococcus aureus secretome promoting inflammatory response in human epidermis
Alexia Damour, Brandon Robin, Luc Deroche, Lauranne Broutin, Nicolas Bellin, Julien Verdon, Gérard Lina, Franck Marie Leclère, Magali Garcia, Julie Cremniter, Nicolas Lévêque & Charles Bodet
Pages: 2474-2492
Published online: 13 Sep 2021
AbstractforPhenol-soluble modulins α are major virulence factors of Staphylococcus aureus secretome promoting inflammatory response in human epidermis | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Laura Seldeslachts, Lore Vanderbeke, Astrid Fremau, Agustin Reséndiz-Sharpe, Cato Jacobs, Bo Laeveren, Tessa Ostyn, Lieve Naesens, Matthias Brock, Frank L. Van De Veerdonk, Stephanie Humblet-Baron, Erik Verbeken, Katrien Lagrou, Joost Wauters & Greetje Vande Velde
Pages: 2493-2508
Published online: 21 Sep 2021
AbstractforEarly oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model | Full Text | References | PDF (4.9 MB) | EPUB | Supplemental
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Review
Pathogenicity and virulence of Listeria monocytogenes: A trip from environmental to medical microbiology
Juan J. Quereda, Alvaro Morón-García, Carla Palacios-Gorba, Charlotte Dessaux, Francisco García-del Portillo, M. Graciela Pucciarelli & Alvaro D. Ortega
Pages: 2509-2545
Published online: 06 Oct 2021
AbstractforPathogenicity and virulence of Listeria monocytogenes: A trip from environmental to medical microbiology | Full Text | References | PDF (9.2 MB) | EPUB
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Article
Exacerbation of Mycobacterium avium pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses
Yeeun Bak, Sang Chul Park, Dahee Shim, Yura Ha, Jumi Lee, Hongmin Kim, Kee Woong Kwon, Joo-Heon Yoon & Sung Jae Shin
Pages: 2546-2561
Published online: 04 Oct 2021
AbstractforExacerbation of Mycobacterium avium pulmonary infection by comorbid allergic asthma is associated with diminished mycobacterium-specific Th17 responses | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
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Article
Comparison of three Coxiella burnetii infectious routes in mice
Halie K. Miller, Rachael A. Priestley & Gilbert J. Kersh
Pages: 2562-2570
Published online: 27 Sep 2021
AbstractforComparison of three Coxiella burnetii infectious routes in mice | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Deciphering of Candida parapsilosis induced immune response in Drosophila melanogaster
Katalin Csonka, Zsolt Tasi, Viktor Vedelek, Csaba Vágvölgyi, Rita Sinka & Attila Gácser
Pages: 2571-2582
Published online: 27 Sep 2021
AbstractforDeciphering of Candida parapsilosis induced immune response in Drosophila melanogaster | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Review Article
Herpes simplex virus interference with immunity: Focus on dendritic cells
MA Farías, LF Duarte, EI Tognarelli & PA González
Pages: 2583-2607
Published online: 13 Dec 2021
AbstractforHerpes simplex virus interference with immunity: Focus on dendritic cells | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Pathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host
Thomas Belcher, Violaine Dubois, Alex Rivera-Millot, Camille Locht & Françoise Jacob-Dubuisson
Pages: 2608-2632
Published online: 30 Sep 2021
AbstractforPathogenicity and virulence of Bordetella pertussis and its adaptation to its strictly human host | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome
Zhao-Yi Wu, Anaamika Campeau, Chao-Hsien Liu, David J. Gonzalez, Masaya Yamaguchi, Shigetada Kawabata, Chieh-Hsien Lu, Chian-Yu Lai, Hao-Chieh Chiu & Yung-Chi Chang
Pages: 2633-2647
Published online: 01 Oct 2021
AbstractforUnique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Set1-mediated H3K4 methylation is required for Candida albicans virulence by regulating intracellular level of reactive oxygen species
Jueun Kim, Shinae Park, Sohee Kwon, Eun-Jin Lee & Jung-Shin Lee
Pages: 2648-2658
Published online: 26 Oct 2021
AbstractforSet1-mediated H3K4 methylation is required for Candida albicans virulence by regulating intracellular level of reactive oxygen species | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Sequence variations in the ETEC CS6 operon affect transcript and protein expression
Jonathan Moon & Eileen M. Barry
Pages: 2659-2669
Published online: 21 Oct 2021
AbstractforSequence variations in the ETEC CS6 operon affect transcript and protein expression | Full Text | References | PDF (930.6 KB) | EPUB | Supplemental
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Article
Pathogenesis and virulence of herpes simplex virus
Shuyong Zhu & Abel Viejo-Borbolla
Pages: 2670-2702
Published online: 22 Oct 2021
AbstractforPathogenesis and virulence of herpes simplex virus | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Mycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages
Jing Chen, Yi Zhou, Erpeng Zhu, Peng Yang, Mei Li, Shuangxiang Zhang, Jun Yue, Ming Wen, Kaigong Wang & Zhentao Cheng
Pages: 2703-2720
Published online: 22 Oct 2021
AbstractforMycoplasma ovipneumoniae induces caspase-8-dependent extrinsic apoptosis and p53- and ROS-dependent intrinsic apoptosis in murine alveolar macrophages | Full Text | References | PDF (5.5 MB) | EPUB
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Review Article
Insights into the molecular determinants involved in Mycobacterium tuberculosis persistence and their therapeutic implications
Hemant Joshi, Divya Kandari & Rakesh Bhatnagar
Pages: 2721-2749
Published online: 01 Nov 2021
AbstractforInsights into the molecular determinants involved in Mycobacterium tuberculosis persistence and their therapeutic implications | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Global regulator DksA modulates virulence of Acinetobacter baumannii
Nayeong Kim, Joo Hee Son, Kyeongmin Kim, Hyo Jeong Kim, Yoo Jeong Kim, Minsang Shin & Je Chul Lee
Pages: 2750-2763
Published online: 09 Nov 2021
AbstractforGlobal regulator DksA modulates virulence of Acinetobacter baumannii | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Article
Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection
Mingwang Long, Yue Pan, Junying Chen, Fan Jia, Han Wang, Daiying Li, Kai Feng, Lingmei Yan, Xiaodan Wang, Xuelei Ning, Lijuan Qiu, Juan Zhang & Qiangming Sun
Pages: 2764-2776
Published online: 08 Nov 2021
AbstractforSweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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Review Article
Understanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals
Hannah L. Murphy & Hinh Ly
Pages: 2777-2786
Published online: 10 Dec 2021
AbstractforUnderstanding the prevalence of SARS-CoV-2 (COVID-19) exposure in companion, captive, wild, and farmed animals | Full Text | References | PDF (751.6 KB) | EPUB
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Review Article
Identification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis
Thomas J. Roodsant, Boas C.L. Van Der Putten, Sara M. Tamminga, Constance Schultsz & Kees C.H. Van Der Ark
Pages: 2787-2797
Published online: 25 Nov 2021
AbstractforIdentification of Streptococcus suis putative zoonotic virulence factors: A systematic review and genomic meta-analysis | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
The leptospiral LipL21 and LipL41 proteins exhibit a broad spectrum of interactions with host cell components
Takahashi MB, Teixeira AF & Nascimento ALTO
Pages: 2798-2813
Published online: 25 Nov 2021
AbstractforThe leptospiral LipL21 and LipL41 proteins exhibit a broad spectrum of interactions with host cell components | Full Text | References | PDF (2 MB) | EPUB
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Review Article
Pathogenesis and virulence of flavivirus infections
Sophie Wilhelmina van Leur, Tiaan Heunis, Deeksha Munnur & Sumana Sanyal
Pages: 2814-2838
Published online: 22 Nov 2021
AbstractforPathogenesis and virulence of flavivirus infections | Full Text | References | PDF (3 MB) | EPUB
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Review Article
Pathogenicity and virulence of the liver flukes Fasciola hepatica and FasciolaGigantica that cause the zoonosis Fasciolosis
Richard Lalor, Krystyna Cwiklinski, Nichola Eliza Davies Calvani, Amber Dorey, Siobhán Hamon, Jesús López Corrales, John Pius Dalton & Carolina De Marco Verissimo
Pages: 2839-2867
Published online: 22 Nov 2021
AbstractforPathogenicity and virulence of the liver flukes Fasciola hepatica and FasciolaGigantica that cause the zoonosis Fasciolosis | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Hepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models
Junyu Lin, Jing Li, Peilin Xie, Yue Han, Demin Yu, Jia Chen & Xinxin Zhang
Pages: 2868-2882
Published online: 21 Nov 2021
AbstractforHepatitis B virus middle surface antigen loss promotes clinical variant persistence in mouse models | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Site-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus
Shuyan Lai, Mengqiong Xu, Yaohao Wang, Ruilin Li, Chuan Xia, Sisi Xia & Jun Chen
Pages: 2883-2901
Published online: 16 Dec 2021
AbstractforSite-specific SUMOylation of viral polymerase processivity factor: a way of localizingtoND10 subnuclear domains for restricted and self-controlled reproduction of herpesvirus | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 2003 Views
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Article
Serum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin
Jesús Arenas, Zalan Szabo, Jelle van der Wal, Coen Maas, Tahira Riaz, Tone Tønjum & Jan Tommassen
Pages: 2902-2917
Published online: 14 Dec 2021
AbstractforSerum proteases prevent bacterial biofilm formation: role of kallikrein and plasmin | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Review

Review Article
Persistent low-Level viremia in persons living with HIV undertreatment: An unresolved status
Celia Crespo-Bermejo, Eva Ramírez de Arellano, Violeta Lara-Aguilar, Daniel Valle-Millares, Mª Luisa Gómez-Lus, Ricardo Madrid, Luz Martín-Carbonero & Verónica Briz
Pages: 2919-2931
Published online: 07 Dec 2021
AbstractforPersistent low-Level viremia in persons living with HIV undertreatment: An unresolved status | Full Text | References | PDF (488.2 KB) | EPUB
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Article
Emergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin
Sarah Al-Beltagi, Leah V. Goulding, Daniel K.E. Chang, Kenneth H. Mellits, Christopher J. Hayes, Pavel Gershkovich, Christopher M. Coleman & Kin-Chow Chang
Pages: 2946-2956
Published online: 12 Dec 2021
AbstractforEmergent SARS-CoV-2 variants: comparative replication dynamics and high sensitivity to thapsigargin | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
The induced knockdown of GmCAD receptor protein encoding gene in Galleria mellonella decreased the insect susceptibility to a Photorhabdus akhurstii oral toxin
Tushar K. Dutta, Arudhimath Veeresh, Chetna Mathur, Victor Phani, Abhishek Mandal, Doddachowdappa Sagar & Suresh M. Nebapure
Pages: 2957-2971
Published online: 09 Dec 2021
AbstractforThe induced knockdown of GmCAD receptor protein encoding gene in Galleria mellonella decreased the insect susceptibility to a Photorhabdus akhurstii oral toxin | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
UvKmt6-mediated H3K27 trimethylation is required for development, pathogenicity, and stress response in Ustilaginoidea virens
Shuai Meng, Zhiquan Liu, Huanbin Shi, Zhongling Wu, Jiehua Qiu, Hui Wen, Fucheng Lin, Zeng Tao, Chaoxi Luo & Yanjun Kou
Pages: 2972-2988
Published online: 11 Dec 2021
AbstractforUvKmt6-mediated H3K27 trimethylation is required for development, pathogenicity, and stress response in Ustilaginoidea virens | Full Text | References | PDF (4.1 MB) | EPUB | Supplemental
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Pathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments
Hannah L. Murphy & Hinh Ly
Pages: 2989-3014
Published online: 21 Dec 2021
AbstractforPathogenicity and virulence mechanisms of Lassa virus and its animal modeling, diagnostic, prophylactic, and therapeutic developments | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract
Matthew J. Sullivan, Kelvin G. K. Goh, Ruby Thapa, Debasish Chattopadhyay, Deepak S. Ipe, Benjamin L. Duell, Lahiru Katupitiya, Dean Gosling, Dhruba Acharya & Glen C. Ulett
Pages: 3015-3027
Published online: 11 Dec 2021
AbstractforStreptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) elicits multiple cytokines from human cells and has a minor effect on bacterial persistence in the murine female reproductive tract | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
M. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responses
Jianjian Jiao, Nan Zheng, Wenjing Wei, Joy Fleming, Xingyun Wang, Zihui Li, Lili Zhang, Yi Liu, Zongde Zhang, Adong Shen, Li Chuanyou, Lijun Bi & Hongtai Zhang
Pages: 3032-3044
Published online: 09 Dec 2021
AbstractforM. tuberculosis CRISPR/Cas proteins are secreted virulence factors that trigger cellular immune responses | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Article
sRNA23, a novel small RNA, regulates to the pathogenesis of Streptococcus suis serotype 2
Quanming Xu, Hong Chen, Wen Sun, Yongyi Zhang, Dewen Zhu, Kul Raj Rai, Ji-Long Chen & Ye Chen
Pages: 3045-3061
Published online: 09 Dec 2021
AbstractforsRNA23, a novel small RNA, regulates to the pathogenesis of Streptococcus suis serotype 2 | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
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Article
Paeoniflorin reduce luxS/AI-2 system-controlled biofilm formation and virulence in Streptococcus suis
Jinpeng Li, Qingying Fan, Manyu Jin, Chenlong Mao, Hui Zhang, Xiaoling Zhang, Liyun Sun, Daniel Grenier, Li Yi, Xiaogai Hou & Yang Wang
Pages: 3062-3073
Published online: 18 Dec 2021
AbstractforPaeoniflorin reduce luxS/AI-2 system-controlled biofilm formation and virulence in Streptococcus suis | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Article
The aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic Escherichia coli (UPEC/EAEC) isolated from a urinary tract infection
Paulo A. Schüroff, Fábia A. Salvador, Cecilia M. Abe, Haleluya T. Wami, Eneas Carvalho, Rodrigo T. Hernandes, Ulrich Dobrindt, Tânia A. T. Gomes & Waldir P. Elias
Pages: 3073-3093
Published online: 20 Dec 2021
AbstractforThe aggregate-forming pili (AFP) mediates the aggregative adherence of a hybrid-pathogenic Escherichia coli (UPEC/EAEC) isolated from a urinary tract infection | Full Text | References | PDF (5.1 MB) | EPUB | Supplemental
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Article
The pathogenicity and virulence of Toxoplasma gondii
Syrian G. Sanchez & Sébastien Besteiro
Pages: 3095-3114
Published online: 11 Dec 2021
AbstractforThe pathogenicity and virulence of Toxoplasma gondii | Full Text | References | PDF (2.2 MB) | EPUB
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